Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination
Christopher G Jacob
(1)
,
Nguyen Thuy-Nhien
(2)
,
Mayfong Mayxay
(3, 4, 5)
,
Richard J Maude
(5, 6, 7)
,
Huynh Hong Quang
(8)
,
Bouasy Hongvanthong
(9)
,
Viengxay Vanisaveth
(9)
,
Thang Ngo Duc
(10)
,
Huy Rekol
(11)
,
Rob van Der Pluijm
(5, 6)
,
Lorenz von Seidlein
(5, 6)
,
Rick Fairhurst
(12)
,
François Nosten
(5, 13)
,
Md Amir Hossain
(14)
,
Naomi Park
(1)
,
Scott Goodwin
(1)
,
Pascal Ringwald
(15)
,
Keobouphaphone Chindavongsa
(9)
,
Paul Newton
(3, 5, 6)
,
Elizabeth Ashley
(3, 5)
,
Sonexay Phalivong
(3)
,
Rapeephan Maude
(6)
,
Rithea Leang
(11)
,
Cheah Huch
(11)
,
Le Thanh Dong
(16)
,
Kim-Tuyen Nguyen
(2)
,
Tran Minh Nhat
(2)
,
Tran Tinh Hien
(2)
,
Hoa Nguyen
(17)
,
Nicole Zdrojewski
(17)
,
Sara Canavati
(17)
,
Abdullah Abu Sayeed
(14)
,
Didar Uddin
(6)
,
Caroline Buckee
(7)
,
Caterina I Fanello
(5, 6)
,
Marie Onyamboko
(18)
,
Thomas Peto
(5, 6)
,
Rupam Tripura
(5, 6)
,
Chanaki Amaratunga
(12)
,
Aung Myint Thu
(5, 13)
,
Gilles Delmas
(5, 13)
,
Jordi Landier
(13, 19)
,
Daniel M Parker
(13, 20)
,
Nguyen Hoang Chau
(2)
,
Dysoley Lek
(11)
,
Seila Suon
(11)
,
James Callery
(5, 6)
,
Podjanee Jittamala
(6)
,
Borimas Hanboonkunupakarn
(6)
,
Sasithon Pukrittayakamee
(6, 21)
,
Aung Pyae Phyo
(5, 22)
,
Frank Smithuis
(5, 22)
,
Khin Lin
(23)
,
Myo Thant
(24)
,
Tin Maung Hlaing
(24)
,
Parthasarathi Satpathi
(25)
,
Sanghamitra Satpathi
(26)
,
Prativa K Behera
(26)
,
Amar Tripura
(27)
,
Subrata Baidya
(27)
,
Neena Valecha
(28)
,
Anupkumar R Anvikar
(28)
,
Akhter Ul Islam
(29)
,
Abul Faiz
,
Chanon Kunasol
(6)
,
Eleanor Drury
(30)
,
Mihir Kekre
(30)
,
Mozam Ali
(30)
,
Katie Love
(30)
,
Shavanthi Rajatileka
(30)
,
Anna E Jeffreys
(5)
,
Kate Rowlands
(5)
,
Christina S Hubbart
(5)
,
Mehul Dhorda
(5, 6, 31)
,
Ranitha Vongpromek
(6, 31)
,
Namfon Kotanan
(6)
,
Phrutsamon Wongnak
(6)
,
Jacob Almagro Garcia
(5)
,
Richard D Pearson
(30, 5)
,
Cristina V Ariani
(30)
,
Thanat Chookajorn
(6)
,
Cinzia Malangone
(30)
,
T Nguyen
(30)
,
Jim Stalker
(30)
,
Ben Jeffery
(5)
,
Jonathan Keatley
(30)
,
Kimberly J Johnson
(30, 5)
,
Dawn Muddyman
(30)
,
Xin Hui S Chan
(5, 6)
,
John Sillitoe
(30)
,
Roberto Amato
(30)
,
Victoria Simpson
(30, 5)
,
Sonia Gonçalves
(30)
,
Kirk Rockett
(30, 32)
,
Nicholas P Day
(5, 6)
,
Arjen M Dondorp
(5, 6)
,
Dominic P Kwiatkowski
(30, 5)
,
Olivo Miotto
(30, 6, 5)
1
Wellcome Sanger Institute [Hinxton, Royaume-Uni]
2 OUCRU - Oxford University Clinical Research Unit [Ho Chi Minh City]
3 Mahosot Hospital [Vientiane, Laos]
4 Institute of Research and Education Development [Vientiane, Lao People’s Democratic Republic]
5 University of Oxford
6 Mahidol University [Bangkok]
7 Harvard T.H. Chan School of Public Health
8 IMPE - Institute of Malariology, Parasitology, and Entomology [Quy Nhon, Vietnam]
9 CMPE - Centre of Malariology, Parasitology, and Entomology [Vientiane, Lao People’s Democratic Republic]
10 National Institute of Malariology, Parasitology and Entomology [Hanoi]
11 CNM - National Center for Parasitology, Entomology and Malaria Control [Phnom Penh, Cambodia]
