Article Dans Une Revue (Data Paper) Rhinology Année : 2006

Matrix metalloproteinase-2 and -9 expression in sinonasal inverted papilloma.

Résumé

Statement of problem: Inverted papilloma (IP) is a proliferative lesion of the epithelium lining the sinonasal tract, characterized by marked propensity for recurrence and association with carcinoma. To determine a putative role of matrix metalloproteinase-2 (MMP-2) and MMP-9 in the establishment of IP, their expression was studied in IP. Methods: Archived surgical specimens from 15 IPs were studied using immunohistochemistry and compared to 12 nasal polyps (NP), a model of chronic respiratory mucosal inflammation, and to 6 control nasal mucosa (CM) samples obtained from snorers during turbinectomy. Within IP, MMP-2 and -9 expression was compared between tumoral areas with hyperplastic epithelium and non tumoral areas with nonhyperplastic epithelium. Results: In IP, MMP-2 and MMP-9 epithelial expression was not different compared to CM and NP. MMP-9 expression in submucosal inflammatory cells was not different between IP and CM or NP. However, within IP, a significantly increased number of MMP-9 positive inflammatory cells in the lamina propria adjacent to the hyperplastic epithelium was observed compared to the lamina propria adjacent to nonhyperplastic epithelium. Conclusion: Our findings suggest that MMP 9 expressing inflammatory cells may be involved in the pathophysiology of IP.
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Dates et versions

inserm-04145287 , version 1 (29-06-2023)

Identifiants

  • HAL Id : inserm-04145287 , version 1
  • PUBMED : 17020070
  • WOS : 000240963100008

Citer

Jean-Francois Papon, E Lechapt-Zalcman, M Abina, I Abd-Al-Sama, R Peynègre, et al.. Matrix metalloproteinase-2 and -9 expression in sinonasal inverted papilloma.. Rhinology, 2006, 44 (3), pp.211-5. ⟨inserm-04145287⟩
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