Lack of quadruple and quintuple mutant alleles associated with sulfadoxine-pyrimethamine resistance in Plasmodium vivax isolates from Brazilian endemic areas - Inserm - Institut national de la santé et de la recherche médicale
Article Dans Une Revue Memórias do Instituto Oswaldo Cruz Année : 2019

Lack of quadruple and quintuple mutant alleles associated with sulfadoxine-pyrimethamine resistance in Plasmodium vivax isolates from Brazilian endemic areas

Résumé

Brazil is responsible for a large number of Plasmodium vivax cases in America. Given the emergence of P. vivax parasites resistant to chloroquine and the effectiveness of antifolates in vivax malaria treatment together with a correlation between mutations in P. vivax dhfr and dhps genes and SP treatment failure, the point mutations in these genes were investigated.

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Parasitologie
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Dernière modification le : mardi 15 octobre 2024-15:10:19

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hal-02558679 , version 1 (04-05-2020)

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Larissa Rodrigues Gomes, Aline Lavigne, Patrícia Brasil, Cassio Leonel Peterka, Didier Ménard, et al.. Lack of quadruple and quintuple mutant alleles associated with sulfadoxine-pyrimethamine resistance in Plasmodium vivax isolates from Brazilian endemic areas. Memórias do Instituto Oswaldo Cruz, 2019, 114, pp.e180425. ⟨10.1590/0074-02760180425⟩. ⟨hal-02558679⟩

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