<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of inserm-03344399</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-21T22:36:53+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Is a treat-to-target approach to lipid-lowering therapy appropriate in patients with chronic kidney disease? A prospective French cohort study</title>
            <author role="aut">
              <persName>
                <forename type="first">Z. A.</forename>
                <surname>Massy</surname>
              </persName>
              <idno type="halauthorid">1150334-0</idno>
              <affiliation ref="#struct-1051097"/>
              <affiliation ref="#struct-253793"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">E.</forename>
                <surname>Kolla</surname>
              </persName>
              <idno type="halauthorid">2284032-0</idno>
              <affiliation ref="#struct-1051097"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">J.</forename>
                <surname>Ferrières</surname>
              </persName>
              <idno type="halauthorid">424102-0</idno>
              <affiliation ref="#struct-101902"/>
              <affiliation ref="#struct-1160981"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">E.</forename>
                <surname>Bruckert</surname>
              </persName>
              <idno type="halauthorid">397570-0</idno>
              <affiliation ref="#struct-1085123"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">O.</forename>
                <surname>Lambert</surname>
              </persName>
              <idno type="halauthorid">207878-0</idno>
              <affiliation ref="#struct-1051097"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">N.</forename>
                <surname>Mansencal</surname>
              </persName>
              <email type="md5">1c8c5fb3b07684e19b02687f866f7037</email>
              <email type="domain">aphp.fr</email>
              <idno type="idhal" notation="numeric">1147925</idno>
              <idno type="halauthorid" notation="string">1002652-1147925</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5500-1535</idno>
              <affiliation ref="#struct-34252"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">M.</forename>
                <surname>Laville</surname>
              </persName>
              <idno type="halauthorid">213588-0</idno>
              <affiliation ref="#struct-1076038"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">L.</forename>
                <surname>Frimat</surname>
              </persName>
              <email type="md5">aa3bbbac6b42f1e1c4605751dddd14ab</email>
              <email type="domain">chu-nancy.fr</email>
              <idno type="idhal" notation="numeric">759372</idno>
              <idno type="halauthorid" notation="string">423705-759372</idno>
              <idno type="IDREF">https://www.idref.fr/113414099</idno>
              <affiliation ref="#struct-1061198"/>
              <affiliation ref="#struct-44280"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">D.</forename>
                <surname>Fouque</surname>
              </persName>
              <idno type="halauthorid">423702-0</idno>
              <affiliation ref="#struct-487467"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">C.</forename>
                <surname>Combe</surname>
              </persName>
              <idno type="halauthorid">321896-0</idno>
              <affiliation ref="#struct-139716"/>
              <affiliation ref="#struct-410000"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">R.</forename>
                <surname>Pecoits-Filho</surname>
              </persName>
              <idno type="halauthorid">2235849-0</idno>
              <affiliation ref="#struct-536211"/>
              <affiliation ref="#struct-444513"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">B.</forename>
                <surname>Stengel</surname>
              </persName>
              <idno type="halauthorid">424397-0</idno>
              <affiliation ref="#struct-1051097"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sophie</forename>
                <surname>Liabeuf</surname>
              </persName>
              <email type="md5">5fd5ff0e6e60130b3a9b7b4e54c5766e</email>
              <email type="domain">u-picardie.fr</email>
              <idno type="idhal" notation="string">sophieliabeuf</idno>
              <idno type="idhal" notation="numeric">750529</idno>
              <idno type="halauthorid" notation="string">55196-750529</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5384-9006</idno>
