<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of inserm-05031576</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-06T21:54:57+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">The impact of Charcot-Leyden Crystal protein on mesothelioma chemotherapy: targeting eosinophils for enhanced chemosensitivity</title>
            <author role="aut">
              <persName>
                <forename type="first">Mégane</forename>
                <surname>Willems</surname>
              </persName>
              <idno type="idhal" notation="numeric">1521741</idno>
              <idno type="halauthorid" notation="string">3450150-1521741</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0319-5600</idno>
              <affiliation ref="#struct-93075"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Malik</forename>
                <surname>Hamaidia</surname>
              </persName>
              <idno type="halauthorid">3145365-0</idno>
              <affiliation ref="#struct-93075"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alexis</forename>
                <surname>Fontaine</surname>
              </persName>
              <idno type="idhal" notation="numeric">1521742</idno>
              <idno type="halauthorid" notation="string">3450151-1521742</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5135-5982</idno>
              <affiliation ref="#struct-93075"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mélanie</forename>
                <surname>Grégoire</surname>
              </persName>
              <idno type="halauthorid">3450152-0</idno>
              <affiliation ref="#struct-93075"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Louise</forename>
                <surname>Halkin</surname>
              </persName>
              <idno type="halauthorid">3450153-0</idno>
              <affiliation ref="#struct-93075"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Lea</forename>
                <surname>Vilanova Mañá</surname>
              </persName>
              <idno type="halauthorid">3450154-0</idno>
              <affiliation ref="#struct-93075"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Roxane</forename>
                <surname>Terres</surname>
              </persName>
              <idno type="halauthorid">3450155-0</idno>
              <affiliation ref="#struct-93075"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Majeed</forename>
                <surname>Jamakhani</surname>
              </persName>
              <idno type="halauthorid">2665000-0</idno>
              <affiliation ref="#struct-93075"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sophie</forename>
                <surname>Deshayes</surname>
              </persName>
              <idno type="halauthorid">1022434-0</idno>
              <affiliation ref="#struct-477534"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yves</forename>
                <surname>Brostaux</surname>
              </persName>
              <idno type="halauthorid">2547544-0</idno>
              <affiliation ref="#struct-93075"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Vincent</forename>
                <surname>Heinen</surname>
              </persName>
              <idno type="halauthorid">3450156-0</idno>
              <affiliation ref="#struct-309360"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Renaud</forename>
                <surname>Louis</surname>
              </persName>
              <idno type="halauthorid">1720428-0</idno>
              <affiliation ref="#struct-309360"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Bernard</forename>
                <surname>Duysinx</surname>
              </persName>
              <idno type="halauthorid">3375687-0</idno>
              <affiliation ref="#struct-309360"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Didier</forename>
                <surname>Jean</surname>
              </persName>
              <email type="md5">ce1c5ef01e50d00eb2212795fe25b2dc</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">didier-jean</idno>
              <idno type="idhal" notation="numeric">182946</idno>
              <idno type="halauthorid" notation="string">10559-182946</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/A-1615-2009</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5823-7404</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/A-1615-2009</idno>
              <affiliation ref="#struct-1004777"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Eric</forename>
                <surname>Wasielewski</surname>
              </persName>
              <idno type="halauthorid">1983421-0</idno>
              <affiliation ref="#struct-489340"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Arnaud</forename>
                <surname>Scherpereel</surname>
              </persName>
              <idno type="halauthorid">408129-0</idno>
              <affiliation ref="#struct-489340"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christophe</forename>
