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Article Dans Une Revue Frontiers in Immunology Année : 2021

Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients

Andrew D Griffiths
Lionel K Tan
  • Fonction : Auteur

Résumé

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The immune system plays a key role in sepsis onset and remains dysregulated over time in a heterogeneous manner. Here, we decipher the heterogeneity of the first week evolution of the monocyte HLA-DR (mHLA-DR) surface protein expression in septic patients, a key molecule for adaptive immunity onset. We found and verified four distinctive trajectories endotypes in a discovery (n = 276) and a verification cohort (n = 102). We highlight that 59% of septic patients exhibit low or decreasing mHLA-DR expression while in others mHLA-DR expression increased. This study depicts the first week behavior of mHLA-DR over time after sepsis onset and shows that initial and third day mHLA-DR expression measurements is sufficient for an early risk stratification of sepsis patients. These patients might benefit from immunomodulatory treatment to improve outcomes. Going further, our study introduces a way of deciphering heterogeneity of immune system after sepsis onset which is a first step to reach a more comprehensive landscape of sepsis.
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Dates et versions

inserm-04030603 , version 1 (15-03-2023)

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Maxime Bodinier, Estelle Peronnet, Karen Brengel-Pesce, Filippo Conti, Thomas Rimmelé, et al.. Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients. Frontiers in Immunology, 2021, 12, pp.795052. ⟨10.3389/fimmu.2021.795052⟩. ⟨inserm-04030603⟩
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