In Silico Studies on DARC. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Infectious disorders drug targets Année : 2009

In Silico Studies on DARC.


The Duffy Antigen/Receptor for Chemokine (DARC) is a seven segment transmembrane protein. It was firstly discovered as a blood group antigen and was the first specific gene locus assigned to a specific autosome in man. It became more famous as an erythrocyte receptor for malaria parasites (Plasmodium vivax and Plasmodium knowlesi), and finally for chemokines. DARC is an unorthodox chemokine receptor as (i) it binds chemokines of both CC and CXC classes and (ii) it lacks the Asp-Arg-Tyr consensus motif in its second cytoplasmic loop hence cannot couple to G proteins and activate their signaling pathways. DARC had also been associated to cancer progression, numerous inflammatory diseases, and possibly to AIDS. In this review, we will summarize important biological data on DARC. Then we shall focus on recent development of the elaboration and analyzes of structural models of DARC. We underline the difficulty to propose pertinent structural models of transmembrane protein using comparative modeling process, and other dedicated approaches as the Protein Blocks. The chosen structural models encompass most of the biochemical data known to date. Finally, we present recent development of protein - protein docking between DARC structural models and CXCL-8 structures. We propose a hierarchal search based on separated rigid and flexible docking.
Fichier principal
Vignette du fichier
de_Brevern_Autin_Bertrand_Colin_Etchebest.pdf (1.95 Mo) Télécharger le fichier
inserm-00366309_edited.pdf (905.63 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

inserm-00366309 , version 1 (01-06-2010)


  • HAL Id : inserm-00366309 , version 1
  • PUBMED : 19519483


Alexandre de Brevern, Ludovic Autin, Yves Colin, Olivier Bertrand, Catherine Etchebest. In Silico Studies on DARC.. Infectious disorders drug targets, 2009, 9 (3), pp.289-303. ⟨inserm-00366309⟩
229 Consultations
375 Téléchargements



Gmail Facebook X LinkedIn More