<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of inserm-03328429</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-22T10:41:04+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Water intake and progression of chronic kidney disease: the CKD-REIN cohort study</title>
            <author role="aut">
              <persName>
                <forename type="first">S.</forename>
                <surname>Wagner</surname>
              </persName>
              <email type="md5">2979fa842ed7cb140f5304610844ab2d</email>
              <email type="domain">chru-nancy.fr</email>
              <idno type="idhal" notation="numeric">1380981</idno>
              <idno type="halauthorid" notation="string">62830-1380981</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3251-3754</idno>
              <affiliation ref="#struct-254924"/>
              <affiliation ref="#struct-223006"/>
              <affiliation ref="#struct-506806"/>
              <affiliation ref="#struct-443031"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">T.</forename>
                <surname>Merkling</surname>
              </persName>
              <email type="md5">77fbdb0e15bb20cb276d39bc3f479180</email>
              <email type="domain">gmail.com</email>
              <idno type="idhal" notation="numeric">1006019</idno>
              <idno type="halauthorid" notation="string">2272312-1006019</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5878-0359</idno>
              <idno type="IDREF">https://www.idref.fr/180467409</idno>
              <affiliation ref="#struct-254924"/>
              <affiliation ref="#struct-223006"/>
              <affiliation ref="#struct-506806"/>
              <affiliation ref="#struct-443031"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">M.</forename>
                <surname>Metzger</surname>
              </persName>
              <idno type="halauthorid">265083-0</idno>
              <affiliation ref="#struct-1051097"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">L.</forename>
                <surname>Bankir</surname>
              </persName>
              <idno type="halauthorid">192120-0</idno>
              <affiliation ref="#struct-1004777"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">M.</forename>
                <surname>Laville</surname>
              </persName>
              <idno type="halauthorid">213588-0</idno>
              <affiliation ref="#struct-1062221"/>
              <affiliation ref="#struct-353860"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">L.</forename>
                <surname>Frimat</surname>
              </persName>
              <email type="md5">aa3bbbac6b42f1e1c4605751dddd14ab</email>
              <email type="domain">chu-nancy.fr</email>
              <idno type="idhal" notation="numeric">759372</idno>
              <idno type="halauthorid" notation="string">423705-759372</idno>
              <idno type="IDREF">https://www.idref.fr/113414099</idno>
              <affiliation ref="#struct-44280"/>
              <affiliation ref="#struct-1061198"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">C.</forename>
                <surname>Combe</surname>
              </persName>
              <idno type="halauthorid">321896-0</idno>
              <affiliation ref="#struct-410000"/>
              <affiliation ref="#struct-139716"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">C.</forename>
                <surname>Jacquelinet</surname>
              </persName>
              <idno type="halauthorid">489890-0</idno>
              <affiliation ref="#struct-81173"/>
              <affiliation ref="#struct-115378"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">D.</forename>
                <surname>Fouque</surname>
              </persName>
              <idno type="halauthorid">423702-0</idno>
              <affiliation ref="#struct-1062221"/>
              <affiliation ref="#struct-353860"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Z. A.</forename>
                <surname>Massy</surname>
              </persName>
              <idno type="halauthorid">1150334-0</idno>
              <affiliation ref="#struct-253793"/>
              <affiliation ref="#struct-1051097"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">B.</forename>
                <surname>Stengel</surname>
              </persName>
              <idno type="halauthorid">424397-0</idno>
              <affiliation ref="#struct-81173"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>laboratoire</forename>
                <surname>CarMeN</surname>
              </persName>
              <email type="md5">ad01ffdd0e4524e1bba80c4bac397845</email>
              <email type="domain">inserm.fr</email>
            </editor>
            <funder ref="#projanr-37712"/>
