%0 Journal Article %T The Pattern of RNA Editing Changes in Pleural Mesothelioma upon Epithelial-Mesenchymal Transition %+ University hospital of Zurich [Zurich] %+ Functional Genomics Center Zurich %+ Universität Zürich [Zürich] = University of Zurich (UZH) %+ Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)) %A Felley-Bosco, Emanuela %A Qi, Weihong %A Jean, Didier %A Meiller, Clément %A Rehrauer, Hubert %Z This research was funded by the Swiss National Science Foundation, grant 320030_182690, Walter-Bruckerhoff Stiftung and Stiftung für Angewandte Krebsforchung; D.J. is supported by Inserm, the Ligue Contre le Cancer (Ile de France committee), the Chancellerie des Universités de Paris (Legs POIX), and Cancéropôle Île-de-France (Emergence). %< avec comité de lecture %@ 1661-6596 %J International Journal of Molecular Sciences %I MDPI %V 24 %N 3 %P 2874 %8 2023-02 %D 2023 %R 10.3390/ijms24032874 %M 36769192 %K RNA editing %K epithelial-to-mesenchymal transition %K pleural mesothelioma. %Z Life Sciences [q-bio]Journal articles %X Pleural mesothelioma (PM) is a cancer where epithelioid, biphasic and sarcomatoid histotypes are observed. Sarcomatoid PM is characterized by mesenchymal features. Multi-omics have been used to characterize the epithelial-to-mesenchymal (EMT) phenotype at the molecular level. We contribute to this effort by including the analysis of RNA editing. We extracted samples with the highest vs. lowest Epithelial score from two PM cohorts and observed increased RNA editing in introns and decreased RNA editing in 3′UTR upon EMT. The same was observed in primary PM primary cultures stratified by transcriptomics analysis into two groups, one of them enriched with mesenchymal features. Our data demonstrate that, as has been observed in other cancer types, RNA editing associates to EMT phenotype in PM. %G English %2 https://inserm.hal.science/inserm-03986912/document %2 https://inserm.hal.science/inserm-03986912/file/ijms-24-02874.pdf %L inserm-03986912 %U https://inserm.hal.science/inserm-03986912 %~ INSERM %~ EPHE %~ CORDELIERS %~ PSL %~ SORBONNE-UNIVERSITE %~ SORBONNE-UNIV %~ SU-SCIENCES %~ TEST-DEV %~ UNIV-PARIS %~ UNIVERSITE-PARIS %~ UP-SANTE %~ EPHE-PSL %~ SU-TI %~ ALLIANCE-SU