                <surname>Blanquart</surname>
              </persName>
              <email type="md5">fb6216f3a77a86808c4deb6564adb858</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">christophe-blanquart</idno>
              <idno type="idhal" notation="numeric">182432</idno>
              <idno type="halauthorid" notation="string">19973-182432</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0917-3747</idno>
              <idno type="IDREF">https://www.idref.fr/079241417</idno>
              <affiliation ref="#struct-1123526"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Luc</forename>
                <surname>Willems</surname>
              </persName>
              <idno type="halauthorid">146288-0</idno>
              <affiliation ref="#struct-93075"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Didier</forename>
                <surname>Jean</surname>
              </persName>
              <email type="md5">ce1c5ef01e50d00eb2212795fe25b2dc</email>
              <email type="domain">inserm.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2025-04-11 23:31:55</date>
              <date type="whenModified">2026-04-23 14:00:51</date>
              <date type="whenReleased">2025-05-06 15:53:54</date>
              <date type="whenProduced">2024-11</date>
              <date type="whenEndEmbargoed">2025-05-06</date>
              <ref type="file" target="https://inserm.hal.science/inserm-05031576v1/document">
                <date notBefore="2025-05-06"/>
              </ref>
              <ref type="file" subtype="publisherPaid" n="1" target="https://inserm.hal.science/inserm-05031576v1/file/1-s2.0-S2352396424004547-main.pdf" id="file-5031576-4378223">
                <date notBefore="2025-05-06"/>
              </ref>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11550731"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="156072">
                <persName>
                  <forename>Didier</forename>
                  <surname>Jean</surname>
                </persName>
                <email type="md5">ce1c5ef01e50d00eb2212795fe25b2dc</email>
                <email type="domain">inserm.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">inserm-05031576</idno>
            <idno type="halUri">https://inserm.hal.science/inserm-05031576</idno>
            <idno type="halBibtex">willems:inserm-05031576</idno>
            <idno type="halRefHtml">&lt;i&gt;EBioMedicine&lt;/i&gt;, 2024, 109 (4), pp.105418. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.ebiom.2024.105418"&gt;&amp;#x27E8;10.1016/j.ebiom.2024.105418&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">EBioMedicine, 2024, 109 (4), pp.105418. &amp;#x27E8;10.1016/j.ebiom.2024.105418&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0 - Attribution<ref corresp="#file-5031576-4378223"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="EPHE">École Pratique des Hautes Études</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-ANGERS">Université d'Angers</idno>
            <idno type="stamp" n="CORDELIERS" corresp="SORBONNE-UNIVERSITE">Centre de recherche des Cordeliers</idno>
            <idno type="stamp" n="PSL">Université Paris sciences et lettres</idno>
            <idno type="stamp" n="CRCINA" corresp="INSERM">Centre de Recherche en Cancérologie et Immunologie Nantes Angers</idno>
            <idno type="stamp" n="UNIV-LILLE">Université de Lille</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="SORBONNE-UNIV" corresp="SORBONNE-UNIVERSITE">Sorbonne Université 01/01/2018</idno>
            <idno type="stamp" n="SU-SCIENCES" corresp="SORBONNE-UNIVERSITE">Faculté des Sciences de Sorbonne Université</idno>
            <idno type="stamp" n="TEST-DEV">TEST-DEV</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS" corresp="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UP-SANTE">Université Paris Cité - Faculté de Santé</idno>
            <idno type="stamp" n="EPHE-PSL" corresp="PSL">École Pratique des Hautes Études - PSL</idno>
            <idno type="stamp" n="ONCO-THAI">Thérapies Laser Assistées par l'Image pour l'Oncologie</idno>
            <idno type="stamp" n="SU-TI">Sorbonne Université - Texte Intégral</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
            <idno type="stamp" n="CRCI2NA">Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers</idno>
            <idno type="stamp" n="NANTES-UNIVERSITE">Nantes Université</idno>
            <idno type="stamp" n="NANTES-UNIV">Nantes Université</idno>
            <idno type="stamp" n="UFR-MEDECINE-NANTES">UFR de médecine - Nantes Université</idno>
            <idno type="stamp" n="SUPRA_BIOLOGIE">Biologie hors MNHN &amp; stations</idno>
            <idno type="stamp" n="CRCI2NA-EQUIPE-1">Immunomodulation of the Tumor Microenvironment and Immunotherapy of Thoracic Cancers </idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">The impact of Charcot-Leyden Crystal protein on mesothelioma chemotherapy: targeting eosinophils for enhanced chemosensitivity</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Mégane</forename>
