Article Dans Une Revue Journal of Hepatology Année : 2023

A global research priority agenda to advance public health responses to fatty liver disease

1 ISGlobal - Instituto de Salud Global - Institute For Global Health [Barcelona]
2 Open University of Catalonia [Barcelona]
3 The Graduate Center - CUNY Graduate Center
4 ILF - EASL International Liver Foundation [Geneva, Switzerland]
5 Mayo Clinic [Rochester]
6 UWO - University of Western Ontario
7 LHSC - London Health Sciences Center
8 UC - Pontificia Universidad Católica de Chile
9 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
10 ISSPAM - Institut des sciences de la santé publique [Marseille]
11 The Houston Methodist Research Institute
12 QMUL - Queen Mary University of London
13 ALH - Arizona Liver Health [Phoenix, Arizona, USA]
14 KFSH & RC - King Faisal Specialist Hospital and Research Centre
15 Clinic Barcelona Hospital Universitari
16 IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer
17 Leipzig University / Universität Leipzig
18 University of Dundee
19 AOUP - Azienda Ospedale Università di Padova = Hospital-University of Padua
20 Hospital Medica Sur [Mexico City, Mexico]
21 INCMNSZ - Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán - National Institute of Medical Science and Nutrition Salvador Zubiran [Mexico]
22 UAL - Universidade Autónoma de Lisboa
23 UF - University of Florida [Gainesville]
24 GPA - Greek Patients Association [Athens, Greece]
25 PIMER - Postgraduate Institute of Medical Education and Research [Chandigarh, India]
26 UZA - Antwerp University Hospital [Edegem]
27 UA - University of Antwerp
28 Karolinska Institutet [Stockholm]
29 Kautz 5 gUG [Köln, Germany]
30 IR - Independent researcher [Ponte de Lima, Portugal]
31 OUH - Odense University Hospital
32 UC Berkeley - University of California [Berkeley]
33 UHB-NHS Foundation - University Hospitals Birmingham NHS Foundation Trust [Birmingham, UK]
34 University of Birmingham [Birmingham]
35 University of Chicago
36 ILBS - Institute of Liver and Biliary Sciences [New Delhi, India]
37 Hospital Universitario Austral
38 University of Cape Town
39 Royal Free Hospital [London, UK]
40 Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico
41 University of Haifa [Haifa]
42 Tel Aviv Sourasky Medical Center [Tel Aviv]
43 University Medical Center [Mainz]
44 CUHK - The Chinese University of Hong Kong [Hong Kong]
45 CLD - Center For Liver Diseases [Falls Church, VA, USA]
Marco Arrese
Paul N Brennan
Helena Cortez-Pinto
Kenneth Cusi
Null- K Huang
Aleksander Krag
Veronica Miller
Diana Romero
C Wendy Spearman

Résumé

Background & aims: An estimated 38% of adults worldwide have non-alcoholic fatty liver disease (NAFLD). From individual impacts to widespread public health and economic consequences, the implications of this disease are profound. This study aimed to develop an aligned, prioritised fatty liver disease research agenda for the global health community. Methods: Nine co-chairs drafted initial research priorities, subsequently reviewed by 40 core authors and debated during a three-day in-person meeting. Following a Delphi methodology, over two rounds, a large panel (R1 n = 344, R2 n = 288) reviewed the priorities, via Qualtrics XM, indicating agreement using a four-point Likert-scale and providing written feedback. The core group revised the draft priorities between rounds. In R2, panellists also ranked the priorities within six domains: epidemiology, models of care, treatment and care, education and awareness, patient and community perspectives, and leadership and public health policy. Results: The consensus-built fatty liver disease research agenda encompasses 28 priorities. The mean percentage of 'agree' responses increased from 78.3 in R1 to 81.1 in R2. Five priorities received unanimous combined agreement ('agree' + 'somewhat agree'); the remaining 23 priorities had >90% combined agreement. While all but one of the priorities exhibited at least a super-majority of agreement (>66.7% 'agree'), 13 priorities had <80% 'agree', with greater reliance on 'somewhat agree' to achieve >90% combined agreement. Conclusions: Adopting this multidisciplinary consensus-built research priorities agenda can deliver a step-change in addressing fatty liver disease, mitigating against its individual and societal harms and proactively altering its natural history through prevention, identification, treatment, and care. This agenda should catalyse the global health community's efforts to advance and accelerate responses to this widespread and fast-growing public health threat. Impact and implications: An estimated 38% of adults and 13% of children and adolescents worldwide have fatty liver disease, making it the most prevalent liver disease in history. Despite substantial scientific progress in the past three decades, the burden continues to grow, with an urgent need to advance understanding of how to prevent, manage, and treat the disease. Through a global consensus process, a multidisciplinary group agreed on 28 research priorities covering a broad range of themes, from disease burden, treatment, and health system responses to awareness and policy. The findings have relevance for clinical and non-clinical researchers as well as funders working on fatty liver disease and non-communicable diseases more broadly, setting out a prioritised, ranked research agenda for turning the tide on this fast-growing public health threat.
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inserm-04546131 , version 1 (15-04-2024)

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Jeffrey V Lazarus, Henry E Mark, Alina M Allen, Juan Pablo Arab, Patrizia Carrieri, et al.. A global research priority agenda to advance public health responses to fatty liver disease. Journal of Hepatology, 2023, 79, pp.618 - 634. ⟨10.1016/j.jhep.2023.04.035⟩. ⟨inserm-04546131⟩
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