%0 Journal Article %T Morphine and metabolites plasma levels after administration of sustained release morphine in Roux-en-Y gastric bypass subjects versus matched control subjects %+ Variabilité de réponse aux Psychotropes (VariaPsy - U1144) %+ Hôpital Cochin [AP-HP] %+ Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN) %+ Nutrition et obésités: approches systémiques (UMR-S 1269) (Nutriomics) %+ Hôpital Lariboisière-Fernand-Widal [APHP] %A Hachon, Lorry %A Reis, Rafael %A Labat, Laurence %A Poitou, Christine %A Jacob, Aude %A Declèves, Xavier %A Lloret-Linares, Celia %< avec comité de lecture %@ 1550-7289 %J Surgery for Obesity and Related Diseases %I Elsevier %V 13 %N 11 %P 1869-1874 %8 2017-11 %D 2017 %R 10.1016/j.soard.2017.07.030 %M 28864105 %K Bariatric surgery %K Glucuronides %K Metabolic ratio %K Morphine %K Obesity %K Opioids %K Pain. %Z Life Sciences [q-bio]Journal articles %X Background: Better knowledge of opioid pharmacology after Roux-en-Y gastric bypass (RYGB) is required for optimizing their use in this growing population.Objective: The aim of this case-controlled pharmacokinetic (PK) study was to compare morphine and its glucuronidated metabolites (morphine-3-glucuronide and morphine-6-glucuronide) plasma PKs between patients with RYGB and their controls.Settings: University hospital, Lariboisière Hospital, Paris.Methods: Thirty milligrams of morphine as a sustained-release formulation was orally administered in 12 women who had undergone RYGB for at least 2 years (RYGB group) and in their nonsurgical controls matched for sex, body mass index (±2 points), and age (±5 yr). Morphine, morphine-3-glucuronide, and morphine-6-glucuronide plasma concentrations over a 12-hour period were determined by a validated method using liquid chromatography mass spectrometry in tandem. Drowsiness, respiratory rate, and oxygen saturation were monitored during the PK visit.Results: Morphine oral area under the curve (for time 0-12 hr; 115.8 ± 108.0 nmol.hr/L and 86.9 ± 38.8 nmol.hr/L for RYGB group and control group, respectively, P = .71), morphine at maximal concentration, metabolites oral area under the curve (for time 0-12 hr), and other PK parameters were similar between groups. After drug administration, mean drowsiness was superior in RYGB group. Mean respiratory rate and oxygen saturation were similar in both groups.Conclusion: No dose adjustment seems to be needed for sustained release morphine when prescribed to RYGB patients. %G English %L inserm-03823148 %U https://inserm.hal.science/inserm-03823148 %~ INSERM %~ UNIV-PARIS5 %~ UNIV-PARIS7 %~ UPMC %~ APHP %~ ICAN %~ USPC %~ UPMC_POLE_4 %~ SORBONNE-UNIVERSITE %~ SU-INF-2018 %~ SU-MEDECINE %~ SU-MED %~ UNIV-PARIS %~ UP-SANTE %~ ALLIANCE-SU %~ NUTRIOMICS