                    <surname>Willems</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1521741</idno>
                  <idno type="halauthorid" notation="string">3450150-1521741</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0319-5600</idno>
                  <affiliation ref="#struct-93075"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Malik</forename>
                    <surname>Hamaidia</surname>
                  </persName>
                  <idno type="halauthorid">3145365-0</idno>
                  <affiliation ref="#struct-93075"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alexis</forename>
                    <surname>Fontaine</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1521742</idno>
                  <idno type="halauthorid" notation="string">3450151-1521742</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5135-5982</idno>
                  <affiliation ref="#struct-93075"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mélanie</forename>
                    <surname>Grégoire</surname>
                  </persName>
                  <idno type="halauthorid">3450152-0</idno>
                  <affiliation ref="#struct-93075"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Louise</forename>
                    <surname>Halkin</surname>
                  </persName>
                  <idno type="halauthorid">3450153-0</idno>
                  <affiliation ref="#struct-93075"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lea</forename>
                    <surname>Vilanova Mañá</surname>
                  </persName>
                  <idno type="halauthorid">3450154-0</idno>
                  <affiliation ref="#struct-93075"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Roxane</forename>
                    <surname>Terres</surname>
                  </persName>
                  <idno type="halauthorid">3450155-0</idno>
                  <affiliation ref="#struct-93075"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Majeed</forename>
                    <surname>Jamakhani</surname>
                  </persName>
                  <idno type="halauthorid">2665000-0</idno>
                  <affiliation ref="#struct-93075"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sophie</forename>
                    <surname>Deshayes</surname>
                  </persName>
                  <idno type="halauthorid">1022434-0</idno>
                  <affiliation ref="#struct-477534"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yves</forename>
                    <surname>Brostaux</surname>
                  </persName>
                  <idno type="halauthorid">2547544-0</idno>
                  <affiliation ref="#struct-93075"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Vincent</forename>
                    <surname>Heinen</surname>
                  </persName>
                  <idno type="halauthorid">3450156-0</idno>
                  <affiliation ref="#struct-309360"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Renaud</forename>
                    <surname>Louis</surname>
                  </persName>
                  <idno type="halauthorid">1720428-0</idno>
                  <affiliation ref="#struct-309360"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Bernard</forename>
                    <surname>Duysinx</surname>
                  </persName>
                  <idno type="halauthorid">3375687-0</idno>
                  <affiliation ref="#struct-309360"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Didier</forename>
                    <surname>Jean</surname>
                  </persName>
                  <email type="md5">ce1c5ef01e50d00eb2212795fe25b2dc</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">didier-jean</idno>
                  <idno type="idhal" notation="numeric">182946</idno>
                  <idno type="halauthorid" notation="string">10559-182946</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/A-1615-2009</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5823-7404</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/A-1615-2009</idno>
                  <affiliation ref="#struct-1004777"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Eric</forename>
                    <surname>Wasielewski</surname>
                  </persName>
                  <idno type="halauthorid">1983421-0</idno>
                  <affiliation ref="#struct-489340"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Arnaud</forename>
                    <surname>Scherpereel</surname>
                  </persName>
                  <idno type="halauthorid">408129-0</idno>
                  <affiliation ref="#struct-489340"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christophe</forename>
                    <surname>Blanquart</surname>
                  </persName>
                  <email type="md5">fb6216f3a77a86808c4deb6564adb858</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">christophe-blanquart</idno>
