Quadruplexes Are Everywhere…On the Other Strand Too: The i-Motif - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Chapitre D'ouvrage Année : 2022

Quadruplexes Are Everywhere…On the Other Strand Too: The i-Motif

Résumé

i-Motif (the name stems from “intercalated”), also known as i-DNA, is a pH-dependent four-stranded nucleic acid structure formed by cytosine-rich sequences via hemi-protonated and intercalated CC+ base pairs. Although this structure is favored at acidic pH, recent evidence has demonstrated its existence in vivo, stimulating the exploration of its biological roles. Before that, it was mostly regarded as a mere structural oddity, or a tool for bio- and nanotechnol- ogies: its unique pH-sensitive nature makes it a remarkable candidate as a nanodevice and pH sensor. In this chapter, we provide a general panorama of this structure. The history and basic knowledge of i-motif are provided first. Then, we present the main characterization methods of i-motif and factors affecting i-motif stability. Following that, we focus on the applications of i-motif in nanotechnology and analytical chemistry. Last, the interaction between i-motif and ligands and the physiological roles of i-motif are briefly introduced. We argue that the i-motif, similar to its complementary G-quadruplex, is an attractive structure for multidisciplinary approaches. It serves as a basic component for various applications and has been proposed to play biological roles in vivo.

Mots clés

Fichier non déposé

Dates et versions

inserm-03950168 , version 1 (21-01-2023)

Identifiants

Citer

Jean-Louis Mergny, Mingpan Cheng, Jun Zhou. Quadruplexes Are Everywhere…On the Other Strand Too: The i-Motif. Handbook of Chemical Biology of Nucleic Acids, Springer Nature Singapore, pp.1-25, 2022, ⟨10.1007/978-981-16-1313-5_5-1⟩. ⟨inserm-03950168⟩
19 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More