              <idno type="IDREF">https://www.idref.fr/081054882</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/AFB-7848-2022</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/CAH-7505-2022</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/AFB-7848-2022</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/CAH-7505-2022</idno>
              <affiliation ref="#struct-300535"/>
              <affiliation ref="#struct-533000"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>laboratoire</forename>
                <surname>CarMeN</surname>
              </persName>
              <email type="md5">ad01ffdd0e4524e1bba80c4bac397845</email>
              <email type="domain">inserm.fr</email>
            </editor>
            <funder ref="#projanr-37712"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2021-09-15 08:08:06</date>
              <date type="whenModified">2025-11-25 03:23:48</date>
              <date type="whenReleased">2021-09-16 16:20:21</date>
              <date type="whenProduced">2021-10</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="672787">
                <persName>
                  <forename>laboratoire</forename>
                  <surname>CarMeN</surname>
                </persName>
                <email type="md5">ad01ffdd0e4524e1bba80c4bac397845</email>
                <email type="domain">inserm.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">inserm-03344399</idno>
            <idno type="halUri">https://inserm.hal.science/inserm-03344399</idno>
            <idno type="halBibtex">massy:inserm-03344399</idno>
            <idno type="halRefHtml">&lt;i&gt;Journal of Nephrology&lt;/i&gt;, 2021, 34 (5), pp.1467-1477. &lt;a target="_blank" href="https://dx.doi.org/10.1007/s40620-021-01086-y"&gt;&amp;#x27E8;10.1007/s40620-021-01086-y&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Journal of Nephrology, 2021, 34 (5), pp.1467-1477. &amp;#x27E8;10.1007/s40620-021-01086-y&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="HCL">Hospices Civils de Lyon</idno>
            <idno type="stamp" n="UNIV-TLSE3">Université de Toulouse</idno>
            <idno type="stamp" n="UNIV-PICARDIE">Université de Picardie Jules Verne</idno>
            <idno type="stamp" n="UNIV-LYON1">Université Claude Bernard - Lyon I</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="CARDIO" corresp="INSERM">Cardiovasculaire</idno>
            <idno type="stamp" n="SANTE_PUB_INSERM" corresp="INSERM">Santé Publique à l'Inserm</idno>
            <idno type="stamp" n="CESP" corresp="INSERM">Centre de recherche en Épidémiologie et Santé des Populations</idno>
            <idno type="stamp" n="CHLS" corresp="HCL">Centre Hospitalier Lyon Sud</idno>
            <idno type="stamp" n="ICAN" corresp="SORBONNE-UNIVERSITE">Institut de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition</idno>
            <idno type="stamp" n="UVSQ">Université de Versailles Saint-Quentin-en-Yvelines</idno>
            <idno type="stamp" n="CKD-REIN" corresp="INSERM">Cohorte de patients porteurs d'une maladie rénale chronique</idno>
            <idno type="stamp" n="UNIV-LORRAINE">Université de Lorraine</idno>
            <idno type="stamp" n="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="CARMEN" corresp="INSERM">Cardiovasculaire, Métabolisme, Diabétologie et Nutrition</idno>
            <idno type="stamp" n="APEMAC-UL">APEMAC - Adaptation, mesure et évaluation en santé. Approches interdisciplinaires</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="SORBONNE-UNIV" corresp="SORBONNE-UNIVERSITE">Sorbonne Université 01/01/2018</idno>
            <idno type="stamp" n="SU-MEDECINE" corresp="SORBONNE-UNIVERSITE">Faculté de Santé de Sorbonne Université</idno>
            <idno type="stamp" n="SU-MED" corresp="SORBONNE-UNIVERSITE">Médecine - Sorbonne Université</idno>
            <idno type="stamp" n="UDL">UDL</idno>
            <idno type="stamp" n="BIOTIS" corresp="INSERM">INSERM U1026- The laboratory for the bioengineering of tissues</idno>
            <idno type="stamp" n="UVSQ-UPSACLAY" corresp="UNIV-PARIS-SACLAY">UVSQ-UPSACLAY</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS-SACLAY" corresp="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="GS-SANTE-PUBLIQUE">Graduate School Santé publique</idno>
            <idno type="stamp" n="U-PICARDIE">Université de Picardie Jules Verne</idno>
            <idno type="stamp" n="MP3CV" corresp="U-PICARDIE">Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
            <idno type="stamp" n="UNIV-UT3">Université Toulouse 3</idno>