12 NIAID-NIH - National Institute of Allergy and Infectious Diseases [Bethesda]
13 SMRU - Shoklo Malaria Research Unit [Mae Sot, Thailand]
14 CMCH - Chittagong Medical College Hospital [Chittagong, Bangladesh]
15 OMS / WHO - Organisation Mondiale de la Santé / World Health Organization Office [Genève, Suisse]
16 IMPE - Institute of Malariology, Parasitology, and Entomology [Ho Chi Minh City, Vietnam]
17 VPI - Vysnova Partners Inc [Hanoi, Vietnam]
18 UNIKIN - University of Kinshasa
19 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
20 UC Irvine - University of California [Irvine]
21 Royal Society of Thailand [Bangkok, Thailand]
22 Myanmar Oxford Clinical Research Unit [Yangon, Myanmar]
23 The Department of Medical Research (Upper Myanmar)
24 DSMRC - Defence Services Medical Research Centre [Naypyitaw, Myanmar]
25 MMC - Midnapore Medical College [Midnapur, India]
26 IGH - ispat general hospital [Rourkela, India]
27 AMC - Agartala Medical College [Agartala, India]
28 NIMR - National Institute of Malaria Research [New Dehli, Inde]
29 RUHC - Ramu Upazila Health Complex [Cox’s Bazar, Bangladesh]
30 The Wellcome Trust Sanger Institute [Cambridge]
31 WWARN - WorldWide Antimalarial Resistance Network [Bangkok]
32 The Wellcome Trust Centre for Human Genetics [Oxford]
2 OUCRU - Oxford University Clinical Research Unit [Ho Chi Minh City]
3 Mahosot Hospital [Vientiane, Laos]
4 Institute of Research and Education Development [Vientiane, Lao People’s Democratic Republic]
5 University of Oxford
6 Mahidol University [Bangkok]
7 Harvard T.H. Chan School of Public Health
8 IMPE - Institute of Malariology, Parasitology, and Entomology [Quy Nhon, Vietnam]
9 CMPE - Centre of Malariology, Parasitology, and Entomology [Vientiane, Lao People’s Democratic Republic]
10 National Institute of Malariology, Parasitology and Entomology [Hanoi]
11 CNM - National Center for Parasitology, Entomology and Malaria Control [Phnom Penh, Cambodia]
12 NIAID-NIH - National Institute of Allergy and Infectious Diseases [Bethesda]
13 SMRU - Shoklo Malaria Research Unit [Mae Sot, Thailand]
14 CMCH - Chittagong Medical College Hospital [Chittagong, Bangladesh]
15 OMS / WHO - Organisation Mondiale de la Santé / World Health Organization Office [Genève, Suisse]
16 IMPE - Institute of Malariology, Parasitology, and Entomology [Ho Chi Minh City, Vietnam]
17 VPI - Vysnova Partners Inc [Hanoi, Vietnam]
18 UNIKIN - University of Kinshasa
19 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
20 UC Irvine - University of California [Irvine]
21 Royal Society of Thailand [Bangkok, Thailand]
22 Myanmar Oxford Clinical Research Unit [Yangon, Myanmar]
23 The Department of Medical Research (Upper Myanmar)
24 DSMRC - Defence Services Medical Research Centre [Naypyitaw, Myanmar]
25 MMC - Midnapore Medical College [Midnapur, India]
26 IGH - ispat general hospital [Rourkela, India]
27 AMC - Agartala Medical College [Agartala, India]
28 NIMR - National Institute of Malaria Research [New Dehli, Inde]
29 RUHC - Ramu Upazila Health Complex [Cox’s Bazar, Bangladesh]
30 The Wellcome Trust Sanger Institute [Cambridge]
31 WWARN - WorldWide Antimalarial Resistance Network [Bangkok]
