Cancer incidence and mortality in France over the period 1980-2005.
Aurélien Belot
(1, 2, 3)
,
Pascale Grosclaude
(4)
,
Nadine Bossard
(2)
,
Eric Jougla
(5)
,
Ellen Benhamou
(6)
,
Patricia Delafosse
(7)
,
Anne Valérie Guizard
(8)
,
Florence Molinié
(9)
,
Arlette Danzon
(10)
,
Simona Bara
(11)
,
Anne Marie Bouvier
(12)
,
Brigitte Trétarre
(13)
,
Florence Binder-Foucard
(14)
,
Marc Colonna
(7, 15)
,
Laetitia Daubisse
(4)
,
Guy Hédelin
(16)
,
Guy Launoy
(17)
,
Nolwenn Le Stang
(18)
,
Marc Maynadié
(19)
,
Alain A. Monnereau
(20)
,
Xavier X. Troussard
(21)
,
Jean Faivre
(12)
,
Anne Collignon
(21)
,
Inès Janoray
(19)
,
Patrick Arveux
(22)
,
Antoine Buemi
(23)
,
Nicole Raverdy
(24)
,
Claire Schvartz
(25)
,
Martine Bovet
(5)
,
Laurence Chérié-Challine
(3)
,
Jaume Esteve
(1, 2)
,
L. Remontet
(1, 2)
,
M. Velten
(16)
1
Service de Biostatistiques [Lyon]
2 Biostatistiques santé [LBBE]
3 Département des maladies chroniques et traumatismes
4 Registre général des cancers du Tarn = Tarn Cancer Registry
5 CépiDc - Centre d'épidémiologie sur les causes médicales de décès
6 IGR - Institut Gustave Roussy
7 Registre des cancers de l’Isère [CHU de Grenoble]
8 Registre des cancers du Calvados
9 Registre des cancers de Loire‐Atlantique et Vendée
10 Registre des tumeurs du Doubs et du Territoire de Belfort [CHRU Besançon]
11 Registre des cancers de la Manche [CHPC - Site Louis Pasteur]
12 Registre Bourguignon des Cancers Digestifs
13 Registre des Tumeurs de l'Hérault
14 Registre des cancers du Bas-Rhin
15 INSERM U823 - Institut d'oncologie/développement Albert Bonniot de Grenoble
16 Registre des cancers du Bas-Rhin
17 Registre des Tumeurs Digestives [CHU Caen]
18 Registre multicentrique à vocation nationale des mésothéliomes pleuraux
19 Registre des hémopathies malignes de Côte d'Or
20 Registre des hémopathies malignes de la Gironde
21 Registre des hémopathies malignes de Basse-Normandie [CHU Caen]
22 Registre des Cancers du Sein et autres Cancers Gynécologiques de Côte d'Or - Breast and Gynaecologic Cancer Registry of Côte d’Or
23 Registre des Cancers du Haut-Rhin
24 Registre général des cancers de la Somme
25 Registre des cancers thyroïdiens de Champagne-Ardennes
2 Biostatistiques santé [LBBE]
3 Département des maladies chroniques et traumatismes
4 Registre général des cancers du Tarn = Tarn Cancer Registry
5 CépiDc - Centre d'épidémiologie sur les causes médicales de décès
6 IGR - Institut Gustave Roussy
7 Registre des cancers de l’Isère [CHU de Grenoble]
8 Registre des cancers du Calvados
9 Registre des cancers de Loire‐Atlantique et Vendée
10 Registre des tumeurs du Doubs et du Territoire de Belfort [CHRU Besançon]
11 Registre des cancers de la Manche [CHPC - Site Louis Pasteur]
12 Registre Bourguignon des Cancers Digestifs
13 Registre des Tumeurs de l'Hérault
14 Registre des cancers du Bas-Rhin
15 INSERM U823 - Institut d'oncologie/développement Albert Bonniot de Grenoble
16 Registre des cancers du Bas-Rhin
17 Registre des Tumeurs Digestives [CHU Caen]
18 Registre multicentrique à vocation nationale des mésothéliomes pleuraux
19 Registre des hémopathies malignes de Côte d'Or
20 Registre des hémopathies malignes de la Gironde
21 Registre des hémopathies malignes de Basse-Normandie [CHU Caen]
22 Registre des Cancers du Sein et autres Cancers Gynécologiques de Côte d'Or - Breast and Gynaecologic Cancer Registry of Côte d’Or
23 Registre des Cancers du Haut-Rhin
24 Registre général des cancers de la Somme
25 Registre des cancers thyroïdiens de Champagne-Ardennes
Pascale Grosclaude
- Function : Author
- PersonId : 1227901
- ORCID : 0000-0002-6755-5970
Nadine Bossard
- Function : Author
- PersonId : 169595
- IdHAL : nadine-bossard
- IdRef : 077465946
Abstract
BACKGROUND: The objective of this study was to provide updated estimates of national trends in cancer incidence and mortality for France for 1980-2005. METHODS: Twenty-five cancer sites were analysed. Incidence data over the 1975-2003 period were collected from 17 registries working at the department level, covering 16% of the French population. Mortality data for 1975-2004 were provided by the Inserm. National incidence estimates were based on the use of mortality as a correlate of incidence, mortality being available at both department and national levels. Observed incidence and mortality data were modelled using an age-cohort approach, including an interaction term. Short-term predictions from that model gave estimates of new cancer cases and cancer deaths in 2005 for France. RESULTS: The number of new cancer cases in 2005 was approximately 320,000. This corresponds to an 89% increase since 1980. Demographic changes were responsible for almost half of that increase. The remainder was largely explained by increases in prostate cancer incidence in men and breast cancer incidence in women. The relative increase in the world age-standardised incidence rate was 39%. The number of deaths from cancer increased from 130,000 to 146,000. This 13% increase was much lower than anticipated on the basis of demographic changes (37%). The relative decrease in the age-standardised mortality rate was 22%. This decrease was steeper over the 2000-2005 period in both men and women. Alcohol-related cancer incidence and mortality continued to decrease in men. The increasing trend of lung cancer incidence and mortality among women continued; this cancer was the second cause of cancer death among women. Breast cancer incidence increased regularly, whereas mortality has decreased slowly since the end of the 1990s. CONCLUSION: This study confirmed the divergence of cancer incidence and mortality trends in France over the 1980-2005 period. This divergence can be explained by the combined effects of a decrease in the incidence of the most aggressive cancers and an increase in the incidence of less aggressive cancers, partly due to changes in medical practices leading to earlier diagnoses.