            <idno type="stamp" n="UT3-INP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="UT3-TOULOUSEINP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="CERPOP">CERPOP</idno>
            <idno type="stamp" n="IHU_ICAN" corresp="SORBONNE-UNIVERSITE">IHU ICAN – Institut de Cardiométabolisme et Nutrition</idno>
            <idno type="stamp" n="CERPOP-VIEILLISSEMENT" corresp="CERPOP">VIEILLISSEMENT</idno>
            <idno type="stamp" n="INSPIIRE-UL">INSPIIRE - Interdisciplinarité en Santé Publique, Interventions &amp; Instruments de mesure complexes – Région Est</idno>
            <idno type="stamp" n="SUPRA_-SVE6">SVE6 - Maladies humaines</idno>
            <idno type="stamp" n="UNIVERSITE-BORDEAUX">Université de Bordeaux</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Is a treat-to-target approach to lipid-lowering therapy appropriate in patients with chronic kidney disease? A prospective French cohort study</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Z. A.</forename>
                    <surname>Massy</surname>
                  </persName>
                  <idno type="halauthorid">1150334-0</idno>
                  <affiliation ref="#struct-1051097"/>
                  <affiliation ref="#struct-253793"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">E.</forename>
                    <surname>Kolla</surname>
                  </persName>
                  <idno type="halauthorid">2284032-0</idno>
                  <affiliation ref="#struct-1051097"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J.</forename>
                    <surname>Ferrières</surname>
                  </persName>
                  <idno type="halauthorid">424102-0</idno>
                  <affiliation ref="#struct-101902"/>
                  <affiliation ref="#struct-1160981"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">E.</forename>
                    <surname>Bruckert</surname>
                  </persName>
                  <idno type="halauthorid">397570-0</idno>
                  <affiliation ref="#struct-1085123"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">O.</forename>
                    <surname>Lambert</surname>
                  </persName>
                  <idno type="halauthorid">207878-0</idno>
                  <affiliation ref="#struct-1051097"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">N.</forename>
                    <surname>Mansencal</surname>
                  </persName>
                  <email type="md5">1c8c5fb3b07684e19b02687f866f7037</email>
                  <email type="domain">aphp.fr</email>
                  <idno type="idhal" notation="numeric">1147925</idno>
                  <idno type="halauthorid" notation="string">1002652-1147925</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5500-1535</idno>
                  <affiliation ref="#struct-34252"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">M.</forename>
                    <surname>Laville</surname>
                  </persName>
                  <idno type="halauthorid">213588-0</idno>
                  <affiliation ref="#struct-1076038"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">L.</forename>
                    <surname>Frimat</surname>
                  </persName>
                  <email type="md5">aa3bbbac6b42f1e1c4605751dddd14ab</email>
                  <email type="domain">chu-nancy.fr</email>
                  <idno type="idhal" notation="numeric">759372</idno>
                  <idno type="halauthorid" notation="string">423705-759372</idno>
                  <idno type="IDREF">https://www.idref.fr/113414099</idno>
                  <affiliation ref="#struct-1061198"/>
                  <affiliation ref="#struct-44280"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">D.</forename>
                    <surname>Fouque</surname>
                  </persName>
                  <idno type="halauthorid">423702-0</idno>
                  <affiliation ref="#struct-487467"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">C.</forename>
                    <surname>Combe</surname>
                  </persName>
                  <idno type="halauthorid">321896-0</idno>
                  <affiliation ref="#struct-139716"/>
                  <affiliation ref="#struct-410000"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">R.</forename>
                    <surname>Pecoits-Filho</surname>
                  </persName>
                  <idno type="halauthorid">2235849-0</idno>
                  <affiliation ref="#struct-536211"/>
                  <affiliation ref="#struct-444513"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">B.</forename>