                  <idno type="idhal" notation="numeric">182432</idno>
                  <idno type="halauthorid" notation="string">19973-182432</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0917-3747</idno>
                  <idno type="IDREF">https://www.idref.fr/079241417</idno>
                  <affiliation ref="#struct-1123526"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Luc</forename>
                    <surname>Willems</surname>
                  </persName>
                  <idno type="halauthorid">146288-0</idno>
                  <affiliation ref="#struct-93075"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">105850</idno>
                <idno type="issn">2352-3964</idno>
                <title level="j">EBioMedicine</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">109</biblScope>
                  <biblScope unit="issue">4</biblScope>
                  <biblScope unit="pp">105418</biblScope>
                  <date type="datePub">2024-11</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.ebiom.2024.105418</idno>
              <idno type="pubmed">39471751</idno>
              <idno type="pubmedcentral">PMC11550731</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Charcot-leyden crystal protein</term>
                <term xml:lang="en">Chemoresistance</term>
                <term xml:lang="en">Eosinophils</term>
                <term xml:lang="en">Mesothelioma.</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Background: In mesothelioma (MPM), clinical evidence indicates that the absolute eosinophil count negatively correlates with overall survival and response to standard chemotherapy. Since eosinophils poorly infiltrate MPM tumours, we hypothesised that endocrine rather than paracrine pathways mediate the therapeutic response. We thus studied the effect of eosinophil-associated factors on response to chemotherapy in mesothelioma.Methods: The culture supernatant conditioned by primary human eosinophils was added to mesothelioma cells in presence of the standard chemotherapeutic regimen. The effectiveness of an anti-eosinophil treatment was evaluated in a preclinical model of C57BL/6 mice transplanted with mesothelioma tumour cells.Findings: Supernatant of eosinophils differentiated from EOL1 cells or directly isolated from peripheral blood inhibited apoptosis induced by cisplatin and pemetrexed in 2D cultures and in spheroids. Transcriptomic analysis indicated that the anti-apoptotic effect mediated by eosinophils involved molecular interactions with the Charcot-Leyden Crystal protein or Galectin-10 (CLC-P/Gal10). The functional relevance of CLC-P/Gal10 was demonstrated by antibody-mediated depletion. Recombinant human CLC-P/Gal10 mimicked the anti-apoptotic activity of eosinophil-derived supernatants. In the mouse model, eosinophilia did not significantly affect tumour growth but altered the response to chemotherapy. Finally, pretreatment of eosinophilia with the anti-Siglec-F antibody before chemotherapy restored the effectiveness of the treatment.Interpretation: This study provides a mechanistic rationale to clinical evidence correlating the poor outcome of patients with mesothelioma and with eosinophil-derived CLC-P/Gal10, opening new prospects for intervention in this fatal solid tumour.Funding: Belgian Foundation against Cancer, Fonds National de la Recherche Scientifique (FNRS), Télévie, Foundation Léon Fredericq, ULiège.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-93075" status="VALID">
          <idno type="IdRef">026431416</idno>
          <idno type="ISNI">0000000108057253</idno>
          <idno type="ROR">https://ror.org/00afp2z80</idno>
          <idno type="Wikidata">Q1334582</idno>
          <orgName>Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich</orgName>
          <orgName type="acronym">ULiège</orgName>
          <date type="start">1817-01-01</date>
          <desc>
            <address>
              <addrLine>Place du 20-Août, 7 4000 Liège</addrLine>
              <country key="BE"/>
            </address>
            <ref type="url">http://www.ulg.ac.be/cms/c_5000/accueil</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-477534" status="OLD">
          <idno type="IdRef">189169206</idno>
          <idno type="RNSR">200816529L</idno>
          <orgName>Centre de Recherche en Cancérologie et Immunologie Nantes-Angers</orgName>
          <orgName type="acronym">CRCINA</orgName>
          <date type="start">2017-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.crcina.org/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-74911" type="direct"/>
            <relation active="#struct-303623" type="direct"/>
            <relation active="#struct-441569" type="direct"/>
            <relation active="#struct-474972" type="direct"/>
            <relation active="#struct-531638" type="direct"/>
            <relation active="#struct-93263" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-309360" status="VALID">
          <orgName>Centre Hospitalier Universitaire de Liège</orgName>
