Overexpression of cellular prion protein induces an antioxidant environment altering T cell development in the thymus. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Journal of Immunology Year : 2006

Overexpression of cellular prion protein induces an antioxidant environment altering T cell development in the thymus.

Walid Rachidi
Philippe Naquet

Abstract

Cellular prion protein (PrP(C)) is an ubiquitously expressed glycoprotein whose roles are still widely discussed, particularly in the field of immunology. Using TgA20- and Tg33-transgenic mice overexpressing PrP(C), we investigated the consequences of this overexpression on T cell development. In both models, overexpression of PrP(C) induces strong alterations at different steps of T cell maturation. On TgA20 mice, we observed that these alterations are cell autonomous and lead to a decrease of alphabeta T cells and a concomitant increase of gammadelta T cell numbers. PrP(C) has been shown to bind and chelate copper and, interestingly, under a copper supplementation diet, TgA20 mice presented a partial restoration of the alphabeta T cell development, suggesting that PrP(C) overexpression, by chelating copper, generates an antioxidant context differentially impacting on alphabeta and gammadelta T cell lineage.

Domains

Immunology
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Dates and versions

inserm-00144344 , version 1 (02-05-2007)

Identifiers

  • HAL Id : inserm-00144344 , version 1
  • PUBMED : 16517717

Cite

Evelyne Jouvin-Marche, Valérie Attuil-Audenis, Catherine Aude-Garcia, Walid Rachidi, Mark Zabel, et al.. Overexpression of cellular prion protein induces an antioxidant environment altering T cell development in the thymus.. Journal of Immunology, 2006, 176 (6), pp.3490-7. ⟨inserm-00144344⟩
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