                    <surname>Stengel</surname>
                  </persName>
                  <idno type="halauthorid">424397-0</idno>
                  <affiliation ref="#struct-1051097"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sophie</forename>
                    <surname>Liabeuf</surname>
                  </persName>
                  <email type="md5">5fd5ff0e6e60130b3a9b7b4e54c5766e</email>
                  <email type="domain">u-picardie.fr</email>
                  <idno type="idhal" notation="string">sophieliabeuf</idno>
                  <idno type="idhal" notation="numeric">750529</idno>
                  <idno type="halauthorid" notation="string">55196-750529</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5384-9006</idno>
                  <idno type="IDREF">https://www.idref.fr/081054882</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/AFB-7848-2022</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/CAH-7505-2022</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/AFB-7848-2022</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/CAH-7505-2022</idno>
                  <affiliation ref="#struct-300535"/>
                  <affiliation ref="#struct-533000"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">21878</idno>
                <idno type="issn">1121-8428</idno>
                <idno type="eissn">1724-6059</idno>
                <title level="j">Journal of Nephrology</title>
                <imprint>
                  <publisher>Italian Society of Nephrology/Springer</publisher>
                  <biblScope unit="volume">34</biblScope>
                  <biblScope unit="issue">5</biblScope>
                  <biblScope unit="pp">1467-1477</biblScope>
                  <date type="datePub">2021-10</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1007/s40620-021-01086-y</idno>
              <idno type="pubmed">34117621</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Cardiovascular disease</term>
                <term xml:lang="en">Chronic kidney disease</term>
                <term xml:lang="en">Lipid-lowering drugs</term>
                <term xml:lang="en">Lipids</term>
                <term xml:lang="en">Low-density lipoprotein cholesterol</term>
              </keywords>
              <classCode scheme="mesh">Aged, 80 and over   Risk Factors</classCode>
              <classCode scheme="mesh">Cardiovascular Diseases/ diagnosis</classCode>
              <classCode scheme="mesh">Prospective Studies</classCode>
              <classCode scheme="mesh">Renal Insufficiency, Chronic/ diagnosis</classCode>
              <classCode scheme="mesh">Renal Insufficiency, Chronic/ epidemiology</classCode>
              <classCode scheme="mesh">Risk Factors</classCode>
              <classCode scheme="mesh">Cardiovascular Diseases/ epidemiology</classCode>
              <classCode scheme="mesh">Cholesterol, LDL</classCode>
              <classCode scheme="mesh">Female</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Hyperlipidemias / prevention &amp; control</classCode>
              <classCode scheme="mesh">Hypolipidemic Agents / therapeutic use</classCode>
              <classCode scheme="mesh">Male</classCode>
              <classCode scheme="mesh">Middle Aged</classCode>
              <classCode scheme="halDomain" n="sdv.sp.pharma">Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology</classCode>
              <classCode scheme="halDomain" n="sdv.mhep.csc">Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system</classCode>
              <classCode scheme="halDomain" n="sdv.spee">Life Sciences [q-bio]/Santé publique et épidémiologie</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Background: Whereas European guidelines recommend adjusting lipid-lowering therapy (LLT) to meet prespecified targets ('treat-to-target') for low-density lipoprotein cholesterol (LDL-C), other guidelines do not ('fire and forget'). In a large observational prospective cohort, we sought to evaluate which strategy could be associated with better cardiovascular outcomes in chronic kidney disease (CKD).Methods: In CKD-REIN, patients (CKD stages 3 and 4) on LLT were categorized according to achievement of LDL-C targets for high and very high cardiovascular risk (&lt; 2.6 and &lt; 1.8 mmol/L, respectively) at baseline. Primary outcome was fatal/non-fatal atheromatous cardiovascular disease (CVD). Secondary outcomes were non-atheromatous CVD, atheromatous or non-atheromatous CVD, and major adverse cardiovascular events.Results: The population comprised 1521 patients (68 ± 12 years, 31% women, mean estimated