            <funder>The CKD-REIN study is funded by the Agence Nationale de la Recherche through the 2010 Cohortes-Investissements d’Avenir programme and by the 2010 national Programme Hospitalier de Recherche Clinique</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2021-08-30 09:21:49</date>
              <date type="whenModified">2026-05-22 10:34:02</date>
              <date type="whenReleased">2021-08-30 15:07:58</date>
              <date type="whenProduced">2021</date>
              <date type="whenEndEmbargoed">9999-12-31</date>
              <ref type="file" target="https://inserm.hal.science/inserm-03328429v1/document">
                <date notBefore="9999-12-31"/>
              </ref>
              <ref type="file" n="1" target="https://inserm.hal.science/inserm-03328429v1/file/gfab036.pdf" id="file-3328429-2919958">
                <date notBefore="9999-12-31"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="672787">
                <persName>
                  <forename>laboratoire</forename>
                  <surname>CarMeN</surname>
                </persName>
                <email type="md5">ad01ffdd0e4524e1bba80c4bac397845</email>
                <email type="domain">inserm.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">inserm-03328429</idno>
            <idno type="halUri">https://inserm.hal.science/inserm-03328429</idno>
            <idno type="halBibtex">wagner:inserm-03328429</idno>
            <idno type="halRefHtml">&lt;i&gt;Nephrology Dialysis Transplantation&lt;/i&gt;, 2021, pp.gfab036. &lt;a target="_blank" href="https://dx.doi.org/10.1093/ndt/gfab036"&gt;&amp;#x27E8;10.1093/ndt/gfab036&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Nephrology Dialysis Transplantation, 2021, pp.gfab036. &amp;#x27E8;10.1093/ndt/gfab036&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by-nc-nd/4.0/">CC BY-NC-ND 4.0 - Attribution - Non-commercial use - No Derivative Works<ref corresp="#file-3328429-2919958"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="HCL">Hospices Civils de Lyon</idno>
            <idno type="stamp" n="EPHE">École Pratique des Hautes Études</idno>
            <idno type="stamp" n="UNIV-LYON1">Université Claude Bernard - Lyon I</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="CESP" corresp="INSERM">Centre de recherche en Épidémiologie et Santé des Populations</idno>
            <idno type="stamp" n="CHLS" corresp="HCL">Centre Hospitalier Lyon Sud</idno>
            <idno type="stamp" n="CORDELIERS" corresp="SORBONNE-UNIVERSITE">Centre de recherche des Cordeliers</idno>
            <idno type="stamp" n="UVSQ">Université de Versailles Saint-Quentin-en-Yvelines</idno>
            <idno type="stamp" n="CKD-REIN" corresp="INSERM">Cohorte de patients porteurs d'une maladie rénale chronique</idno>
            <idno type="stamp" n="UNIV-LORRAINE">Université de Lorraine</idno>
            <idno type="stamp" n="PSL">Université Paris sciences et lettres</idno>
            <idno type="stamp" n="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="DCAC-UL">DCAC - Défaillance Cardiovasculaire Aiguë et Chronique</idno>
            <idno type="stamp" n="CARMEN" corresp="INSERM">Cardiovasculaire, Métabolisme, Diabétologie et Nutrition</idno>
            <idno type="stamp" n="APEMAC-UL">APEMAC - Adaptation, mesure et évaluation en santé. Approches interdisciplinaires</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="SORBONNE-UNIV" corresp="SORBONNE-UNIVERSITE">Sorbonne Université 01/01/2018</idno>
            <idno type="stamp" n="SU-SCIENCES" corresp="SORBONNE-UNIVERSITE">Faculté des Sciences de Sorbonne Université</idno>
            <idno type="stamp" n="TEST-DEV">TEST-DEV</idno>
            <idno type="stamp" n="UDL">UDL</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS" corresp="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UP-SANTE">Université Paris Cité - Faculté de Santé</idno>
            <idno type="stamp" n="BIOTIS" corresp="INSERM">INSERM U1026- The laboratory for the bioengineering of tissues</idno>
            <idno type="stamp" n="EPHE-PSL" corresp="PSL">École Pratique des Hautes Études - PSL</idno>
            <idno type="stamp" n="UVSQ-UPSACLAY" corresp="UNIV-PARIS-SACLAY">UVSQ-UPSACLAY</idno>
            <idno type="stamp" n="UNIVERSITE-PARIS-SACLAY" corresp="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="BMS-UL">Pôle scientifique Biologie, Médecine, Santé de l'Université de Lorraine</idno>
            <idno type="stamp" n="SU-TI">Sorbonne Université - Texte Intégral</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="GS-SANTE-PUBLIQUE">Graduate School Santé publique</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
            <idno type="stamp" n="TEST3-HALCNRS">TEST3-HALCNRS</idno>
            <idno type="stamp" n="RESEAU-EAU">Réseau "Systèmes Agricoles et Eau"</idno>
            <idno type="stamp" n="INSPIIRE-UL">INSPIIRE - Interdisciplinarité en Santé Publique, Interventions &amp; Instruments de mesure complexes – Région Est</idno>
