Mutation associated with an autosomal dominant cone-rod dystrophy CORD7 modifies RIM1-mediated modulation of voltage-dependent Ca2+ channels. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Channels (Austin) Year : 2007

Mutation associated with an autosomal dominant cone-rod dystrophy CORD7 modifies RIM1-mediated modulation of voltage-dependent Ca2+ channels.

Abstract

Genetic analyses have revealed an association between the gene encoding the Rab3A-interacting molecule (RIM1) and the autosomal dominant cone-rod dystrophy CORD7. However, the pathogenesis of CORD7 remains unclear. We recently revealed that RIM1 regulates voltage-dependent Ca(2+) channel (VDCC) currents and anchors neurotransmitter-containing vesicles to VDCCs, thereby controlling neurotransmitter release. We demonstrate here that the mouse RIM1 arginine-to-histidine substitution (R655H), which corresponds to the human CORD7 mutation, modifies RIM1 function in regulating VDCC currents elicited by the P/Q-type Ca(v)2.1 and L-type Ca(v)1.4 channels. Thus, our data can raise an interesting possibility that CORD7 phenotypes including retinal deficits and enhanced cognition are at least partly due to altered regulation of presynaptic VDCC currents.
Fichier principal
Vignette du fichier
CORD7_Miki070626_fig.pdf (126.84 Ko) Télécharger le fichier
CORD7_Miki070626.pdf (80.34 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Origin : Files produced by the author(s)

Dates and versions

inserm-00378035 , version 1 (29-04-2009)

Identifiers

Cite

Takafumi Miki, Shigeki Kiyonaka, Yoshitsugu Uriu, Michel de Waard, Minoru Wakamori, et al.. Mutation associated with an autosomal dominant cone-rod dystrophy CORD7 modifies RIM1-mediated modulation of voltage-dependent Ca2+ channels.. Channels (Austin), 2007, 1 (3), pp.144-7. ⟨inserm-00378035⟩
54 View
215 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More