glomerular filtration rate [eGFR] 35 mL/min/1.73 m2). Overall, 523 (34%) met their LDL-C targets at baseline. Median follow-up was 2.9 years (interquartile range 2.2-3.0). Incidence rates per 100 patient-years were 6.2% (95% confidence interval [CI] 5.5-7.0) for atheromatous CVD, 9.2% (8.3-10.1) for non-atheromatous CVD, 15.2% (14.0-16.4) for atheromatous/non-atheromatous CVD, and 6.3% (5.5-7.1) for major adverse cardiovascular events. Corresponding rates in patients who achieved targets were 6.6%, 9.8%, 16.1%, and 6.3%, respectively. Target achievement was not associated with risk of fatal/non-fatal atheromatous CVD (adjusted hazard ratio 1.04, 95% CI 0.76-1.44, p = 0.77) or fatal/non-fatal atheromatous or non-atheromatous CVD (0.98, 0.78-1.23, p = 0.91).Conclusions: These findings do not appear to support a treat-to-target approach in CKD patients on LLT, and may favor the hypothesis of an advantage of fire-and-forget. Randomized trials are needed to confirm this theory.</p>
            </abstract>
            <particDesc>
              <org type="consortium">CKD-REIN Collaborators</org>
            </particDesc>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1051097" status="VALID">
          <idno type="IdRef">156182254</idno>
          <idno type="ISNI">0000 0004 0638 6872 </idno>
          <idno type="RNSR">201019083D</idno>
          <idno type="ROR">https://ror.org/01ed4t417</idno>
          <orgName>Centre de recherche en épidémiologie et santé des populations</orgName>
          <orgName type="acronym">CESP</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>16 avenue Paul Vaillant Couturier 94807 Villejuif Cedex, France</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="UMR U1018" active="#struct-81173" type="direct"/>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-300153" type="direct"/>
            <relation active="#struct-1066727" type="indirect"/>
            <relation name="U1018" active="#struct-303623" type="direct"/>
            <relation active="#struct-419361" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-253793" status="VALID">
          <orgName>Service Néphrologie/Dialyse [AP-HP Ambroise-Paré]</orgName>
          <desc>
            <address>
              <addrLine>9 Avenue Charles de Gaulle 92100 Boulogne-Billancourt</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-300151" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-101902" status="VALID">
          <orgName>Service Cardiologie [CHU Toulouse]</orgName>
          <desc>
            <address>
              <addrLine>Cardiologie A et B. Pôle Cardiovasculaire et Métabolique, 1, avenue du Professeur Jean Poulhès - TSA 50032 - 31059 Toulouse cedex 9</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-1152891" type="direct"/>
            <relation active="#struct-300075" type="indirect"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-1160981" status="OLD">
          <orgName>Equipe AGING (CERPOP)</orgName>
          <date type="start">2021-01-01</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>37 allées J. Guesde 31000 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://cerpop.inserm.fr/equipe-emergente</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1061597" type="direct"/>
            <relation active="#struct-217752" type="indirect"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation name="UMR1295" active="#struct-303623" type="indirect"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-1085123" status="VALID">
          <orgName>Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière]</orgName>
          <orgName type="acronym">IHU ICAN</orgName>
          <desc>
            <address>
              <addrLine>Hôpital la Pitié Salpêtrière47-83 boulevard de l’Hôpital75013 Paris 13</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://ihuican.org/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-353778" type="direct"/>
            <relation active="#struct-300068" type="indirect"/>
            <relation active="#struct-413221" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-34252" status="VALID">
          <orgName>Service de cardiologie et maladies vasculaires [CHU Ambroise Paré]</orgName>
          <desc>
            <address>
              <addrLine>9, avenue Charles-de-Gaulle 92100 Boulogne-Billancourt</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-300151" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-1076038" status="VALID">
          <orgName>Association pour l'Utilisation du Rein Artificiel Région Lyonnaise</orgName>
          <orgName type="acronym">AURAL</orgName>