          <orgName type="acronym">CHU-Liège</orgName>
          <desc>
            <address>
              <country key="BE"/>
            </address>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1004777" status="VALID">
          <idno type="IdRef">158039203</idno>
          <idno type="ISNI">0000 0004 0620 5824 </idno>
          <idno type="RNSR">200716512X</idno>
          <orgName>Centre de Recherche des Cordeliers</orgName>
          <orgName type="acronym">CRC (UMR_S_1138 / U1138)</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>15 rue de l'Ecole de Médecine - Bâtiment B - 75270 Paris Cedex 06</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.crc.jussieu.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-110691" type="direct"/>
            <relation active="#struct-564132" type="indirect"/>
            <relation name="U1138" active="#struct-303623" type="direct"/>
            <relation active="#struct-413221" type="direct"/>
            <relation name="UMR_S_1138" active="#struct-557826" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-489340" status="VALID">
          <idno type="IdRef">191293180</idno>
          <idno type="ISNI">0000 0004 7780 8884</idno>
          <idno type="RNSR">199817738U</idno>
          <idno type="ROR">https://ror.org/04q29nn62</idno>
          <idno type="Wikidata">Q116959464</idno>
          <orgName>Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189</orgName>
          <orgName type="acronym">OncoThAI</orgName>
          <date type="start">1998-01-01</date>
          <desc>
            <address>
              <addrLine>OncoThAI - Faculté de Médecine - 1 avenue Oscar Lambret- 59037 Lille Cedex.</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.oncothai.fr/fr/</ref>
          </desc>
          <listRelation>
            <relation name="U1189" active="#struct-303623" type="direct"/>
            <relation name="U1189" active="#struct-374570" type="direct"/>
            <relation name="U703" active="#struct-425779" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-1123526" status="VALID">
          <orgName>Immunomodulation of the Tumor Microenvironment and Immunotherapy of Thoracic Cancers</orgName>
          <orgName type="acronym">CRCI2NA / Eq 1</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://crci2na.univ-nantes.fr/en/research/team-1</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1085260" type="direct"/>
            <relation active="#struct-74911" type="indirect"/>
            <relation name="U1307" active="#struct-303623" type="indirect"/>
            <relation name="UMR6075" active="#struct-441569" type="indirect"/>
            <relation active="#struct-1088522" type="indirect"/>
            <relation active="#struct-1083368" type="indirect"/>
            <relation active="#struct-1083366" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-74911" status="VALID">
          <idno type="IdRef">026402920</idno>
          <idno type="ISNI">0000000122483363</idno>
          <idno type="ROR">https://ror.org/04yrqp957</idno>
          <orgName>Université d'Angers</orgName>
          <orgName type="acronym">UA</orgName>
          <date type="start">1971-10-25</date>
          <desc>
            <address>
              <addrLine>Université d'Angers - 40 Rue de Rennes, BP 73532 - 49035 Angers CEDEX 01</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-angers.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-474972" status="VALID">
          <idno type="IdRef">034926445</idno>
          <idno type="ROR">https://ror.org/05c1qsg97</idno>
          <idno type="Wikidata">Q2945767</idno>
          <orgName>Centre Hospitalier Universitaire de Nantes = Nantes University Hospital</orgName>
          <orgName type="acronym">CHU Nantes</orgName>
          <desc>
            <address>
              <addrLine>1 Place Alexis-Ricordeau, 44000 Nantes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-nantes.fr</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-531638" status="OLD">
          <idno type="IdRef">076954927</idno>
          <orgName>Université de Nantes - UFR de Médecine et des Techniques Médicales</orgName>
          <orgName type="acronym">UFR MEDECINE</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>1 rue Gaston Veil BP 53508 44035 NANTES Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.medecine.univ-nantes.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-93263" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-93263" status="OLD">
          <idno type="IdRef">026403447</idno>
          <idno type="ROR">https://ror.org/03gnr7b55</idno>
          <orgName>Université de Nantes</orgName>
          <orgName type="acronym">UN</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>1, quai de Tourville - BP 13522 - 44035 Nantes cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-nantes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-110691" status="VALID">
          <idno type="IdRef">026375478</idno>
          <idno type="ISNI">0000000121955365</idno>
