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Article Dans Une Revue Frontiers in Cardiovascular Medicine Année : 2021

Serpins in Hemostasis as Therapeutic Targets for Bleeding or Thrombotic Disorders

Résumé

Bleeding and thrombotic disorders result from imbalances in coagulation or fibrinolysis, respectively. Inhibitors from the serine protease inhibitor (serpin) family have a key role in regulating these physiological events, and thus stand out as potential therapeutic targets for modulating fibrin clot formation or dismantling. Here, we review the diversity of serpin-targeting strategies in the area of hemostasis, and detail the suggested use of modified serpins and serpin inhibitors (ranging from small-molecule drugs to antibodies) to treat or prevent bleeding or thrombosis.
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inserm-04455122 , version 1 (13-02-2024)

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Elsa Bianchini, Claire Auditeau, Mahita Razanakolona, Marc Vasse, Delphine Borgel. Serpins in Hemostasis as Therapeutic Targets for Bleeding or Thrombotic Disorders. Frontiers in Cardiovascular Medicine, 2021, 7, pp.622778. ⟨10.3389/fcvm.2020.622778⟩. ⟨inserm-04455122⟩
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