          <date type="start">1974-01-01</date>
          <desc>
            <address>
              <addrLine>124 rue Villon, 69008 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.auralyon.org</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1061198" status="OLD">
          <idno type="IdRef">149642849</idno>
          <idno type="ISNI">0000000417641664</idno>
          <idno type="RNSR">200918432A</idno>
          <idno type="IdUnivLorraine">[UL]RNI--</idno>
          <idno type="ROR">https://ror.org/04dx32582</idno>
          <orgName>Adaptation, mesure et évaluation en santé. Approches interdisciplinaires</orgName>
          <orgName type="acronym">APEMAC</orgName>
          <date type="start">2021-01-01</date>
          <date type="end">2023-12-31</date>
          <desc>
            <address>
              <addrLine>Université de Lorraine, Nancy / Metz Devient INSPIIRE le 01/01/2024</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://apemac.univ-lorraine.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UR4360" active="#struct-413289" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-44280" status="VALID">
          <orgName>Service de Néphrologie [CHRU Nancy]</orgName>
          <desc>
            <address>
              <addrLine>rue du Morvan - 54511 Vandoeuvre-les-Nancy Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-nancy.fr/index.htm/page696langfr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300157" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-487467" status="VALID">
          <orgName>Service de Néphrologie [Lyon]</orgName>
          <desc>
            <address>
              <addrLine>Lyon, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-lyon.fr/service-nephrologie-dialyse-nutrition-renale-lyon-sud#toc-activit-de-recherche</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300074" type="direct"/>
            <relation active="#struct-353860" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-139716" status="VALID">
          <idno type="IdRef">184688957</idno>
          <idno type="RNSR">201119376T</idno>
          <orgName>Bioingénierie tissulaire</orgName>
          <orgName type="acronym">BIOTIS</orgName>
          <desc>
            <address>
              <addrLine>146, rue Léo Saignat 33076 Bordeaux cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.biotis-bordeaux.com//</ref>
          </desc>
          <listRelation>
            <relation active="#struct-259761" type="direct"/>
            <relation name="U1026" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="department" xml:id="struct-410000" status="VALID">
          <orgName>Service de Néphrologie-transplantation-dialyse [Bordeaux]</orgName>
          <desc>
            <address>
              <addrLine>pl Amélie Raba Léon33076 BORDEAUX CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-bordeaux.fr/Les-services/Service-de-N%C3%A9phrologie-transplantation-dialyse/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300122" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-536211" status="VALID">
          <idno type="ROR">https://ror.org/043qmbk61</idno>
          <orgName>Arbor Research Collaborative for Health</orgName>
          <desc>
            <address>
              <addrLine>340 E Huron St # 300, Ann Arbor, MI 48104</addrLine>
              <country key="US"/>
            </address>
            <ref type="url">https://www.arborresearch.org/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-444513" status="VALID">
          <idno type="IdRef">139037039</idno>
          <idno type="ISNI">0000000086010541</idno>
          <idno type="ROR">https://ror.org/02x1vjk79</idno>
          <idno type="Wikidata">Q1131088</idno>
          <orgName>Pontifícia Universidade Católica do Paraná [Curitiba, Brasil] = Pontifical Catholic University of Paraná [Curitiba, Brazil] = Université catholique pontificale du Paraná [Curitiba, Brésil]</orgName>
          <orgName type="acronym">PUCPR</orgName>
          <desc>
            <address>
              <addrLine>Rua Imaculada Conceição, 1155 -  Prado Velho -  Cx.Postal 16210 - CEP 81611 970 - Curitiba – PR</addrLine>
              <country key="BR"/>
            </address>
            <ref type="url">http://www.pucpr.br/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300535" status="VALID">
          <orgName>CHU Amiens-Picardie</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-533000" status="VALID">
          <idno type="IdRef">195403800</idno>
          <idno type="RNSR">201220168Z</idno>
          <idno type="ROR">https://ror.org/00bgnvd66</idno>
