Systematic and quantitative view of the antiviral arsenal of prokaryotes

Bacteria and archaea have developed multiple antiviral mechanisms, and genomic evidence indicates that several of these antiviral systems co-occur in the same strain. Here, we introduce DefenseFinder, a tool that automatically detects known antiviral systems in prokaryotic genomes. We use DefenseFinder to analyse 21000 fully sequenced prokaryotic genomes, and find that antiviral strategies vary drastically between phyla, species and strains. Variations in composition of antiviral systems correlate with genome size, viral threat, and lifestyle traits. DefenseFinder will facilitate large-scale genomic analysis of antiviral defense systems and the study of host-virus interactions in prokaryotes.

Domaines

Microbiologie et Parasitologie Génomique, Transcriptomique et Protéomique [q-bio.GN]

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s41467-022-30269.pdf (1010.22 Ko)

Origine	Publication financée par une institution

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https://hal.science/hal-03823827

Soumis le : vendredi 21 octobre 2022-11:32:21

Dernière modification le : mercredi 17 avril 2024-03:33:22

Dates et versions

hal-03823827 , version 1 (18-10-2021)

hal-03823827 , version 2 (21-10-2022)

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Paternité

Identifiants

HAL Id : hal-03823827 , version 2
DOI : 10.1038/s41467-022-30269-9
PUBMED : 35538097
PUBMEDCENTRAL : PMC9090908

Citer

Florian Tesson, Alexandre Hervé, Ernest Mordret, Marie Touchon, Camille D’humières, et al.. Systematic and quantitative view of the antiviral arsenal of prokaryotes. Nature Communications, 2022, 13 (1), pp.2561. ⟨10.1038/s41467-022-30269-9⟩. ⟨hal-03823827v2⟩

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