Effects of activin-A on neurons acutely isolated from the rat supraoptic nucleus. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles J Neuroendocrinol Year : 1995

Effects of activin-A on neurons acutely isolated from the rat supraoptic nucleus.

Abstract

Nerve fibers containing activin-like immunoreactivity have been shown to be present within the area of the supraoptic nucleus. In this study, whole-cell patch-clamp recordings from supraoptic magnocellular neurosecretory cells were used to characterize the electrophysiological effects of this peptide. Nanomolar concentrations of recombinant activin-A caused the appearance of a voltage-independent current reversing near -40 mV. At resting potential, membrane depolarization caused by this current was sufficient to accelerate action potential discharge, suggesting that activin receptors expressed on magnocellular neurosecretory cells may play a role in the control of neurohypophysial hormone release.
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inserm-00000083 , version 1 (29-03-2006)

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  • HAL Id : inserm-00000083 , version 1
  • PUBMED : 8547942

Cite

Stéphane H.R. Oliet, Paul M. Plotsky, Charles W. Bourque. Effects of activin-A on neurons acutely isolated from the rat supraoptic nucleus.. J Neuroendocrinol, 1995, 7, pp.661-3. ⟨inserm-00000083⟩

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