          <idno type="ROR">https://ror.org/046b3cj80</idno>
          <orgName>École Pratique des Hautes Études</orgName>
          <orgName type="acronym">EPHE</orgName>
          <date type="start">1868-01-01</date>
          <desc>
            <address>
              <addrLine>4-14 Rue Ferrus, 75014 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ephe.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-564132" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-564132" status="VALID">
          <idno type="IdRef">241597595</idno>
          <idno type="ISNI">0000 0004 1784 3645</idno>
          <idno type="ROR">https://ror.org/013cjyk83</idno>
          <orgName>Université Paris Sciences et Lettres</orgName>
          <orgName type="acronym">PSL</orgName>
          <desc>
            <address>
              <addrLine>60 rue Mazarine 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.psl.eu/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-413221" status="VALID">
          <idno type="IdRef">221333754</idno>
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Sorbonne Université</orgName>
          <orgName type="acronym">SU</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-universite.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-557826" status="VALID">
          <idno type="IdRef">236453505</idno>
          <idno type="ISNI">0000 0004 7885 7602</idno>
          <idno type="ROR">https://ror.org/05f82e368</idno>
          <orgName>Université Paris Cité</orgName>
          <orgName type="acronym">UPCité</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>85 boulevard Saint-Germain75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://u-paris.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-374570" status="VALID">
          <idno type="IdRef">223446556</idno>
          <idno type="ISNI">0000 0001 2242 6780</idno>
          <idno type="ROR">https://ror.org/02kzqn938</idno>
          <idno type="Wikidata">Q3551621</idno>
          <orgName>Université de Lille</orgName>
          <desc>
            <address>
              <addrLine>EPE Université de Lille. -- 42 rue Paul Duez, 59000 Lille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-425779" status="VALID">
          <idno type="IdRef">034424636</idno>
          <idno type="ISNI">0000000404718845</idno>
          <idno type="ROR">https://ror.org/02ppyfa04</idno>
          <idno type="Wikidata">Q2945741</idno>
          <orgName>Centre Hospitalier Régional Universitaire [CHU Lille]</orgName>
          <orgName type="acronym">CHRU Lille</orgName>
          <desc>
            <address>
              <addrLine>CHU/CHRU Lille - 2, avenue Oscar Lambret - 59037 Lille Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chru-lille.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1085260" status="VALID">
          <idno type="IdRef">189169206</idno>
          <idno type="ISNI">0000 0004 0629 8178</idno>
          <idno type="RNSR">200816529L</idno>
          <idno type="ROR">https://ror.org/003g1aw90</idno>
          <idno type="Wikidata">Q30262224</idno>
          <orgName>Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers</orgName>
          <orgName type="acronym">CRCI2NA</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>CRCI²NA - Institut de Recherche en Santé de Nantes Université, 8 quai Moncousu - BP 70721 - 44 007 Nantes Cedex 1 - France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://crci2na.univ-nantes.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-74911" type="direct"/>
            <relation name="U1307" active="#struct-303623" type="direct"/>
            <relation name="UMR6075" active="#struct-441569" type="direct"/>
            <relation active="#struct-1088522" type="direct"/>
            <relation active="#struct-1083368" type="indirect"/>
            <relation active="#struct-1083366" type="indirect"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-1088522" status="VALID">
          <idno type="IdRef">076954927</idno>
          <orgName>Nantes Université - UFR de Médecine et des Techniques Médicales</orgName>
          <orgName type="acronym">Nantes Univ - UFR MEDECINE</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>1 rue Gaston Veil BP 53508 44035 NANTES Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.medecine.univ-nantes.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1083368" type="direct"/>
            <relation active="#struct-1083366" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-1083368" status="VALID">
          <orgName>Nantes Université - pôle Santé</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://nouvelleuniversite.univ-nantes.fr/les-poles</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1083366" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-1083366" status="VALID">
          <idno type="IdRef">258086599</idno>
          <idno type="ROR">https://ror.org/03gnr7b55</idno>
          <orgName>Nantes Université</orgName>
          <orgName type="acronym">Nantes Univ</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>