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Targeting CD28, CTLA-4 and PD-L1 Costimulation Differentially Controls Immune Synapses and Function of Human Regulatory and Conventional T-Cells

Nahzli Dilek , Nicolas Poirier , Philippe Hulin , Flora Coulon , Caroline Mary , et al.
PLoS ONE, 2013, 8 (12), pp.e83139. ⟨10.1371/journal.pone.0083139⟩
Journal articles inserm-02165637v1
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IL-7 pathway controls human T cell homing to the gut and culminates in inflammatory bowel disease mucosa

Lyssia Belarif , L. Kermarec , V. Daguin , Mary C. , R. Danger , et al.
FOCIS 2017, Jun 2017, Chicago, United States
Conference poster inserm-02161048v1
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Anti-CD28 Antibody and Belatacept Exert Differential Effects on Mechanisms of Renal Allograft Rejection

Simon Ville , Nicolas Poirier , Julien Branchereau , Vianney Charpy , Sabrina Pengam , et al.
Journal of the American Society of Nephrology, 2016, 27 (12), pp.3577-3588. ⟨10.1681/ASN.2015070774⟩
Journal articles inserm-02150329v1
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SIRPγ-CD47 Interaction Positively Regulates the Activation of Human T Cells in Situation of Chronic Stimulation

Safa Dehmani , Véronique Nerrière-Daguin , Mélanie Néel , Nathan Elain-Duret , Jean-Marie Heslan , et al.
Frontiers in Immunology, 2021, 12, pp.732530. ⟨10.3389/fimmu.2021.732530⟩
Journal articles inserm-03627808v1
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Evaluation of FR104, a Treg sparing antagonist anti-CD28 monovalent Fab' antibody in kidney transplantation in non-human primates

Nicolas Poirier , Nahzli Dilek , Caroline Mary , Jeremy Hervouet , David Minault , et al.
7th European Workshop on Immune-Mediated Inflammatory Diseases, Nov 2012, Netherlands. pp.P61
Conference papers inserm-00758213v1
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Specialized Pro-Resolving Mediators Mitigate Cancer-Related Inflammation: Role of Tumor-Associated Macrophages and Therapeutic Opportunities

Margot Lavy , Vanessa Gauttier , Nicolas Poirier , Sophie C Barillé-Nion , Christophe Blanquart
Frontiers in Immunology, 2021, 12, pp.702785. ⟨10.3389/fimmu.2021.702785⟩
Journal articles inserm-03319344v1
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Selective CD28 Antagonist Blunts Memory Immune Responses and Promotes Long-Term Control of Skin Inflammation in Nonhuman Primates

Nicolas Poirier , Melanie Chevalier , Caroline Mary , Jérémy Hervouet , David Minault , et al.
Journal of Immunology, 2016, 196 (1), pp.274-283. ⟨10.4049/jimmunol.1501810⟩
Journal articles inserm-02150299v1
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Control of transplant tolerance and intragraft regulatory T cell localization by CCL5

Nahzli Dilek , Nicolas Poirier , Claire Usal , Bernard Martinet , Gilles Blancho , et al.
7th European Workshop on Immune-Mediated Inflammatory Diseases, Nov 2012, Netherlands. pp.P60
Conference papers inserm-00758212v1

Dynamic human immune and tumour cells cross-talk in PDX-humanised mice warrants checkpoint inhibitor cancer immunotherapies assessment

Nicolas Poirier , Bernard Vanhove
Gut, 2018, pp.gutjnl--2018--316467. ⟨10.1136/gutjnl-2018-316467⟩
Journal articles hal-01881119v1
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Antagonist Anti-CD28 Therapeutics for the Treatment of Autoimmune Disorders

Bernard Vanhove , Nicolas Poirier , Fadi Fakhouri , Laetitia Laurent , Bert T Hart , et al.
Antibodies, 2017, 6, pp.19. ⟨10.3390/antib6040019⟩
Journal articles inserm-01885571v1
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First-in-Human Study in Healthy Subjects with FR104, a Pegylated Monoclonal Antibody Fragment Antagonist of CD28

Nicolas Poirier , Gilles Blancho , Maryvonne Hiance , Caroline Mary , Tim Van Assche , et al.
Journal of Immunology, 2016, 197 (12), pp.4593-4602. ⟨10.4049/jimmunol.1601538⟩
Journal articles inserm-02150993v1
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Selective Costimulation Blockade With Antagonist Anti-CD28 Therapeutics in Transplantation

Bernard Vanhove , Nicolas Poirier , Jean-Paul Soulillou , Gilles Blancho
Transplantation, 2019, Epub ahead of print. ⟨10.1097/TP.0000000000002740⟩
Journal articles inserm-02145956v1
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IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates

Lyssia Belarif , Caroline Mary , Lola Jacquemont , Hoa Le Mai , Richard Danger , et al.
Nature Communications, 2018, 9 (1), ⟨10.1038/s41467-018-06804-y⟩
Journal articles inserm-02023397v1
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IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease

Lyssia Belarif , Richard Danger , Laetitia Kermarrec , Véronique Nerrière-Daguin , Sabrina Pengam , et al.
Journal of Clinical Investigation, 2019, 129 (5), pp.1910-1925. ⟨10.1172/JCI121668⟩
Journal articles inserm-02145888v1
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Inhibition of cystathionine-γ-lyase controls interleukin-12 production by dendritic cells, delayed-type hypersensitivity and transplant rejection

