<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of inserm-05442623</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-18T19:39:06+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Next-Generation Multicenter Studies: Using Artificial Intelligence to Automatically Process Unstructured Health Records of Patients with Lung Cancer across Multiple Institutions</title>
            <author role="aut">
              <persName>
                <forename type="first">Mihaela</forename>
                <surname>Aldea</surname>
              </persName>
              <email type="md5">064e0a03ace6beb5ddf2e1e2e1dab39c</email>
              <email type="domain">gustaveroussy.fr</email>
              <idno type="idhal" notation="numeric">1274226</idno>
              <idno type="halauthorid" notation="string">2352582-1274226</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7685-051X</idno>
              <affiliation ref="#struct-1051146"/>
              <affiliation ref="#struct-531263"/>
              <affiliation ref="#struct-28519"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">L.</forename>
                <surname>Zullo</surname>
              </persName>
              <idno type="idhal" notation="numeric">1629149</idno>
              <idno type="halauthorid" notation="string">1195067-1629149</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1659-788X</idno>
              <affiliation ref="#struct-1051146"/>
              <affiliation ref="#struct-531263"/>
              <affiliation ref="#struct-28519"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">V.</forename>
                <surname>Levrat</surname>
              </persName>
              <idno type="halauthorid">2170551-0</idno>
              <affiliation ref="#struct-1077089"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">J.</forename>
                <surname>Bennouna</surname>
              </persName>
              <idno type="halauthorid">562687-0</idno>
              <affiliation ref="#struct-1085260"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">S.</forename>
                <surname>Schneider</surname>
              </persName>
              <idno type="halauthorid">191569-0</idno>
              <affiliation ref="#struct-347702"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">O.</forename>
                <surname>Mercier</surname>
              </persName>
              <email type="md5">1f14879cf31474ef003a0ae5550980f8</email>
              <email type="domain">ghpsj.fr</email>
              <idno type="idhal" notation="string">olaf-mercier</idno>
              <idno type="idhal" notation="numeric">739087</idno>
              <idno type="halauthorid" notation="string">263297-739087</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4760-6267</idno>
              <idno type="IDREF">https://www.idref.fr/076094820</idno>
              <affiliation ref="#struct-1041767"/>
              <affiliation ref="#struct-419361"/>
              <affiliation ref="#struct-322615"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">E.</forename>
                <surname>Mougenot</surname>
              </persName>
              <idno type="halauthorid">3972756-0</idno>
              <affiliation ref="#struct-499039"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">E.</forename>
                <surname>Bergot</surname>
              </persName>
              <idno type="halauthorid">1108170-0</idno>
              <affiliation ref="#struct-300185"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">C.</forename>
                <surname>Dujon</surname>
              </persName>
              <idno type="halauthorid">3972757-0</idno>
              <affiliation ref="#struct-302301"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">N.</forename>
                <surname>Cloarec</surname>
              </persName>
              <idno type="idhal" notation="numeric">1431865</idno>
              <idno type="halauthorid" notation="string">1326912-1431865</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9543-0729</idno>
              <affiliation ref="#struct-357527"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">C.Audigier</forename>
                <surname>Valette</surname>
              </persName>
              <idno type="halauthorid">3972758-0</idno>
              <affiliation ref="#struct-541279"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">A.</forename>
                <surname>Nuccio</surname>
              </persName>
              <idno type="idhal" notation="numeric">1629150</idno>
              <idno type="halauthorid" notation="string">3972759-1629150</idno>
              <idno type="ORCID">https://orcid.org/0009-0005-3571-7006</idno>
              <affiliation ref="#struct-1051146"/>
              <affiliation ref="#struct-531263"/>
              <affiliation ref="#struct-28519"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">M.</forename>
                <surname>Deloger</surname>
              </persName>
              <idno type="halauthorid">424271-0</idno>
              <affiliation ref="#struct-1051146"/>
              <affiliation ref="#struct-531263"/>
              <affiliation ref="#struct-456658"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">C.</forename>
                <surname>Helissey</surname>
              </persName>
              <idno type="halauthorid">890642-0</idno>
              <affiliation ref="#struct-322588"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">S.</forename>
                <surname>Simon</surname>
              </persName>
              <idno type="halauthorid">349355-0</idno>
              <affiliation ref="#struct-1051146"/>
              <affiliation ref="#struct-531263"/>
              <affiliation ref="#struct-456658"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">A.</forename>
                <surname>Carpentier</surname>
              </persName>
              <idno type="halauthorid">52622-0</idno>
              <affiliation ref="#struct-353778"/>
              <affiliation ref="#struct-413221"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">A.</forename>