            <idno type="stamp" n="SUPRA_BIOLOGIE">Biologie hors MNHN &amp; stations</idno>
            <idno type="stamp" n="UNIVERSITE-BORDEAUX">Université de Bordeaux</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Water intake and progression of chronic kidney disease: the CKD-REIN cohort study</title>
                <author role="aut">
                  <persName>
                    <forename type="first">S.</forename>
                    <surname>Wagner</surname>
                  </persName>
                  <email type="md5">2979fa842ed7cb140f5304610844ab2d</email>
                  <email type="domain">chru-nancy.fr</email>
                  <idno type="idhal" notation="numeric">1380981</idno>
                  <idno type="halauthorid" notation="string">62830-1380981</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3251-3754</idno>
                  <affiliation ref="#struct-254924"/>
                  <affiliation ref="#struct-223006"/>
                  <affiliation ref="#struct-506806"/>
                  <affiliation ref="#struct-443031"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">T.</forename>
                    <surname>Merkling</surname>
                  </persName>
                  <email type="md5">77fbdb0e15bb20cb276d39bc3f479180</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="numeric">1006019</idno>
                  <idno type="halauthorid" notation="string">2272312-1006019</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5878-0359</idno>
                  <idno type="IDREF">https://www.idref.fr/180467409</idno>
                  <affiliation ref="#struct-254924"/>
                  <affiliation ref="#struct-223006"/>
                  <affiliation ref="#struct-506806"/>
                  <affiliation ref="#struct-443031"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">M.</forename>
                    <surname>Metzger</surname>
                  </persName>
                  <idno type="halauthorid">265083-0</idno>
                  <affiliation ref="#struct-1051097"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">L.</forename>
                    <surname>Bankir</surname>
                  </persName>
                  <idno type="halauthorid">192120-0</idno>
                  <affiliation ref="#struct-1004777"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">M.</forename>
                    <surname>Laville</surname>
                  </persName>
                  <idno type="halauthorid">213588-0</idno>
                  <affiliation ref="#struct-1062221"/>
                  <affiliation ref="#struct-353860"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">L.</forename>
                    <surname>Frimat</surname>
                  </persName>
                  <email type="md5">aa3bbbac6b42f1e1c4605751dddd14ab</email>
                  <email type="domain">chu-nancy.fr</email>
                  <idno type="idhal" notation="numeric">759372</idno>
                  <idno type="halauthorid" notation="string">423705-759372</idno>
                  <idno type="IDREF">https://www.idref.fr/113414099</idno>
                  <affiliation ref="#struct-44280"/>
                  <affiliation ref="#struct-1061198"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">C.</forename>
                    <surname>Combe</surname>
                  </persName>
                  <idno type="halauthorid">321896-0</idno>
                  <affiliation ref="#struct-410000"/>
                  <affiliation ref="#struct-139716"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">C.</forename>
                    <surname>Jacquelinet</surname>
                  </persName>
                  <idno type="halauthorid">489890-0</idno>
                  <affiliation ref="#struct-81173"/>
                  <affiliation ref="#struct-115378"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">D.</forename>
                    <surname>Fouque</surname>
                  </persName>
                  <idno type="halauthorid">423702-0</idno>
                  <affiliation ref="#struct-1062221"/>
                  <affiliation ref="#struct-353860"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Z. A.</forename>
                    <surname>Massy</surname>
                  </persName>
                  <idno type="halauthorid">1150334-0</idno>
                  <affiliation ref="#struct-253793"/>
                  <affiliation ref="#struct-1051097"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">B.</forename>
                    <surname>Stengel</surname>
                  </persName>
                  <idno type="halauthorid">424397-0</idno>
                  <affiliation ref="#struct-81173"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">17345</idno>
                <idno type="issn">0931-0509</idno>