          <orgName>Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires - UR UPJV 7517</orgName>
          <orgName type="acronym">MP3CV</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Picardie Jules Verne - Centre de Recherche Universitaire en Santé (CURS) - CHU Sud - rue Renée Laennec - 80054 Amiens Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://mp3cv.u-picardie.fr/accueil-mp3cv-422954.kjsp</ref>
          </desc>
          <listRelation>
            <relation name="UR7517" active="#struct-300258" type="direct"/>
            <relation name="U1088" active="#struct-300535" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-81173" status="VALID">
          <idno type="IdRef">03082057X</idno>
          <idno type="ISNI">0000 0001 2323 0229 </idno>
          <idno type="ROR">https://ror.org/03mkjjy25</idno>
          <orgName>Université de Versailles Saint-Quentin-en-Yvelines</orgName>
          <orgName type="acronym">UVSQ</orgName>
          <date type="start">1991-07-22</date>
          <desc>
            <address>
              <addrLine>55 avenue de Paris - 78035 Versailles cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.uvsq.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300153" status="VALID">
          <idno type="ROR">https://ror.org/05n7yzd13</idno>
          <orgName>Hôpital Paul Brousse</orgName>
          <desc>
            <address>
              <addrLine>12 Avenue Paul Vaillant Couturier, 94800 Villejuif</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-1066727" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-1066727" status="VALID">
          <orgName>AP-HP. Université Paris Saclay</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.aphp.fr/groupes-hospitaliers-de-lap-hp</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-419361" status="VALID">
          <idno type="IdRef">241345251</idno>
          <idno type="ROR">https://ror.org/03xjwb503</idno>
          <orgName>Université Paris-Saclay</orgName>
          <desc>
            <address>
              <addrLine>Bâtiment Bréguet, 3 Rue Joliot Curie 2e ét, 91190 Gif-sur-Yvette</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-paris-saclay.fr/fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300151" status="VALID">
          <idno type="ROR">https://ror.org/03j6rvb05</idno>
          <orgName>Hôpital Ambroise Paré [AP-HP]</orgName>
          <desc>
            <address>
              <addrLine>9, avenue Charles de Gaulle92104 Boulogne-Billancourt cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-1152891" status="VALID">
          <orgName>Pôle Cardiovasculaire et Métabolique [CHU Toulouse]</orgName>
          <desc>
            <address>
              <addrLine>Toulouse</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300075" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300075" status="VALID">
          <orgName>Centre Hospitalier Universitaire de Toulouse</orgName>
          <orgName type="acronym">CHU Toulouse</orgName>
          <desc>
            <address>
              <addrLine>regroupe les hôpitaux  Purpan, Rangueil, Pierre-Paul Riquet, Larey, Paule de Viguier, Hôtel Dieu Saint-Jacques, La Grave, etc.</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-toulouse.fr</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1061597" status="OLD">
          <idno type="IdRef">252835271</idno>
          <orgName>Centre d'Epidémiologie et de Recherche en santé des POPulations</orgName>
          <orgName type="acronym">CERPOP</orgName>
          <date type="start">2021-01-01</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>37 allées J. Guesde 31000 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.u1027.inserm.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-217752" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation name="UMR1295" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-217752" status="OLD">
          <idno type="IdRef">026404672</idno>
          <idno type="ISNI">0000000121617331</idno>
          <idno type="ROR">https://ror.org/02v6kpv12</idno>
          <idno type="Wikidata">Q1273188</idno>
          <orgName>Université Toulouse III - Paul Sabatier</orgName>
          <orgName type="acronym">UT3</orgName>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-tlse3.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-443875" status="VALID">
          <idno type="ROR">https://ror.org/017tgbk05</idno>
          <orgName>Communauté d'universités et établissements de Toulouse</orgName>
          <orgName type="acronym">Comue de Toulouse</orgName>
          <desc>
            <address>
