%0 Journal Article %T Nivolumab and interferon-γ rescue therapy to control mixed mould and bacterial superinfection after necrotizing fasciitis and septic shock %+ Physiopathologie de l'immunodépression associée aux réponses inflammatoires systémiques / Pathophysiology of Injury-induced Immunosuppression (PI3) %+ Hôpital Edouard Herriot [CHU - HCL] %+ Centre International de Recherche en Infectiologie (CIRI) %+ Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL] %+ Centre de Traitement des Brûlés [Hôpital E. Herriot - CHU - HCL] (CTB) %A Lukaszewicz, Anne-Claire %A Venet, Fabienne %A Boibieux, André %A Lherm, Mathilde %A Devigne, Bertrand %A Monneret, Guillaume %@ 2211-7539 %J Medical Mycology Case Reports %I [Amsterdam] : Elsevier %V 37 %P 19-22 %8 2022-09 %D 2022 %R 10.1016/j.mmcr.2022.06.003 %M 35770129 %Z Life Sciences [q-bio]Journal articles %X Immunosuppression is a major feature of septic shock and patients are at increased risk for opportunistic infections. We describe a successful use of immunostimulation to treat mixed mould and bacterial superinfection in a previously healthy 38-year-old female patient admitted for severe extensive fasciitis. Interferon gamma associated with nivolumab reversed successfully deactivation of immune cells assessed by altered expressions of monocyte human leukocyte antigen-DR (HLA-DR) and lymphocyte programmed death receptor-1 (PD-1). Immunosuppressed patients in ICU with invasive bacterial and fungal infections may benefit from immunostimulation. %G English %2 https://inserm.hal.science/inserm-04010258/document %2 https://inserm.hal.science/inserm-04010258/file/1-s2.0-S2211753922000252-main.pdf %L inserm-04010258 %U https://inserm.hal.science/inserm-04010258 %~ INSERM %~ UNIV-ST-ETIENNE %~ ENS-LYON %~ HCL %~ CNRS %~ UNIV-LYON1 %~ HEH %~ CIRI %~ UDL %~ UNIV-LYON