Bacterial flagellins: mediators of pathogenicity and host immune responses in mucosa. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Trends Microbiol Year : 2004

Bacterial flagellins: mediators of pathogenicity and host immune responses in mucosa.

Abstract

Flagella contribute to the virulence of pathogenic bacteria through chemotaxis, adhesion to and invasion of host surfaces. Flagellin is the structural protein that forms the major portion of flagellar filaments. Thus, flagellin consists of a conserved domain that is widespread in bacterial species and is dedicated to filament polymerization. Conversely, mammalian hosts detect the conserved domain on flagellin monomers through Toll-like receptor (TLR) 5, which triggers proinflammatory and adaptive immune responses. This review describes the relationships among flagellin molecular structure, bacterial virulence and host defenses, with special emphasis on mucosal tissues.
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Dates and versions

inserm-00000046 , version 1 (29-03-2006)

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Hugo Cruz Ramos, Martin Rumbo, Jean-Claude Sirard. Bacterial flagellins: mediators of pathogenicity and host immune responses in mucosa.. Trends Microbiol, 2004, 12 (11), pp.509-17. ⟨10.1016/j.tim.2004.09.002⟩. ⟨inserm-00000046⟩

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