Current HLA Investigations on SARS-CoV-2 and Perspectives - Inserm - Institut national de la santé et de la recherche médicale
Article Dans Une Revue Frontiers in Genetics Année : 2021

Current HLA Investigations on SARS-CoV-2 and Perspectives

Résumé

The rapid, global spread of the SARS-CoV-2 virus during the current pandemic has triggered numerous efforts in clinical and research settings to better understand the host genetics' interactions and the severity of COVID-19. Due to the established major role played by MHC/HLA polymorphism in infectious disease course and susceptibility, immunologists and geneticists have teamed up to investigate its contribution to the SARS-CoV-2 infection and COVID-19 progression. A major goal of the Covid-19|HLA & Immunogenetics Consortium is to support and unify these efforts. Here, we present a review of HLA immunogenomics studies in the SARS-CoV-2 pandemic and reflect on the role of various HLA data, their limitation and future perspectives.
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Dates et versions

inserm-03627433 , version 1 (01-04-2022)

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Venceslas Douillard, Erick Castelli, Steven Mack, Jill Hollenbach, Pierre-Antoine Gourraud, et al.. Current HLA Investigations on SARS-CoV-2 and Perspectives. Frontiers in Genetics, 2021, 12, pp.774922. ⟨10.3389/fgene.2021.774922⟩. ⟨inserm-03627433⟩
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