Characterization of cell-fate decision landscapes by estimating transcription factor dynamics

Highlights d FateCompass is an integrative pipeline to estimate TF activity dynamics d FateCompass learns trajectories using RNA velocity or a differentiation potential d FateCompass reveals known and novel regulators in pancreatic datasets d Lineage tracing validates FateCompass predictions for in vitro b cell differentiation

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Life Sciences [q-bio]

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Gérard Gradwohl : Connect in order to contact the contributor

https://inserm.hal.science/inserm-04140681

Submitted on : Monday, June 26, 2023-9:01:35 AM

Last modification on : Thursday, August 29, 2024-11:46:04 AM

Long-term archiving on: Wednesday, September 27, 2023-6:12:26 PM

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inserm-04140681 , version 1 (26-06-2023)

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HAL Id : inserm-04140681 , version 1
DOI : 10.1016/j.crmeth.2023.100512

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Sara Jiménez, Valérie Schreiber, Reuben Mercier, Gérard Gradwohl, Nacho Molina. Characterization of cell-fate decision landscapes by estimating transcription factor dynamics. Cell Reports Methods, 2023, pp.100512. ⟨10.1016/j.crmeth.2023.100512⟩. ⟨inserm-04140681⟩

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