              <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-toulouse.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-353778" status="VALID">
          <idno type="ROR">https://ror.org/02mh9a093</idno>
          <orgName>CHU Pitié-Salpêtrière [AP-HP]</orgName>
          <desc>
            <address>
              <addrLine>47-83 Boulevard de l'Hôpital, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.aphp.fr/contenu/hopital-universitaire-pitie-salpetriere-0</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-413221" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-413221" status="VALID">
          <idno type="IdRef">221333754</idno>
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Sorbonne Université</orgName>
          <orgName type="acronym">SU</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-universite.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-413289" status="VALID">
          <idno type="IdRef">157040569</idno>
          <idno type="IdUnivLorraine">[UL]100--</idno>
          <idno type="ROR">https://ror.org/04vfs2w97</idno>
          <orgName>Université de Lorraine</orgName>
          <orgName type="acronym">UL</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-lorraine.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300157" status="VALID">
          <orgName>Centre Hospitalier Régional Universitaire de Nancy</orgName>
          <orgName type="acronym">CHRU Nancy</orgName>
          <desc>
            <address>
              <addrLine>Siège social : 29 avenue du Maréchal de Lattre de Tassigny, CO 60034, 54035 NANCY CEDEXHôpital Central : 29 Avenue du Maréchal de Lattre de Tassigny, 54035 NancyHôpitaux de Brabois / Enfants : Rue du Morvan, 54500 Vandœuvre-lès-NancyMaternité régionale :10 Avenue Dr Heydenreich, 54000 Nancy</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-nancy.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300074" status="VALID">
          <idno type="IdRef">026534657</idno>
          <idno type="ROR">https://ror.org/01502ca60</idno>
          <orgName>Hospices Civils de Lyon</orgName>
          <orgName type="acronym">HCL</orgName>
          <desc>
            <address>
              <addrLine>3 Quai des Célestins69002 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/hospices-civils-de-lyon-hcl</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-353860" status="VALID">
          <idno type="ROR">https://ror.org/023xgd207</idno>
          <orgName>Centre Hospitalier Lyon Sud [CHU - HCL]</orgName>
          <orgName type="acronym">CHLS</orgName>
          <desc>
            <address>
              <addrLine>165 Chemin du Grand Revoyet69495 Pierre-Bénite</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/centre-hospitalier-lyon-sud</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300074" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-259761" status="VALID">
          <idno type="IdRef">175206562</idno>
          <idno type="ROR">https://ror.org/057qpr032</idno>
          <orgName>Université de Bordeaux</orgName>
          <orgName type="acronym">UB</orgName>
          <desc>
            <address>
              <addrLine>35, place Pey Berland - 33076 Bordeaux</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.u-bordeaux.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300122" status="VALID">
          <idno type="IdRef">028228421</idno>
          <idno type="ROR">https://ror.org/01hq89f96</idno>
          <orgName>Centre Hospitalier Universitaire de Bordeaux</orgName>
          <orgName type="acronym">CHU Bordeaux</orgName>
          <desc>
            <address>
              <addrLine>12 rue Dubernat 33400 Talence</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-bordeaux.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300258" status="VALID">
          <idno type="IdRef">026403714</idno>
          <idno type="ISNI">0000 0001 0789 1385</idno>
          <idno type="ROR">https://ror.org/01gyxrk03</idno>
          <orgName>Université de Picardie Jules Verne</orgName>
          <orgName type="acronym">UPJV</orgName>
          <desc>
            <address>
              <addrLine>Chemin du Thil - 80000 Amiens</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.u-picardie.fr/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-37712" status="VALID">
          <idno type="anr">ANR-10-COHO-0001</idno>
          <idno type="program">Cohortes</idno>
          <orgName>CKD-REIN</orgName>
          <desc>Maladie Rénale Chronique - Réseau Epidémiologie et Information en Néphrologie</desc>
          <date type="start">2010</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>