                <surname>Djarallah</surname>
              </persName>
              <idno type="halauthorid">3972760-0</idno>
              <affiliation ref="#struct-1764632"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">P.</forename>
                <surname>Rolland</surname>
              </persName>
              <idno type="halauthorid">188736-0</idno>
              <affiliation ref="#struct-357472"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">J.C.</forename>
                <surname>Louis</surname>
              </persName>
              <idno type="halauthorid">3972761-0</idno>
              <affiliation ref="#struct-1764632"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">L.</forename>
                <surname>Ancillon</surname>
              </persName>
              <idno type="halauthorid">2198077-0</idno>
              <affiliation ref="#struct-1764632"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">B.</forename>
                <surname>Vignal</surname>
              </persName>
              <idno type="halauthorid">3972762-0</idno>
              <affiliation ref="#struct-1764632"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">F.</forename>
                <surname>Rambaud</surname>
              </persName>
              <idno type="halauthorid">412030-0</idno>
              <affiliation ref="#struct-1764632"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">P.</forename>
                <surname>Tessier</surname>
              </persName>
              <idno type="halauthorid">780375-0</idno>
              <affiliation ref="#struct-1764632"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">L.</forename>
                <surname>Chuttoo</surname>
              </persName>
              <idno type="halauthorid">3972763-0</idno>
              <affiliation ref="#struct-1764632"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">K.</forename>
                <surname>Siby</surname>
              </persName>
              <idno type="halauthorid">3972764-0</idno>
              <affiliation ref="#struct-1764632"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">A.</forename>
                <surname>Poplu</surname>
              </persName>
              <idno type="halauthorid">3972765-0</idno>
              <affiliation ref="#struct-1764632"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">K.</forename>
                <surname>Zarca</surname>
              </persName>
              <idno type="halauthorid">2429189-0</idno>
              <affiliation ref="#struct-1764632"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">S.</forename>
                <surname>Michiels</surname>
              </persName>
              <email type="md5">d172845fdfd48768102dd9b391930ba4</email>
              <email type="domain">gustaveroussy.fr</email>
              <idno type="idhal" notation="string">stefan-michiels</idno>
              <idno type="idhal" notation="numeric">759812</idno>
              <idno type="halauthorid" notation="string">98277-759812</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6963-2968</idno>
              <idno type="IDREF">https://www.idref.fr/129474622</idno>
              <affiliation ref="#struct-1051097"/>
              <affiliation ref="#struct-1051100"/>
              <affiliation ref="#struct-419361"/>
              <affiliation ref="#struct-59772"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">F.</forename>
                <surname>Barlesi</surname>
              </persName>
              <idno type="halauthorid">467225-0</idno>
              <affiliation ref="#struct-28519"/>
              <affiliation ref="#struct-1042019"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">F.</forename>
                <surname>Le Ouay</surname>
              </persName>
              <idno type="halauthorid">3972766-0</idno>
              <affiliation ref="#struct-1764632"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">B.</forename>
                <surname>Besse</surname>
              </persName>
              <idno type="idhal" notation="numeric">1186882</idno>
              <idno type="halauthorid" notation="string">1618761-1186882</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5090-8189</idno>
              <affiliation ref="#struct-28519"/>
              <affiliation ref="#struct-456658"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Camille</forename>
                <surname>Dumont</surname>
              </persName>
              <email type="md5">b1c4bb88abdf7b7f2e6c516887f42b5a</email>
              <email type="domain">gustaveroussy.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2026-01-05 19:50:08</date>
              <date type="whenModified">2026-04-03 10:58:01</date>
              <date type="whenReleased">2026-02-05 14:19:09</date>
              <date type="whenProduced">2025-12</date>
              <date type="whenEndEmbargoed">2026-01-05</date>
              <ref type="file" target="https://inserm.hal.science/inserm-05442623v1/document">
                <date notBefore="2026-01-05"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://inserm.hal.science/inserm-05442623v1/file/2025_Michiels_AnnOncol.pdf" id="file-5442623-4703756">
                <date notBefore="2026-01-05"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="1465599">
                <persName>
                  <forename>Camille</forename>
                  <surname>Dumont</surname>
                </persName>
                <email type="md5">b1c4bb88abdf7b7f2e6c516887f42b5a</email>
                <email type="domain">gustaveroussy.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">inserm-05442623</idno>
            <idno type="halUri">https://inserm.hal.science/inserm-05442623</idno>
            <idno type="halBibtex">aldea:inserm-05442623</idno>