                <idno type="eissn">1460-2385</idno>
                <title level="j">Nephrology Dialysis Transplantation</title>
                <imprint>
                  <publisher>Oxford University Press</publisher>
                  <biblScope unit="pp">gfab036</biblScope>
                  <date type="datePub">2021</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1093/ndt/gfab036</idno>
              <idno type="pubmed">33576809</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">water intake</term>
                <term xml:lang="en">urine volume</term>
                <term xml:lang="en">urine osmolarity</term>
                <term xml:lang="en">kidney function</term>
                <term xml:lang="en">kidney failure</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>BACKGROUND: Optimal daily water intake to prevent chronic kidney disease (CKD) progression is unknown. Taking kidney urine-concentrating ability into account, we studied the relation of kidney outcomes in patients with CKD to total and plain water intake and urine volume. METHODS: Including 1265 CKD patients (median age, 69 years; mean estimated glomerular filtration rate [eGFR], 32 ml/min per 1.73 m2) from the CKD-REIN cohort (2013-2019), we assessed fluid intake at baseline interviews, collected 24-h urine volumes, and estimated urine osmolarity (eUosm). Using Cox and then linear mixed models, we estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for kidney failure and eGFR decline associated with hydration markers, adjusting for CKD progression risk factors and eUosm. RESULTS: Patients' median daily intake was 2.0 (interquartile range: 1.6-2.6) L total water and 1.5 (1-1.7) L plain water; median urine volume was 1.9 (1.6-2.4) L/24 h, and mean eUosm, 374 ± 104 mosm/L. Neither total water intake nor urine volume was associated with either kidney outcome. Kidney failure risk increased significantly with decreasing eUosm below 292 mosm/L. Adjusted HRs for kidney failure associated with plain water intake were 1.88 (95%CI 1.02; 3.47), 1.59 (1.06; 2.38), 1.76 (0.95; 3.24), and 1.55 (1.03; 2.32) in patients drinking \textless0.5, 0.6-1.0, 1.6-2.0, and \textgreater2.0 L/day, compared with those drinking 1.0-1.5 L/day. High plain water intake was also significantly associated with faster eGFR decline. CONCLUSION: In patients with CKD, the relation between plain water intake and progression to kidney failure appears to be U-shaped. Both low and high intake may not be beneficial in CKD.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="regrouplaboratory" xml:id="struct-254924" status="VALID">
          <orgName>Centre d'investigation clinique de Nancy</orgName>
          <orgName type="acronym">CIC 1433</orgName>
          <desc>
            <address>
              <addrLine>4 rue du Morvan - Bâtiment Louis Mathieu - 54500 Vandoeuvre-les-Nancy Cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300157" type="direct"/>
            <relation name="CIC1433" active="#struct-303623" type="direct"/>
            <relation active="#struct-413289" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-223006" status="VALID">
          <idno type="IdRef">181007126</idno>
          <idno type="RNSR">200919207T</idno>
          <idno type="IdUnivLorraine">[UL]RNL--</idno>
          <idno type="ROR">https://ror.org/05ft9wv42</idno>
          <orgName>Défaillance Cardiovasculaire Aiguë et Chronique</orgName>
          <orgName type="acronym">DCAC</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de Médecine - 9 avenue de la Forêt de Haye - BP 184 - 54500 Vandoeuvre les Nancy</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300157" type="direct"/>
            <relation name="U1116" active="#struct-303623" type="direct"/>
            <relation active="#struct-413289" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-506806" status="VALID">
          <orgName>French-Clinical Research Infrastructure Network - F-CRIN [Paris]</orgName>
          <orgName type="acronym">Cardiovascular &amp; Renal Clinical Trialists - CRCT</orgName>
          <desc>
            <address>
              <addrLine>Paris.</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-443031" status="VALID">
          <orgName>Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy]</orgName>
          <orgName type="acronym">INI-CRCT</orgName>
          <desc>
            <address>
              <addrLine>4, rue du Morvan  - 54500 VANDOEUVRE-LES-NANCY-France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inicrct.org/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-303515" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1051097" status="VALID">
          <idno type="IdRef">156182254</idno>
          <idno type="ISNI">0000 0004 0638 6872 </idno>
          <idno type="RNSR">201019083D</idno>
          <idno type="ROR">https://ror.org/01ed4t417</idno>
