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authFullName_s : Gaël Ménasché
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A RAB27A duplication in several cases of Griscelli syndrome type 2: An explanation for cases lacking a genetic diagnosis

Virginie Grandin , Fernando Sepulveda , Nathalie Lambert , Mofareh Al Zahrani , Eman Al Idrissi , et al.
Human Mutation, 2017, 38 (10), pp.1355-1359. ⟨10.1002/humu.23274⟩
Journal articles inserm-02440257v1

Polygenic mutations in the cytotoxicity pathway increase susceptibility to develop HLH immunopathology in mice

Fernando Sepulveda , Alexandrine Garrigue , Sophia Maschalidi , Meriem Garfa-Traore , Gaël Ménasché , et al.
Blood, 2016, 127 (17), pp.2113-2121. ⟨10.1182/blood-2015-12-688960⟩
Journal articles inserm-02440270v1
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Inherited defects in lymphocyte cytotoxic activity

Jana Pachlopnik Schmid , Marjorie Côte , Mickaël Ménager , Agathe Burgess , Nadine Nehme , et al.
Immunological Reviews, 2010, 235 (1), pp.10-23. ⟨10.1111/j.0105-2896.2010.00890.x⟩
Journal articles istex inserm-02440308v1

EBAG9 tempers lymphocyte killing activity

Gaël Ménasché , Geneviève de Saint Basile
Journal of Clinical Investigation, 2009, 119 (8), pp.2136-40. ⟨10.1172/JCI40270⟩
Journal articles inserm-02440322v1
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Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4

Mickaël Ménager , Gaël Ménasché , Maryse Romao , Perrine Knapnougel , Chen-Hsuan Ho , et al.
Nature Immunology, 2007, 8 (3), pp.257-267. ⟨10.1038/ni1431⟩
Journal articles istex inserm-02440339v1
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HDAC6 regulates the dynamics of lytic granules in cytotoxic T lymphocytes

Norman Núñez-Andrade , Salvador Iborra , Antonio Trullo , Olga Moreno-Gonzalo , Enrique Calvo , et al.
Journal of Cell Science, 2016, 129 (7), pp.1305-1311. ⟨10.1242/jcs.180885⟩
Journal articles inserm-02440265v1
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Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A F-exon deletion (GS1)

Gaël Ménasché , Chen Hsuan Ho , Ozden Sanal , Jerome Feldmann , Ilhan Tezcan , et al.
Journal of Clinical Investigation, 2003, 112 (3), pp.450-456. ⟨10.1172/JCI18264⟩
Journal articles inserm-02440362v1
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LYST Controls the Biogenesis of the Endosomal Compartment Required for Secretory Lysosome Function

Fernando Sepulveda , Agathe Burgess , Xavier Heiligenstein , Nicolas Goudin , Mickaël Ménager , et al.
Traffic, 2015, 16 (2), pp.191-203. ⟨10.1111/tra.12244⟩
Journal articles inserm-02440278v1
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Rab27A and its effector MyRIP link secretory granules to F-actin and control their motion towards release sites

Claire Desnos , Jean-Sébastien Schonn , Sébastien Huet , Viet Samuel Tran , Aziz El-Amraoui , et al.
Journal of Cell Biology, 2003, 163 (3), pp.559. ⟨10.1083/jcb.200302157⟩
Journal articles hal-01274137v1

Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells

Marjorie Côte , Mickaël Ménager , Agathe Burgess , Nizar Mahlaoui , Capucine Picard , et al.
Journal of Clinical Investigation, 2009, 119 (12), pp.3765-3773. ⟨10.1172/JCI40732⟩
Journal articles inserm-02440316v1
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Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome

Gaël Ménasché , Elodie Pastural , Jerome Feldmann , Stéphanie Certain , Fügen Ersoy , et al.
Nature Genetics, 2000, 25 (2), pp.173-176. ⟨10.1038/76024⟩
Journal articles inserm-02440377v1

The ADAP/SKAP55 Signaling Module Regulates T-Cell Receptor-Mediated Integrin Activation through Plasma Membrane Targeting of Rap1

Stefanie Kliche , Dennis Breitling , Mauro Togni , Rico Pusch , Katja Heuer , et al.
Molecular and Cellular Biology, 2006, 26 (19), pp.7130-7144. ⟨10.1128/MCB.00331-06⟩
Journal articles inserm-02440345v1

Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11

Fernando Sepulveda , Franck Debeurme , Gaël Ménasché , Mathieu Kurowska , Marjorie Côte , et al.
Blood, 2013, 121 (4), pp.595-603. ⟨10.1182/blood-2012-07-440339⟩
Journal articles inserm-02440279v1
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A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion

Gaël Ménasché , Mickaël Ménager , Juliette Lefebvre , Einat Deutsch , Rafika Athman , et al.
Blood, 2008, 112 (13), pp.5052-5062. ⟨10.1182/blood-2008-02-141069⟩
Journal articles inserm-02440327v1

Kinesin-1 Is a New Actor Involved in Platelet Secretion and Thrombus Stability

Frédéric Adam , Alexandre Kauskot , Mathieu Kurowska , Nicolas Goudin , Isabelle Munoz , et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 2018, 38 (5), pp.1037-1051. ⟨10.1161/ATVBAHA.117.310373⟩
Journal articles inserm-02440288v1
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Kinesin-1 regulates antigen cross-presentation through the scission of tubulations from early endosomes in dendritic cells

Meriem Belabed , François-Xavier Mauvais , Sophia Maschalidi , Mathieu Kurowska , Nicolas Goudin , et al.
Nature Communications, 2020, 11 (1), pp.1817. ⟨10.1038/s41467-020-15692-0⟩
Journal articles inserm-02641196v1

Regulation of T-cell antigen receptor-mediated inside-out signaling by cytosolic adapter proteins and Rap1 effector molecules

Gaël Ménasché , Stefanie Kliche , Natalie Bezman , Burkhart Schraven
Immunological Reviews, 2007, 218 (1), pp.82-91. ⟨10.1111/j.1600-065X.2007.00543.x⟩
Journal articles istex inserm-02440332v1

Severe and progressive encephalitis as a presenting manifestation of a novel missense perforin mutation and impaired cytolytic activity

Jerome Feldmann , Gaël Ménasché , Isabelle Callebaut , Veronique Minard-Colin , Brigitte Bader-Meunier , et al.
Blood, 2005, 105 (7), pp.2658-2663. ⟨10.1182/blood-2004-09-3590⟩
Journal articles inserm-02440351v1

Biochemical and functional characterization of Rab27a mutations occurring in Griscelli syndrome patients

Gaël Ménasché , Jerome Feldmann , Anne Houdusse , Catherine Desaymard , Alain Fischer , et al.
Blood, 2003, 101 (7), pp.2736-2742. ⟨10.1182/blood-2002-09-2789⟩
Journal articles inserm-02440369v1
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Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules

Geneviève de Saint Basile , Gaël Ménasché , Alain Fischer
Nature Reviews Immunology, 2010, 10 (8), pp.568-579. ⟨10.1038/nri2803⟩
Journal articles istex inserm-02440303v1
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RIAM Links the ADAP/SKAP-55 Signaling Module to Rap1, Facilitating T-Cell-Receptor-Mediated Integrin Activation

Gaël Ménasché , Stefanie Kliche , Emily Chen , Theresia Stradal , Burkhart Schraven , et al.
Molecular and Cellular Biology, 2007, 27 (11), pp.4070-4081. ⟨10.1128/MCB.02011-06⟩
Journal articles inserm-02440336v1
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Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-dependent recruitment to the granular Slp3/Rab27b complex

Isabelle Munoz , Luca Danelli , Julien Claver , Nicolas Goudin , Mathieu Kurowska , et al.
Journal of Cell Biology, 2016, 215 (2), pp.203-216. ⟨10.1083/jcb.201605073⟩
Journal articles inserm-01415529v1
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Insulin-regulated aminopeptidase contributes to setting the intensity of FcR-mediated inflammation

Manuela Bratti , Shamila Vibhushan , Cyril Longé , Despoina Koumantou , Gaël Ménasché , et al.
Frontiers in Immunology, 2022, 13, pp.1029759. ⟨10.3389/fimmu.2022.1029759⟩
Journal articles inserm-03998813v1
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Tomosyn functions as a PKCδ-regulated fusion clamp in mast cell degranulation

Iris Madera-Salcedo , Luca Danelli , Neeraj Tiwari , Barbara Dema , Emeline Pacreau , et al.
Science Signaling, 2018, 11 (537), pp.eaan4350. ⟨10.1126/scisignal.aan4350⟩
Journal articles inserm-02323254v1
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Inherited defects causing hemophagocytic lymphohistiocytic syndrome

Geneviève de Saint Basile , Gaël Ménasché , Sylvain Latour
Annals of the New York Academy of Sciences, 2011, 1246 (1), pp.64-76. ⟨10.1111/j.1749-6632.2011.06307.x⟩
Journal articles istex inserm-02440299v1