            <idno type="halRefHtml">&lt;i&gt;Annals of Oncology&lt;/i&gt;, 2025, Online ahead of print. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.annonc.2025.12.006"&gt;&amp;#x27E8;10.1016/j.annonc.2025.12.006&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Annals of Oncology, 2025, Online ahead of print. &amp;#x27E8;10.1016/j.annonc.2025.12.006&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://hal.science/licences/copyright/">Copyright - All rights reserved<ref corresp="#file-5442623-4703756"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="SHS">Sciences de l'Homme et de la Société</idno>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="CEA">CEA - Commissariat à l'énergie atomique</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-ANGERS">Université d'Angers</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="CESP" corresp="INSERM">Centre de recherche en Épidémiologie et Santé des Populations</idno>
            <idno type="stamp" n="FNCLCC" corresp="INSERM">UNICANCER</idno>
            <idno type="stamp" n="IGR" corresp="FNCLCC">Institut Gustave Roussy</idno>
            <idno type="stamp" n="UVSQ">Université de Versailles Saint-Quentin-en-Yvelines</idno>
            <idno type="stamp" n="COMUE-NORMANDIE">Normandie Université</idno>
            <idno type="stamp" n="CEA-UPSAY" corresp="CEA">CEA - Université Paris-Saclay</idno>
            <idno type="stamp" n="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="JOLIOT" corresp="CEA">Institut des Sciences du Vivant Frédéric JOLIOT</idno>
            <idno type="stamp" n="CEA-DRF" corresp="CEA">Direction de Recherche Fondamentale</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="SORBONNE-UNIV" corresp="SORBONNE-UNIVERSITE">Sorbonne Université 01/01/2018</idno>
            <idno type="stamp" n="SU-MEDECINE" corresp="SORBONNE-UNIVERSITE">Faculté de Santé de Sorbonne Université</idno>
            <idno type="stamp" n="SU-MED" corresp="SORBONNE-UNIVERSITE">Médecine - Sorbonne Université</idno>
            <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
            <idno type="stamp" n="UVSQ-UPSACLAY" corresp="UNIV-PARIS-SACLAY">UVSQ-UPSACLAY</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS-SACLAY" corresp="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="SU-TI">Sorbonne Université - Texte Intégral</idno>
            <idno type="stamp" n="GS-LIFE-SCIENCES-HEALTH" corresp="UNIVERSITE-PARIS-SACLAY">Graduate School Life Sciences and Health</idno>
            <idno type="stamp" n="GS-HEALTH-DRUG-SCIENCES">Graduate School Health and Drug Sciences</idno>
            <idno type="stamp" n="GS-SANTE-PUBLIQUE">Graduate School Santé publique</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
            <idno type="stamp" n="CRCI2NA">Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers</idno>
            <idno type="stamp" n="NANTES-UNIVERSITE">Nantes Université</idno>
            <idno type="stamp" n="NANTES-UNIV">Nantes Université</idno>
            <idno type="stamp" n="ONCOSTAT">ONCOSTAT</idno>
            <idno type="stamp" n="PMNCO">Prédicteurs moléculaires et nouvelles cibles en oncologie</idno>
            <idno type="stamp" n="RESEAU-EAU">Réseau "Systèmes Agricoles et Eau"</idno>
            <idno type="stamp" n="AMMICA">Analyse moléculaire, modélisation et imagerie de la maladie cancéreuse</idno>
            <idno type="stamp" n="HPPIT">Hypertension pulmonaire : physiopathologie et innovation thérapeutique</idno>
            <idno type="stamp" n="UFR-MEDECINE-NANTES">UFR de médecine - Nantes Université</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Next-Generation Multicenter Studies: Using Artificial Intelligence to Automatically Process Unstructured Health Records of Patients with Lung Cancer across Multiple Institutions</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Mihaela</forename>
                    <surname>Aldea</surname>
                  </persName>
                  <email type="md5">064e0a03ace6beb5ddf2e1e2e1dab39c</email>
                  <email type="domain">gustaveroussy.fr</email>
                  <idno type="idhal" notation="numeric">1274226</idno>
                  <idno type="halauthorid" notation="string">2352582-1274226</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7685-051X</idno>
                  <affiliation ref="#struct-1051146"/>
                  <affiliation ref="#struct-531263"/>
                  <affiliation ref="#struct-28519"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">L.</forename>
                    <surname>Zullo</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1629149</idno>
                  <idno type="halauthorid" notation="string">1195067-1629149</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1659-788X</idno>
                  <affiliation ref="#struct-1051146"/>
                  <affiliation ref="#struct-531263"/>
                  <affiliation ref="#struct-28519"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">V.</forename>
                    <surname>Levrat</surname>
                  </persName>
                  <idno type="halauthorid">2170551-0</idno>
                  <affiliation ref="#struct-1077089"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J.</forename>
                    <surname>Bennouna</surname>
                  </persName>
                  <idno type="halauthorid">562687-0</idno>
                  <affiliation ref="#struct-1085260"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">S.</forename>
                    <surname>Schneider</surname>
                  </persName>
                  <idno type="halauthorid">191569-0</idno>
                  <affiliation ref="#struct-347702"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">O.</forename>
                    <surname>Mercier</surname>
                  </persName>
                  <email type="md5">1f14879cf31474ef003a0ae5550980f8</email>
                  <email type="domain">ghpsj.fr</email>
                  <idno type="idhal" notation="string">olaf-mercier</idno>
                  <idno type="idhal" notation="numeric">739087</idno>
                  <idno type="halauthorid" notation="string">263297-739087</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4760-6267</idno>
                  <idno type="IDREF">https://www.idref.fr/076094820</idno>
                  <affiliation ref="#struct-1041767"/>
                  <affiliation ref="#struct-419361"/>
