Cochlin Produced by Follicular Dendritic Cells Promotes Antibacterial Innate Immunity - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Immunity Year : 2013

Cochlin Produced by Follicular Dendritic Cells Promotes Antibacterial Innate Immunity

Abstract

Cochlin, an extracellular matrix protein, shares homologies with the Factor C, a serine protease found in horseshoe crabs, which is critical for antibacterial responses. Mutations in the COCH gene are responsible for human DFNA9 syndrome, a disorder characterized by neurodegeneration of the inner ear that leads to hearing loss and vestibular impairments. The physiological function of cochlin, however, is unknown. Here, we report that cochlin is specifically expressed by follicular dendritic cells and selectively localized in the fine extracellular network of conduits in the spleen and lymph nodes. During inflammation, cochlin was cleaved by aggrecanases and secreted into blood circulation. In models of lung infection with Pseudomonas aeruginosa and Staphylococcus aureus, Coch(-/-) mice show reduced survival linked to defects in local cytokine production, recruitment of immune effector cells, and bacterial clearance. By producing cochlin, FDCs thus contribute to the innate immune response in defense against bacteria.
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Dates and versions

inserm-03930781 , version 1 (09-01-2023)

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Bénédicte F. Py, Santiago F. Gonzalez, Kai Long, Mi-Sung Kim, Young-A. Kim, et al.. Cochlin Produced by Follicular Dendritic Cells Promotes Antibacterial Innate Immunity. Immunity, 2013, 38 (5), pp.1063-1072. ⟨10.1016/j.immuni.2013.01.015⟩. ⟨inserm-03930781⟩

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