          <orgName>Centre de recherche en épidémiologie et santé des populations</orgName>
          <orgName type="acronym">CESP</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>16 avenue Paul Vaillant Couturier 94807 Villejuif Cedex, France</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="UMR U1018" active="#struct-81173" type="direct"/>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-300153" type="direct"/>
            <relation active="#struct-1066727" type="indirect"/>
            <relation name="U1018" active="#struct-303623" type="direct"/>
            <relation active="#struct-419361" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1004777" status="VALID">
          <idno type="IdRef">158039203</idno>
          <idno type="ISNI">0000 0004 0620 5824 </idno>
          <idno type="RNSR">200716512X</idno>
          <orgName>Centre de Recherche des Cordeliers</orgName>
          <orgName type="acronym">CRC (UMR_S_1138 / U1138)</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>15 rue de l'Ecole de Médecine - Bâtiment B - 75270 Paris Cedex 06</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.crc.jussieu.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-110691" type="direct"/>
            <relation active="#struct-564132" type="indirect"/>
            <relation name="U1138" active="#struct-303623" type="direct"/>
            <relation active="#struct-413221" type="direct"/>
            <relation name="UMR_S_1138" active="#struct-557826" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1062221" status="VALID">
          <idno type="IdRef">149700210</idno>
          <idno type="ISNI">0000000406205541</idno>
          <idno type="RNSR">201119381Y</idno>
          <orgName>Cardiovasculaire, métabolisme, diabétologie et nutrition</orgName>
          <orgName type="acronym">CarMeN</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de Médecine Lyon Sud - BP 12 - 165 Chemin du Grand Revoyet - 69921 Oullins cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://carmen.univ-lyon1.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UM92" active="#struct-194495" type="direct"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-300074" type="direct"/>
            <relation name="U1060" active="#struct-303623" type="direct"/>
            <relation name="UMR1397" active="#struct-577435" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-353860" status="VALID">
          <idno type="ROR">https://ror.org/023xgd207</idno>
          <orgName>Centre Hospitalier Lyon Sud [CHU - HCL]</orgName>
          <orgName type="acronym">CHLS</orgName>
          <desc>
            <address>
              <addrLine>165 Chemin du Grand Revoyet69495 Pierre-Bénite</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/centre-hospitalier-lyon-sud</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300074" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-44280" status="VALID">
          <orgName>Service de Néphrologie [CHRU Nancy]</orgName>
          <desc>
            <address>
              <addrLine>rue du Morvan - 54511 Vandoeuvre-les-Nancy Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-nancy.fr/index.htm/page696langfr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300157" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1061198" status="OLD">
          <idno type="IdRef">149642849</idno>
          <idno type="ISNI">0000000417641664</idno>
          <idno type="RNSR">200918432A</idno>
          <idno type="IdUnivLorraine">[UL]RNI--</idno>
          <idno type="ROR">https://ror.org/04dx32582</idno>
          <orgName>Adaptation, mesure et évaluation en santé. Approches interdisciplinaires</orgName>
          <orgName type="acronym">APEMAC</orgName>
          <date type="start">2021-01-01</date>
          <date type="end">2023-12-31</date>
          <desc>
            <address>
              <addrLine>Université de Lorraine, Nancy / Metz Devient INSPIIRE le 01/01/2024</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://apemac.univ-lorraine.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UR4360" active="#struct-413289" type="direct"/>
          </listRelation>
        </org>
        <org type="department" xml:id="struct-410000" status="VALID">
          <orgName>Service de Néphrologie-transplantation-dialyse [Bordeaux]</orgName>
          <desc>
            <address>
              <addrLine>pl Amélie Raba Léon33076 BORDEAUX CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-bordeaux.fr/Les-services/Service-de-N%C3%A9phrologie-transplantation-dialyse/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300122" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-139716" status="VALID">
          <idno type="IdRef">184688957</idno>
          <idno type="RNSR">201119376T</idno>
          <orgName>Bioingénierie tissulaire</orgName>
          <orgName type="acronym">BIOTIS</orgName>
          <desc>