                  <affiliation ref="#struct-322615"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">E.</forename>
                    <surname>Mougenot</surname>
                  </persName>
                  <idno type="halauthorid">3972756-0</idno>
                  <affiliation ref="#struct-499039"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">E.</forename>
                    <surname>Bergot</surname>
                  </persName>
                  <idno type="halauthorid">1108170-0</idno>
                  <affiliation ref="#struct-300185"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">C.</forename>
                    <surname>Dujon</surname>
                  </persName>
                  <idno type="halauthorid">3972757-0</idno>
                  <affiliation ref="#struct-302301"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">N.</forename>
                    <surname>Cloarec</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1431865</idno>
                  <idno type="halauthorid" notation="string">1326912-1431865</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9543-0729</idno>
                  <affiliation ref="#struct-357527"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">C.Audigier</forename>
                    <surname>Valette</surname>
                  </persName>
                  <idno type="halauthorid">3972758-0</idno>
                  <affiliation ref="#struct-541279"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">A.</forename>
                    <surname>Nuccio</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1629150</idno>
                  <idno type="halauthorid" notation="string">3972759-1629150</idno>
                  <idno type="ORCID">https://orcid.org/0009-0005-3571-7006</idno>
                  <affiliation ref="#struct-1051146"/>
                  <affiliation ref="#struct-531263"/>
                  <affiliation ref="#struct-28519"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">M.</forename>
                    <surname>Deloger</surname>
                  </persName>
                  <idno type="halauthorid">424271-0</idno>
                  <affiliation ref="#struct-1051146"/>
                  <affiliation ref="#struct-531263"/>
                  <affiliation ref="#struct-456658"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">C.</forename>
                    <surname>Helissey</surname>
                  </persName>
                  <idno type="halauthorid">890642-0</idno>
                  <affiliation ref="#struct-322588"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">S.</forename>
                    <surname>Simon</surname>
                  </persName>
                  <idno type="halauthorid">349355-0</idno>
                  <affiliation ref="#struct-1051146"/>
                  <affiliation ref="#struct-531263"/>
                  <affiliation ref="#struct-456658"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">A.</forename>
                    <surname>Carpentier</surname>
                  </persName>
                  <idno type="halauthorid">52622-0</idno>
                  <affiliation ref="#struct-353778"/>
                  <affiliation ref="#struct-413221"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">A.</forename>
                    <surname>Djarallah</surname>
                  </persName>
                  <idno type="halauthorid">3972760-0</idno>
                  <affiliation ref="#struct-1764632"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">P.</forename>
                    <surname>Rolland</surname>
                  </persName>
                  <idno type="halauthorid">188736-0</idno>
                  <affiliation ref="#struct-357472"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J.C.</forename>
                    <surname>Louis</surname>
                  </persName>
                  <idno type="halauthorid">3972761-0</idno>
                  <affiliation ref="#struct-1764632"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">L.</forename>
                    <surname>Ancillon</surname>
                  </persName>
                  <idno type="halauthorid">2198077-0</idno>
                  <affiliation ref="#struct-1764632"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">B.</forename>
                    <surname>Vignal</surname>
                  </persName>
                  <idno type="halauthorid">3972762-0</idno>
                  <affiliation ref="#struct-1764632"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">F.</forename>
                    <surname>Rambaud</surname>
                  </persName>
                  <idno type="halauthorid">412030-0</idno>
                  <affiliation ref="#struct-1764632"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">P.</forename>
                    <surname>Tessier</surname>
                  </persName>
                  <idno type="halauthorid">780375-0</idno>
                  <affiliation ref="#struct-1764632"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">L.</forename>
                    <surname>Chuttoo</surname>
                  </persName>
                  <idno type="halauthorid">3972763-0</idno>
                  <affiliation ref="#struct-1764632"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">K.</forename>
                    <surname>Siby</surname>
                  </persName>
                  <idno type="halauthorid">3972764-0</idno>
                  <affiliation ref="#struct-1764632"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">A.</forename>
                    <surname>Poplu</surname>
                  </persName>
                  <idno type="halauthorid">3972765-0</idno>
                  <affiliation ref="#struct-1764632"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">K.</forename>
                    <surname>Zarca</surname>
                  </persName>
                  <idno type="halauthorid">2429189-0</idno>
                  <affiliation ref="#struct-1764632"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">S.</forename>
                    <surname>Michiels</surname>
