Heterogeneity of sensitization profiles and clinical phenotypes among patients with seasonal allergic rhinitis in Southern European countries—The @IT.2020 multicenter study - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Allergy Année : 2024

Heterogeneity of sensitization profiles and clinical phenotypes among patients with seasonal allergic rhinitis in Southern European countries—The @IT.2020 multicenter study

1 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
2 Università degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Université de Rome Tor Vergata [Rome, Italie]
3 Ospedale Policlinico Casilino - Policlinico Casilino
4 IRCCS Ospedale Pediatrico Bambino Gesù = Bambino Gesù Children’s Hospital
5 Ankara Yildirim Beyazit University [Turkey]
6 NKUA - National and Kapodistrian University of Athens
7 “Attikon” University Hospital
8 University of Messina
9 TIMONE - Hôpital de la Timone [CHU - APHM]
10 AMU - Aix Marseille Université
11 University of Tirana
12 University of Évora [Portugal]
13 Centro Hospitalar do Porto
14 Universidade do Porto = University of Porto
15 University of Athens Medical School [Athens]
16 General Children's Hospital of Athens P & A Kyriakou
17 Ege University [Izmir]
18 Hospital Universitari i Politècnic La Fe = University and Polytechnic Hospital La Fe
19 University of Kirikkale
20 Istanbul Arel University
21 C2VN - Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research
22 CIC - Centre d'Investigation Clinique [Hôpital de la Conception - APHM]
23 University of Manchester [Manchester]
24 Royal Manchester Children's Hospital
25 ARPA Piemonte Regional Agency for Environmental Protection
26 CUF Porto Hospital
27 Ankara Üniversitesi
28 Athens Naval Hospital
29 KUSOM - Koc University School of Medicine [Istanbul, Turkey]
30 University of Oviedo
31 RNSA - Réseau National de Surveillance Aérobiologique
32 Koç University
33 UZH - Universität Zürich [Zürich] = University of Zurich
S. Tripodi
  • Fonction : Auteur
  • PersonId : 1079241
S. Pelosi
  • Fonction : Auteur
B. Bregu
  • Fonction : Auteur
S. Caglayan Sozmen
  • Fonction : Auteur
A. Di Rienzo Businco
  • Fonction : Auteur
O. Goksel
B. Lame
  • Fonction : Auteur
G. Pajno
  • Fonction : Auteur
N. Pinar
  • Fonction : Auteur
F. Psarros
  • Fonction : Auteur
I. Sfika
  • Fonction : Auteur
J. Suarez
  • Fonction : Auteur
U. Uguz
  • Fonction : Auteur
V. Villella
  • Fonction : Auteur

Résumé

Background Pollen allergy poses a significant health and economic burden in Europe. Disease patterns are relatively homogeneous within Central and Northern European countries. However, no study broadly assessed the features of seasonal allergic rhinitis (SAR) across different Southern European countries with a standardized approach. Objective To describe sensitization profiles and clinical phenotypes of pollen allergic patients in nine Southern European cities with a uniform methodological approach. Methods Within the @IT.2020 multicenter observational study, pediatric and adult patients suffering from SAR were recruited in nine urban study centers located in seven countries. Clinical questionnaires, skin prick tests (SPT) and specific IgE (sIgE) tests with a customized multiplex assay (Euroimmun Labordiagnostika, Lübeck, Germany) were performed. Results Three hundred forty‐eight children (mean age 13.1 years, SD: 2.4 years) and 467 adults (mean age 35.7 years SD: 10.0 years) with a predominantly moderate to severe, persistent phenotype of SAR were recruited. Grass pollen major allergenic molecules (Phl p 1 and/or Phl p 5) ranged among the top three sensitizers in all study centers. Sensitization profiles were very heterogeneous, considering that patients in Rome were highly poly‐sensitized (sIgE to 3.8 major allergenic molecules per patient), while mono‐sensitization was prominent and heterogeneous in other cities, such as Marseille (sIgE to Cup a 1: n = 55/80, 68.8%) and Messina (sIgE to Par j 2: n = 47/82, 57.3%). Co‐sensitization to perennial allergens, as well as allergic comorbidities also broadly varied between study centers. Conclusions In Southern European countries, pollen allergy is heterogeneous in terms of sensitization profiles and clinical manifestations. Despite the complexity, a unique molecular, multiplex, and customized in‐vitro IgE test detected relevant sensitization in all study centers. Nevertheless, this geographical diversity in pollen allergic patients imposes localized clinical guidelines and study protocols for clinical trials of SAR in this climatically complex region.
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hal-04574624 , version 1 (14-05-2024)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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S. Dramburg, U. Grittner, E. Potapova, A. Travaglini, S. Tripodi, et al.. Heterogeneity of sensitization profiles and clinical phenotypes among patients with seasonal allergic rhinitis in Southern European countries—The @IT.2020 multicenter study. Allergy, 2024, 79 (4), pp.908-923. ⟨10.1111/all.16029⟩. ⟨hal-04574624⟩
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