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Targeting NF-kappaB pathway with an IKK2 inhibitor induces inhibition of multiple myeloma cell growth.
Michel Jourdan
,
Jérôme Moreaux
,
John De Vos
,
Dirk Hose
,
Karène Mahtouk
,
et al.
Journal articles
inserm-00160647v1
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The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor.
Anne Catherine Sprynski
,
Dirk Hose
,
Laurent Caillot
,
Thierry Rème
,
John D. Shaughnessy Jr
,
et al.
Journal articles
inserm-00367812v1
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Heparan sulphate proteoglycans are essential for the myeloma cell growth activity of EGF-family ligands in multiple myeloma.
Karène Mahtouk
,
Friedrich W. Cremer
,
Thierry Rème
,
Michel Jourdan
,
Marion Baudard
,
et al.
Journal articles
inserm-00128880v1
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Tumor necrosis factor is a survival and proliferation factor for human myeloma cells.
Michel Jourdan
,
Karin Tarte
,
Eric Legouffe
,
Jean Brochier
,
Jean-François Rossi
,
et al.
European Cytokine Network, 1999, 10 (1), pp.65-70
Journal articles
inserm-00142273v1
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Delineation of the roles of paracrine and autocrine interleukin-6 (IL-6) in myeloma cell lines in survival versus cell cycle. A possible model for the cooperation of myeloma cell growth factors.
Michel Jourdan
,
Karène Mahtouk
,
Jean-Luc Veyrune
,
Guilhem Couderc
,
Geneviève Fiol
,
et al.
European Cytokine Network, 2005, 16 (1), pp.57-64
Journal articles
inserm-00130868v1
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Heparanase influences expression and shedding of syndecan-1, and its expression by the bone marrow environment is a bad prognostic factor in multiple myeloma.
Karène Mahtouk
,
Dirk Hose
,
Pierre Raynaud
,
Michael Hundemer
,
Michel Jourdan
,
et al.
Journal articles
inserm-00136105v1
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Growth factors in multiple myeloma: a comprehensive analysis of their expression in tumor cells and bone marrow environment using Affymetrix microarrays.
Karène Mahtouk
,
Jérôme Moreaux
,
Dirk Hose
,
Thierry Rème
,
Tobias Meissner
,
et al.
Journal articles
inserm-00668220v1
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Interleukin-6 as a Therapeutic Target
Jean-François Rossi
,
Zhao-Yang Lu
,
Michel Jourdan
,
Bernard Klein
Journal articles
hal-02137928v1
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Gene expression of anti- and pro-apoptotic proteins in malignant and normal plasma cells.
Michel Jourdan
,
Thierry Rème
,
Harmut Goldschmidt
,
Geneviève Fiol
,
Véronique Pantesco
,
et al.
Journal articles
inserm-00358309v1
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The Bcl-2 family member Bfl-1/A1 is strongly repressed in normal and malignant plasma cells but is a potent anti-apoptotic factor for myeloma cells.
Karin Tarte
,
Michel Jourdan
,
Jean-Luc Veyrune
,
Ingolf Berberich
,
Geneviève Fiol
,
et al.
Journal articles
inserm-00368387v1
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Microarray-based understanding of normal and malignant plasma cells.
John de Vos
,
Dirk Hose
,
Thierry Rème
,
Karin Tarte
,
Jérôme Moreaux
,
et al.
Journal articles
inserm-00149827v1
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An in vitro model of differentiation of memory B cells into plasmablasts and plasma cells including detailed phenotypic and molecular characterization.
Michel Jourdan
,
Anouk Caraux
,
John de Vos
,
Geneviève Fiol
,
Marion Larroque
,
et al.
Journal articles
inserm-00446133v1
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Expression of EGF-family receptors and amphiregulin in multiple myeloma. Amphiregulin is a growth factor for myeloma cells.
Karène Mahtouk
,
Dirk Hose
,
Thierry Rème
,
John de Vos
,
Michel Jourdan
,
et al.
Journal articles
inserm-00130206v1
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An inhibitor of the EGF receptor family blocks myeloma cell growth factor activity of HB-EGF and potentiates dexamethasone or anti-IL-6 antibody-induced apoptosis.
Karène Mahtouk
,
Michel Jourdan
,
John de Vos
,
Catherine Hertogh
,
Geneviève Fiol
,
et al.
Journal articles
inserm-00130207v1
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Survival and proliferation factors of normal and malignant plasma cells.
Bernard Klein
,
Karin Tarte
,
Michel Jourdan
,
Karene Mathouk
,
Jérôme Moreaux
,
et al.
International Journal of Hematology, 2003, 78 (2), pp.106-13
Journal articles
inserm-00130900v1
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APRIL and TACI interact with syndecan-1 on the surface of multiple myeloma cells to form an essential survival loop.
Jérôme Moreaux
,
Anne-Catherine Sprynski
,
Stacey R. Dillon
,
Karène Mahtouk
,
Michel Jourdan
,
et al.
Journal articles
inserm-00397249v1
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Input of DNA microarrays to identify novel mechanisms in multiple myeloma biology and therapeutic applications.
Karène Mahtouk
,
Dirk Hose
,
John de Vos
,
Jérôme Moreaux
,
Michel Jourdan
,
et al.
Journal articles
inserm-00270566v1
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A major role for Mcl-1 antiapoptotic protein in the IL-6-induced survival of human myeloma cells.
Michel Jourdan
,
Jean-Luc Veyrune
,
John De Vos
,
Nicole Redal
,
Guilhem Couderc
,
et al.
Journal articles
inserm-00130855v1
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A high-risk signature for patients with multiple myeloma established from the molecular classification of human myeloma cell lines.
Jérôme Moreaux
,
Bernard Klein
,
Régis Bataille
,
Géraldine Descamps
,
Sophie Maïga
,
et al.
Journal articles
inserm-00550232v1
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TACI expression is associated with a mature bone marrow plasma cell signature and C-MAF overexpression in human myeloma cell lines.
Jérôme Moreaux
,
Dirk Hose
,
Michel Jourdan
,
Thierry Rème
,
Michael Hundemer
,
et al.
Haematologica, 2007, 92 (6), pp.803-11
Journal articles
inserm-00162002v1
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GenomicScape: An Easy-to-Use Web Tool for Gene Expression Data Analysis. Application to Investigate the Molecular Events in the Differentiation of B Cells into Plasma Cells
Alboukadel Kassambara
,
Thierry Rème
,
Michel Jourdan
,
Thierry Fest
,
Dirk Hose
,
et al.
Journal articles
hal-01112225v1
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Insulin is a potent myeloma cell growth factor through insulin/IGF-1 hybrid receptor activation.
Anne Catherine Sprynski
,
Dirk Hose
,
Alboukadel Kassambara
,
Laure Vincent
,
Michel Jourdan
,
et al.
Journal articles
inserm-00528166v1
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Regulation of Bcl-2-family proteins in myeloma cells by three myeloma survival factors: interleukin-6, interferon-alpha and insulin-like growth factor 1.
Michel Jourdan
,
John de Vos
,
Nadir Mechti
,
Bernard Klein
Journal articles
inserm-00130981v1
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Characterization of human FCRL4-positive B cells
Michel Jourdan
,
Nicolas Robert
,
Maïlys Cren
,
Coraline Thibaut
,
Christophe Duperray
,
et al.
Journal articles
hal-01560458v1
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