                  </persName>
                  <email type="md5">d172845fdfd48768102dd9b391930ba4</email>
                  <email type="domain">gustaveroussy.fr</email>
                  <idno type="idhal" notation="string">stefan-michiels</idno>
                  <idno type="idhal" notation="numeric">759812</idno>
                  <idno type="halauthorid" notation="string">98277-759812</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6963-2968</idno>
                  <idno type="IDREF">https://www.idref.fr/129474622</idno>
                  <affiliation ref="#struct-1051097"/>
                  <affiliation ref="#struct-1051100"/>
                  <affiliation ref="#struct-419361"/>
                  <affiliation ref="#struct-59772"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">F.</forename>
                    <surname>Barlesi</surname>
                  </persName>
                  <idno type="halauthorid">467225-0</idno>
                  <affiliation ref="#struct-28519"/>
                  <affiliation ref="#struct-1042019"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">F.</forename>
                    <surname>Le Ouay</surname>
                  </persName>
                  <idno type="halauthorid">3972766-0</idno>
                  <affiliation ref="#struct-1764632"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">B.</forename>
                    <surname>Besse</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1186882</idno>
                  <idno type="halauthorid" notation="string">1618761-1186882</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5090-8189</idno>
                  <affiliation ref="#struct-28519"/>
                  <affiliation ref="#struct-456658"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">10495</idno>
                <idno type="issn">0923-7534</idno>
                <idno type="eissn">1569-8041</idno>
                <title level="j">Annals of Oncology</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="pp">Online ahead of print</biblScope>
                  <date type="datePub">2025-12</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.annonc.2025.12.006</idno>
              <idno type="pubmed">41407195</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">artificial intelligence</term>
                <term xml:lang="en">large language models</term>
                <term xml:lang="en">electronic health records</term>
                <term xml:lang="en">real-world data</term>
                <term xml:lang="en">multicenter</term>
                <term xml:lang="en">consortium</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.can">Life Sciences [q-bio]/Cancer</classCode>
              <classCode scheme="halDomain" n="shs.stat">Humanities and Social Sciences/Methods and statistics</classCode>
              <classCode scheme="halDomain" n="stat">Statistics [stat]</classCode>
              <classCode scheme="halDomain" n="stat.ot">Statistics [stat]/Other Statistics [stat.ML]</classCode>
              <classCode scheme="halDomain" n="stat.me">Statistics [stat]/Methodology [stat.ME]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Background: Manual abstraction of real-world data (RWD) from unstructured health records (HRs) remains resource-intensive, error-prone, and highly variable across institutions. Large language models (LLMs) offer a scalable alternative, but their performance in multicenter oncology settings is not fully validated.Patients and methods: We conducted a multicenter study within the French Large &amp;amp; Unified Cancer Cohort (LUCC) consortium to compare the accuracy of artificial intelligence (AI)-based data extraction against manual abstraction by clinical research professionals. A fine-tuned LLM was applied to de-identified unstructured HRs in PDF format to extract 31 variables from lung cancer patients across 10 centers. Ground truth was defined as concordant values across sources, with discrepant cases adjudicated by a blinded expert. The primary endpoint was the extraction error rates. Secondary endpoints included per-variable performance, inter-institutional variability, F1-score for multiple-choice variables, added value of hybrid AI-human workflows, and survival analyses.Results: Among 10,327 patients with AI-based extraction, 311 were included in the test cohort. Across 8,708 datapoints for 28 variables with only one correct answer, the LLM achieved a 7.0% error rate, outperforming manual abstraction (14.2%, p&amp;lt;0.001). The F1-scores of 3 multiple-choice variables were superior (gene alterations 0.97 vs 0.86, comorbidities 0.86 vs 0.76, metastatic sites 0.71 vs 0.69). Inter-institutional variance was lower with AI (0.12% vs 0.39%). A hybrid approach with targeted human review of 30% of low-confidence AI outputs further decreased error rates to 4.4%. Survival analyses based on AI-extracted data closely matched ground truth, with similar median overall and progression-free survival.Conclusions: In a multicenter setting, our AI pipeline yielded lower error rates and greater consistency than manual abstraction. These findings support the feasibility of next-generation, AI-enabled multicenter studies to generate high-quality RWD at scale, with potential applicability in prospective clinical trials.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="researchteam" xml:id="struct-1051146" status="VALID">
          <orgName>Plateforme de Bioinformatique [Gustave Roussy]</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-1051142" type="direct"/>
            <relation active="#struct-156104" type="indirect"/>
            <relation name="US23" active="#struct-303623" type="indirect"/>
            <relation active="#struct-419361" type="indirect"/>
            <relation name="UAR3655 / UMS3655" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-531263" status="VALID">
          <idno type="RNSR">196317869N</idno>
          <orgName>Médicaments et Technologies pour la Santé</orgName>
          <orgName type="acronym">MTS</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>CEA- SPI- Bât. 136 Saclay 91191 GIF-SUR-YVETTE</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www6.jouy.inrae.fr/immuno_allergie_alimentaire/Presentation</ref>
