Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles The Lancet Neurology Year : 2006

Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases.

Abstract

Rapid-eye-movement (REM) sleep behaviour disorder (RBD) is characterised by loss of muscular atonia and prominent motor behaviours during REM sleep. RBD can cause sleep disruption and severe injuries for the patient or bed partner. The disorder is strongly associated with neurodegenerative diseases, such as multiple-system atrophy, Parkinson's disease, dementia with Lewy bodies, and progressive supranuclear palsy. In many cases, the symptoms of RBD precede other symptoms of these neurodegenerative disorders by several years. Furthermore, several recent studies have shown that RBD is associated with abnormalities of electroencephalographic activity, cerebral blood flow, and cognitive, perceptual, and autonomic functions. RBD might be a stage in the development of neurodegenerative disorders and increased awareness of this could lead to substantial advances in knowledge of mechanisms, diagnosis, and treatment of neurodegenerative disorders.

Domains

Bioengineering

Dates and versions

inserm-00163981 , version 1 (19-07-2007)

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Cite

Jean-François Gagnon, Ronald B. Postuma, Stéphanie Mazza, Julien Doyon, Jacques Montplaisir. Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases.. The Lancet Neurology, 2006, 5 (5), pp.424-32. ⟨10.1016/S1474-4422(06)70441-0⟩. ⟨inserm-00163981⟩

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