Cannabidiol (CBD) has a wide spectrum of potential therapeutic use and is growing in popularity. However, there is a need to characterize users, as associated benefits and risks may differ depending on the pattern of use. This study explored the characteristics of French and Italian CBD users according to their primary reason to use it. We analyzed data from an online survey of French (n = 1164) and Italian (n = 2608) cannabidiol users. We compared their characteristics according to their primary reason to use CBD, and identified correlates of therapeutic use with logistic regressions. In both countries, users’ characteristics differed according to their reasons to use CBD. Reporting therapeutic use was associated with daily CBD use and nonsmoking routes of administration in both countries. User profiles differed according to their primary reason to use it. However, similarities in characteristics were found between both countries for users who used CBD for therapeutic reasons. Accordingly, analyzing the reasons to use CBD would appear to be a pertinent way to characterize users and identify their unmet needs in terms of self-care.