          </desc>
          <listRelation>
            <relation active="#struct-419361" type="direct"/>
            <relation active="#struct-487603" type="direct"/>
            <relation name="DRF" active="#struct-300016" type="indirect"/>
            <relation name="UMR0496" active="#struct-577435" type="direct"/>
          </listRelation>
        </org>
        <org type="department" xml:id="struct-28519" status="VALID">
          <orgName>Département de médecine oncologique [Gustave Roussy]</orgName>
          <orgName type="acronym">DMO</orgName>
          <desc>
            <address>
              <addrLine>Gustave Roussy. 114, rue Édouard-Vaillant 94805 Villejuif Cedex -France</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-156104" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-1077089" status="VALID">
          <orgName>Hôpitaux La Rochelle Ré Aunis [Groupe hospitalier littoral Atlantique]</orgName>
          <desc>
            <address>
              <addrLine>Hôpital de la La Rochelle,  rue du Dr Albert Schweitzer, 17000 La Rochelle</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ch-larochelle.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1085260" status="VALID">
          <idno type="IdRef">189169206</idno>
          <idno type="ISNI">0000 0004 0629 8178</idno>
          <idno type="RNSR">200816529L</idno>
          <idno type="ROR">https://ror.org/003g1aw90</idno>
          <idno type="Wikidata">Q30262224</idno>
          <orgName>Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers</orgName>
          <orgName type="acronym">CRCI2NA</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>CRCI²NA - Institut de Recherche en Santé de Nantes Université, 8 quai Moncousu - BP 70721 - 44 007 Nantes Cedex 1 - France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://crci2na.univ-nantes.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-74911" type="direct"/>
            <relation name="U1307" active="#struct-303623" type="direct"/>
            <relation name="UMR6075" active="#struct-441569" type="direct"/>
            <relation active="#struct-1088522" type="direct"/>
            <relation active="#struct-1083368" type="indirect"/>
            <relation active="#struct-1083366" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-347702" status="VALID">
          <idno type="ROR">https://ror.org/03htsdy94</idno>
          <orgName>Centre Hospitalier de la Côte Basque</orgName>
          <orgName type="acronym">CHCB</orgName>
          <desc>
            <address>
              <addrLine>13 Avenue Jacques LoebBP 8, 64109 Bayonne Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.ch-cote-basque.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1041767" status="VALID">
          <orgName>Hypertension pulmonaire : physiopathologie et innovation thérapeutique</orgName>
          <orgName type="acronym">HPPIT</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>UMR 999 / UMR_S 1358 - Faculté de Médecine Paris-Saclay, Bâtiment Recherche, 63 rue Gabriel Péri, 94270 Le Kremlin Bicêtre / Centre Chirurgical Marie Lannelongue, 133 avenue de la Résistance, 92350, Le Plessis Robinson</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.hppit.fr/home</ref>
          </desc>
          <listRelation>
            <relation name="UMR_S 1358" active="#struct-303623" type="direct"/>
            <relation name="UMR 999" active="#struct-419361" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-419361" status="VALID">
          <idno type="IdRef">241345251</idno>
          <idno type="ROR">https://ror.org/03xjwb503</idno>
          <orgName>Université Paris-Saclay</orgName>
          <desc>
            <address>
              <addrLine>Bâtiment Bréguet, 3 Rue Joliot Curie 2e ét, 91190 Gif-sur-Yvette</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-paris-saclay.fr/fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-322615" status="VALID">
          <idno type="ROR">https://ror.org/02ndr3r66</idno>
          <orgName>Hôpital Marie-Lannelongue</orgName>
          <date type="start">1977-01-01</date>
          <desc>
            <address>
              <addrLine>133 avenue de la Résistance, 92350 Le Plessis-Robinson</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.hopitalmarielannelongue.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-499039" status="VALID">
          <idno type="IdRef">030608880</idno>
          <orgName>Centre hospitalier d'Auxerre</orgName>
          <orgName type="acronym">CHA</orgName>
          <desc>
            <address>
              <addrLine>2 bd de Verdun89011 AUXERRE Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.ght-unyon.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300185" status="VALID">
          <idno type="IdRef">031245382</idno>
          <idno type="ISNI">0000000404720160</idno>
          <idno type="ROR">https://ror.org/027arzy69</idno>
          <idno type="Wikidata">Q2945740</idno>
          <orgName>CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie</orgName>
          <orgName type="acronym">CHU Caen Normandie</orgName>
          <desc>
            <address>
              <addrLine>Avenue de la Côte de Nacre 14000 Caen</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-caen.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-455934" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-302301" status="VALID">
          <orgName>Centre Hospitalier de Versailles André Mignot</orgName>
          <orgName type="acronym">CHV</orgName>
          <desc>
            <address>
              <addrLine>Versailles, Trappes, Andrésy et Bois d'Arcy, Chesnay</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.ch-versailles.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-357527" status="VALID">
          <orgName>Centre Hospitalier Henri Duffaut [Avignon]</orgName>
          <orgName type="acronym">CH Avignon</orgName>
          <desc>
            <address>
              <addrLine>305A Rue Raoul Follereau, 84000 Avignon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.ch-avignon.fr/</ref>