32 The Wellcome Trust Centre for Human Genetics [Oxford]
Richard J Maude
- Fonction : Auteur
- PersonId : 798341
- ORCID : 0000-0002-5355-0562
Lorenz von Seidlein
- Fonction : Auteur
- PersonId : 800617
- ORCID : 0000-0002-0282-6469
François Nosten
- Fonction : Auteur
- PersonId : 768753
- ORCID : 0000-0002-7951-0745
- IdRef : 084012633
Tran Minh Nhat
- Fonction : Auteur
- PersonId : 816475
- ORCID : 0000-0002-9500-8341
Caroline Buckee
- Fonction : Auteur
- PersonId : 808500
- ORCID : 0000-0002-8386-5899
Jordi Landier
- Fonction : Auteur
- PersonId : 21070
- IdHAL : jordilandier
- ORCID : 0000-0001-8619-9775
- IdRef : 183054644
James Callery
- Fonction : Auteur
- PersonId : 816476
- ORCID : 0000-0002-3218-2166
Podjanee Jittamala
- Fonction : Auteur
- PersonId : 812830
- ORCID : 0000-0002-1020-2760
Frank Smithuis
- Fonction : Auteur
- PersonId : 795243
- ORCID : 0000-0002-4704-9915
Abul Faiz
- Fonction : Auteur
Christina S Hubbart
- Fonction : Auteur
- PersonId : 816477
- ORCID : 0000-0001-9576-9581
Richard D Pearson
- Fonction : Auteur
- PersonId : 793847
- ORCID : 0000-0002-7386-3566
Kirk Rockett
- Fonction : Auteur
- PersonId : 802066
- ORCID : 0000-0002-6369-9299
Nicholas P Day
- Fonction : Auteur
- PersonId : 796732
- ORCID : 0000-0003-2309-1171
Arjen M Dondorp
- Fonction : Auteur
- PersonId : 795244
- ORCID : 0000-0001-5190-2395
Olivo Miotto
- Fonction : Auteur
- PersonId : 770355
- ORCID : 0000-0001-8060-6771
Résumé
Background: National Malaria Control Programmes (NMCPs) currently make limited use of parasite genetic data. We have developed GenRe-Mekong, a platform for genetic surveillance of malaria in the Greater Mekong Subregion (GMS) that enables NMCPs to implement large-scale surveillance projects by integrating simple sample collection procedures in routine public health procedures.
Methods: Samples from symptomatic patients are processed by SpotMalaria, a high-throughput system that produces a comprehensive set of genotypes comprising several drug resistance markers, species markers and a genomic barcode. GenRe-Mekong delivers Genetic Report Cards, a compendium of genotypes and phenotype predictions used to map prevalence of resistance to multiple drugs.
Results: GenRe-Mekong has worked with NMCPs and research projects in eight countries, processing 9623 samples from clinical cases. Monitoring resistance markers has been valuable for tracking the rapid spread of parasites resistant to the dihydroartemisinin-piperaquine combination therapy. In Vietnam and Laos, GenRe-Mekong data have provided novel knowledge about the spread of these resistant strains into previously unaffected provinces, informing decision-making by NMCPs.
Conclusions: GenRe-Mekong provides detailed knowledge about drug resistance at a local level, and facilitates data sharing at a regional level, enabling cross-border resistance monitoring and providing the public health community with valuable insights. The project provides a rich open data resource to benefit the entire malaria community.
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