Ten-year incidence and risk factors of bone fractures in a cohort of treated HIV1-infected adults.
Résumé
In the ANRS CO8 APROCO-COPILOTE cohort of patients treated with combination antiretroviral therapy since 1997-1999, the incidence density of bone fractures was 3.3 for 1000 patient-years [95% confidence interval (CI) = 2.0-4.6]. The rate was 2.9-fold (95% CI = 1.3-6.5) higher among patients with excessive alcohol consumption and 3.6-fold (95% CI = 1.6-8.1) higher in those with hepatitis C virus (HCV) coinfection. Specific monitoring of HCV/HIV-coinfected patients and active promotion of alcohol cessation should be recommended for the prevention of bone fractures.
Domaines
Santé publique et épidémiologie
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inserm-00374705_edited.pdf (153.64 Ko)
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AIDS_2009_01_08b_version_finale.pdf (83.03 Ko)
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Origine : Fichiers produits par l'(les) auteur(s)