          </desc>
        </org>
        <org type="department" xml:id="struct-541279" status="VALID">
          <orgName>Centre de référence des maladies rares de la peau et des muqueuses d’origine génétique [CHU Toulouse]</orgName>
          <orgName type="acronym">CRMRP</orgName>
          <desc>
            <address>
              <addrLine>Hôpital Larrey,  Service de dermatologie - 24, chemin de Pouvourville - 31059 Toulouse Cedex 09</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-toulouse.fr/-maladies-rares-de-la-peau-et-des-muqueuses-d-</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300075" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-456658" status="VALID">
          <orgName>Direction de la recherche [Gustave Roussy]</orgName>
          <desc>
            <address>
              <addrLine>Gustave Roussy. 114, rue Édouard-Vaillant 94805 Villejuif Cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-156104" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-322588" status="VALID">
          <idno type="IdRef">190563133</idno>
          <idno type="ROR">https://ror.org/046bx1082</idno>
          <orgName>Groupe Hospitalier Paris Saint-Joseph</orgName>
          <orgName type="acronym">hpsj</orgName>
          <date type="start">1878-01-01</date>
          <desc>
            <address>
              <addrLine>185, rue Raymond Losserand 75014 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.hpsj.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-353778" status="VALID">
          <idno type="ROR">https://ror.org/02mh9a093</idno>
          <orgName>CHU Pitié-Salpêtrière [AP-HP]</orgName>
          <desc>
            <address>
              <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-413221" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-413221" status="VALID">
          <idno type="IdRef">221333754</idno>
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Sorbonne Université</orgName>
          <orgName type="acronym">SU</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-universite.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1764632" status="INCOMING">
          <orgName>Lifen [Paris]</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-357472" status="VALID">
          <idno type="ROR">https://ror.org/044d2hn91</idno>
          <orgName>Centre Hospitalier Guillaume Régnier [Rennes]</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1051097" status="VALID">
          <idno type="IdRef">156182254</idno>
          <idno type="ISNI">0000 0004 0638 6872 </idno>
          <idno type="RNSR">201019083D</idno>
          <idno type="ROR">https://ror.org/01ed4t417</idno>
          <orgName>Centre de recherche en épidémiologie et santé des populations</orgName>
          <orgName type="acronym">CESP</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>16 avenue Paul Vaillant Couturier 94807 Villejuif Cedex, France</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="UMR U1018" active="#struct-81173" type="direct"/>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-300153" type="direct"/>
            <relation active="#struct-1066727" type="indirect"/>
            <relation name="U1018" active="#struct-303623" type="direct"/>
            <relation active="#struct-419361" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-1051100" status="VALID">
          <orgName>Oncostat</orgName>
          <orgName type="acronym">U1018 (Équipe 2) - CESP</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Gustave Roussy.114 rue Édouard Vaillant, 94805 Villejuif Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.gustaveroussy.fr/fr/node/2302</ref>
          </desc>
          <listRelation>
            <relation active="#struct-156104" type="direct"/>
            <relation active="#struct-1051097" type="direct"/>
            <relation name="UMR U1018" active="#struct-81173" type="indirect"/>
            <relation active="#struct-300068" type="indirect"/>
            <relation active="#struct-300153" type="indirect"/>
            <relation active="#struct-1066727" type="indirect"/>
            <relation name="U1018" active="#struct-303623" type="indirect"/>
            <relation active="#struct-419361" type="indirect"/>
          </listRelation>
        </org>
        <org type="department" xml:id="struct-59772" status="VALID">
          <orgName>Service de biostatistique et d'épidémiologie</orgName>
          <orgName type="acronym">SBE</orgName>
          <desc>
            <address>
              <addrLine>Gustave Roussy. 114, rue Édouard-Vaillant. 94805 Villejuif Cedex - France</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-456659" type="direct"/>
            <relation active="#struct-156104" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1042019" status="VALID">
          <orgName>Prédicteurs moléculaires et nouvelles cibles en oncologie</orgName>
          <orgName type="acronym">PMNCO (U981)</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Bâtiment de médecine moléculaire, Niveau 1, 114 rue Edouard Vaillant,94800, Villejuif</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-156104" type="direct"/>
            <relation name="U981" active="#struct-303623" type="direct"/>
            <relation active="#struct-419361" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1051142" status="VALID">
          <idno type="RNSR">201420837T</idno>
          <idno type="ROR">03ef0j886</idno>
          <orgName>Analyse moléculaire, modélisation et imagerie de la maladie cancéreuse</orgName>
          <orgName type="acronym">AMMICa</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Gustave-Roussy114, rue Édouard Vaillant94805 Villejuif</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://intranet.gustaveroussy.fr/index.php?p_id=51</ref>
          </desc>
          <listRelation>
            <relation active="#struct-156104" type="direct"/>
            <relation name="US23" active="#struct-303623" type="direct"/>
            <relation active="#struct-419361" type="direct"/>
            <relation name="UAR3655 / UMS3655" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-156104" status="VALID">