Romain Vuillefroy de Silly , Flora Coulon , Nicolas Poirier , Vojislav Jovanovic , Sophie Brouard , et al.
7th European Workshop on Immune-Mediated Inflammatory Diseases, Nov 2012, Netherlands. pp.P62
Conference papers inserm-00758216v1
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Gene transfer of human CD40Ig does not prevent rejection in a non-human primate kidney allotransplantation model

Mathieu Angin , Nicolas Poirier , Nahzli Dilek , Caroline Le Guiner , Alice Toromanoff , et al.
Transplant Immunology, 2012, 27, pp.139-145
Journal articles hal-02644507v1
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CD28 blockade controls T cell activation to prevent graft-versus-host disease in primates

Benjamin K. Watkins , Victor Tkachev , Scott N. Furlan , Daniel J. Hunt , Kayla Betz , et al.
Journal of Clinical Investigation, 2018, 128 (9), pp.3991-4007. ⟨10.1172/JCI98793⟩
Journal articles inserm-02157599v1
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Comparative Analysis of piggyBac, CRISPR/Cas9 and TALEN Mediated BAC Transgenesis in the Zygote for the Generation of Humanized SIRPA Rats

Chris J Jung , Séverine Ménoret , Lucas Brusselle , Laurent Tesson , Claire Usal , et al.
Scientific Reports, 2016, 6 (1), pp.31455. ⟨10.1038/srep31455⟩
Journal articles inserm-02150699v1
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Prevention of lupus nephritis development in NZB/NZW mice by selective blockade of CD28

Laetitia Laurent , Awena Le Fur , Rozenn Le Bloas , Mélanie Néel , Caroline Mary , et al.
European Journal of Immunology, 2017, 47 (8), pp.1368-1376. ⟨10.1002/eji.201746923⟩
Journal articles inserm-02155317v1
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SIRPα blockade reinvigorates myeloid cells in the tumor microenvironment and reverses T-cell exclusion

Vanessa Gauttier , Justine Durand , Sabrina Pengam , Kevin Biteau , Mélanie Neel , et al.
AACR (American Association of Cancer Research), Mar 2019, Atlanta, United States
Conference poster inserm-02159790v1
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Co-Stimulatory Blockade of the CD28/CD80-86/CTLA-4 Balance in Transplantation: Impact on Memory T Cells?

Simon Ville , Nicolas Poirier , Gilles Blancho , Bernard Vanhove
Frontiers in Immunology, 2015, 6, ⟨10.3389/fimmu.2015.00411⟩
Journal articles inserm-02148498v1
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A quick and robust MHC typing method for free-ranging and captive primate species

N de Groot , K Stanbury , A J M de Vos-Rouweler , N. G. de Groot , Nicolas Poirier , et al.
Immunogenetics, 2017
Journal articles inserm-02156067v1
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Selective CD28 antagonist prevents Aldara-induced skin inflammation in non-human primates

Nicolas Poirier , Mélanie Chevalier , Caroline Mary , Jérémy Hervouet , David Minault , et al.
Experimental Dermatology, 2016, 25 (3), pp.233-234. ⟨10.1111/exd.12891⟩
Journal articles inserm-02150253v1
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The SIRP gene family : widespread conservation in animals, haplotypic polymorphisms in humans and its therapeutic consequences for monoclonal antibody reactivity

Rémi Guimon , Fabienne Haspot , Nicolas Poirier , Gilles Blancho , Sophie Limou , et al.
JOBIM, Jul 2019, Nantes, France
Conference poster inserm-02161736v1
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Selective Blockade of CD28-Mediated T Cell Costimulation Protects Rhesus Monkeys against Acute Fatal Experimental Autoimmune Encephalomyelitis

Krista G Haanstra , Karin Dijkman , Noun Bashir , Jan Bauer , Caroline Mary , et al.
Journal of Immunology, 2015, 194 (4), pp.1454-1466. ⟨10.4049/jimmunol.1402563⟩
Journal articles inserm-02148517v1
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Graft versus host disease in humanized mice is differentially controlled by CD28 and CD80/86 antagonists

Nicolas Poirier , Nahzli Dilek , Caroline Mary , Bernard Vanhove
7th European Workshop on Immune-Mediated Inflammatory Diseases, Nov 2012, Netherlands. pp.O2
Conference papers inserm-00758217v1
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Differential regulation of motility and immune synapses by CD28/ CTLA-4 costimulation in effector and regulatory T cells

Nahzli Dilek , Nicolas Poirier , Philippe Hulin , Gilles Blancho , Bernard Vanhove
7th European Workshop on Immune-Mediated Inflammatory Diseases, Nov 2012, Netherlands. pp.P6
Conference papers inserm-00758215v1
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Triggering the resolution of inflammation with agonistic anti-ChemR23 antibody dampens inflammation-driven carcinogenesis and metastasis

Vanessa Gauttier , Margot Lavy , Charlène Trilleaud , Kévin Biteau , Stéphanie Neyton , et al.
American Association for Cancer Researc 2021, 2021, Virtual Meeting, United States
Conference poster inserm-03349406v1
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Interleukin‐7/Interferon axis drives T‐cell and salivary gland epithelial cell interactions in Sjögren’s syndrome

Elodie Rivière , Juliette Pascaud , Alexandre Virone , Anastasia Dupré , Bineta Ly , et al.
Arthritis & rheumatology, 2020, 73 (4), pp.631-640. ⟨10.1002/art.41558⟩
Journal articles pasteur-03036519v1