          <idno type="IdRef">026387433</idno>
          <idno type="ROR">https://ror.org/0321g0743</idno>
          <orgName>Institut Gustave Roussy</orgName>
          <orgName type="acronym">IGR</orgName>
          <desc>
            <address>
              <addrLine>114, rue Édouard-Vaillant 94805 Villejuif Cedex -France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.gustaveroussy.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-487603" status="VALID">
          <idno type="IdRef">262253712</idno>
          <idno type="RNSR">201722498K</idno>
          <idno type="ROR">https://ror.org/016pnwd02</idno>
          <idno type="Wikidata">Q61933008</idno>
          <orgName>Institut des Sciences du Vivant Frédéric JOLIOT</orgName>
          <orgName type="acronym">JOLIOT</orgName>
          <date type="start">2017-01-01</date>
          <desc>
            <address>
              <addrLine>DRFCEAGif-sur-Yvette</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="DRF" active="#struct-300016" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300016" status="VALID">
          <idno type="IdRef">026372061</idno>
          <idno type="ISNI">0000000122998025</idno>
          <idno type="ROR">https://ror.org/00jjx8s55</idno>
          <idno type="Wikidata">Q868550</idno>
          <orgName>Commissariat à l'énergie atomique et aux énergies alternatives</orgName>
          <orgName type="acronym">CEA</orgName>
          <desc>
            <address>
              <addrLine>Centre de SaclayCentre de GrenobleCentre de Cadaracheetc</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cea.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-577435" status="VALID">
          <idno type="ROR">https://ror.org/003vg9w96</idno>
          <orgName>Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement</orgName>
          <orgName type="acronym">INRAE</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-74911" status="VALID">
          <idno type="IdRef">026402920</idno>
          <idno type="ISNI">0000000122483363</idno>
          <idno type="ROR">https://ror.org/04yrqp957</idno>
          <orgName>Université d'Angers</orgName>
          <orgName type="acronym">UA</orgName>
          <date type="start">1971-10-25</date>
          <desc>
            <address>
              <addrLine>Université d'Angers - 40 Rue de Rennes, BP 73532 - 49035 Angers CEDEX 01</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-angers.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-1088522" status="VALID">
          <idno type="IdRef">076954927</idno>
          <orgName>Nantes Université - UFR de Médecine et des Techniques Médicales</orgName>
          <orgName type="acronym">Nantes Univ - UFR MEDECINE</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>1 rue Gaston Veil BP 53508 44035 NANTES Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.medecine.univ-nantes.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1083368" type="direct"/>
            <relation active="#struct-1083366" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-1083368" status="VALID">
          <orgName>Nantes Université - pôle Santé</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://nouvelleuniversite.univ-nantes.fr/les-poles</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1083366" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-1083366" status="VALID">
          <idno type="IdRef">258086599</idno>
          <idno type="ROR">https://ror.org/03gnr7b55</idno>
          <orgName>Nantes Université</orgName>
          <orgName type="acronym">Nantes Univ</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-455934" status="VALID">
          <idno type="IdRef">190906332</idno>
          <idno type="ISNI">0000000417859671 </idno>
          <idno type="ROR">https://ror.org/01k40cz91</idno>
          <orgName>Normandie Université</orgName>
          <orgName type="acronym">NU</orgName>
          <date type="start">2015-01-01</date>
          <desc>
            <address>
              <addrLine>Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.normandie-univ.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300075" status="VALID">
          <orgName>Centre Hospitalier Universitaire de Toulouse</orgName>
          <orgName type="acronym">CHU Toulouse</orgName>
          <desc>
            <address>
              <addrLine>regroupe les hôpitaux  Purpan, Rangueil, Pierre-Paul Riquet, Larey, Paule de Viguier, Hôtel Dieu Saint-Jacques, La Grave, etc.</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-toulouse.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-81173" status="VALID">
          <idno type="IdRef">03082057X</idno>
          <idno type="ISNI">0000 0001 2323 0229 </idno>
          <idno type="ROR">https://ror.org/03mkjjy25</idno>
          <orgName>Université de Versailles Saint-Quentin-en-Yvelines</orgName>
          <orgName type="acronym">UVSQ</orgName>
          <date type="start">1991-07-22</date>
          <desc>
            <address>
              <addrLine>55 avenue de Paris - 78035 Versailles cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.uvsq.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300153" status="VALID">
          <idno type="ROR">https://ror.org/05n7yzd13</idno>
          <orgName>Hôpital Paul Brousse</orgName>
          <desc>
            <address>
              <addrLine>12 Avenue Paul Vaillant Couturier, 94800 Villejuif</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-1066727" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-1066727" status="VALID">
          <orgName>AP-HP. Université Paris Saclay</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.aphp.fr/groupes-hospitaliers-de-lap-hp</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-456659" status="VALID">
          <orgName>Direction de la recherche clinique [Gustave Roussy]</orgName>
          <desc>
            <address>
              <addrLine>Gustave Roussy. 114, rue Édouard-Vaillant 94805 Villejuif Cedex -France</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-156104" type="direct"/>
          </listRelation>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>