            <address>
              <addrLine>146, rue Léo Saignat 33076 Bordeaux cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.biotis-bordeaux.com//</ref>
          </desc>
          <listRelation>
            <relation active="#struct-259761" type="direct"/>
            <relation name="U1026" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-81173" status="VALID">
          <idno type="IdRef">03082057X</idno>
          <idno type="ISNI">0000 0001 2323 0229 </idno>
          <idno type="ROR">https://ror.org/03mkjjy25</idno>
          <orgName>Université de Versailles Saint-Quentin-en-Yvelines</orgName>
          <orgName type="acronym">UVSQ</orgName>
          <date type="start">1991-07-22</date>
          <desc>
            <address>
              <addrLine>55 avenue de Paris - 78035 Versailles cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.uvsq.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-115378" status="VALID">
          <idno type="ROR">https://ror.org/03tajza86</idno>
          <orgName>Agence de la biomédecine [Saint-Denis la Plaine]</orgName>
          <desc>
            <address>
              <addrLine>1 avenue du stade de France93212 SAINT-DENIS LA PLAINE Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.agence-biomedecine.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-253793" status="VALID">
          <orgName>Service Néphrologie/Dialyse [AP-HP Ambroise-Paré]</orgName>
          <desc>
            <address>
              <addrLine>9 Avenue Charles de Gaulle 92100 Boulogne-Billancourt</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-300151" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300157" status="VALID">
          <orgName>Centre Hospitalier Régional Universitaire de Nancy</orgName>
          <orgName type="acronym">CHRU Nancy</orgName>
          <desc>
            <address>
              <addrLine>Siège social : 29 avenue du Maréchal de Lattre de Tassigny, CO 60034, 54035 NANCY CEDEXHôpital Central : 29 Avenue du Maréchal de Lattre de Tassigny, 54035 NancyHôpitaux de Brabois / Enfants : Rue du Morvan, 54500 Vandœuvre-lès-NancyMaternité régionale :10 Avenue Dr Heydenreich, 54000 Nancy</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-nancy.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-413289" status="VALID">
          <idno type="IdRef">157040569</idno>
          <idno type="IdUnivLorraine">[UL]100--</idno>
          <idno type="ROR">https://ror.org/04vfs2w97</idno>
          <orgName>Université de Lorraine</orgName>
          <orgName type="acronym">UL</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-lorraine.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303515" status="VALID">
          <orgName>Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy]</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.reseau-chu.org/article/le-nouvel-institut-lorrain-du-coeur-et-des-vaisseaux-louis-mathieu/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300153" status="VALID">
          <idno type="ROR">https://ror.org/05n7yzd13</idno>
          <orgName>Hôpital Paul Brousse</orgName>
          <desc>
            <address>
              <addrLine>12 Avenue Paul Vaillant Couturier, 94800 Villejuif</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-1066727" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-1066727" status="VALID">
          <orgName>AP-HP. Université Paris Saclay</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.aphp.fr/groupes-hospitaliers-de-lap-hp</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-419361" status="VALID">
          <idno type="IdRef">241345251</idno>
          <idno type="ROR">https://ror.org/03xjwb503</idno>
          <orgName>Université Paris-Saclay</orgName>
          <desc>
            <address>
              <addrLine>Bâtiment Bréguet, 3 Rue Joliot Curie 2e ét, 91190 Gif-sur-Yvette</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-paris-saclay.fr/fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-110691" status="VALID">
          <idno type="IdRef">026375478</idno>
          <idno type="ISNI">0000000121955365</idno>
          <idno type="ROR">https://ror.org/046b3cj80</idno>
          <orgName>École Pratique des Hautes Études</orgName>
          <orgName type="acronym">EPHE</orgName>
          <date type="start">1868-01-01</date>
          <desc>
            <address>
              <addrLine>4-14 Rue Ferrus, 75014 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ephe.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-564132" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-564132" status="VALID">
          <idno type="IdRef">241597595</idno>
          <idno type="ISNI">0000 0004 1784 3645</idno>
          <idno type="ROR">https://ror.org/013cjyk83</idno>
          <orgName>Université Paris Sciences et Lettres</orgName>
          <orgName type="acronym">PSL</orgName>
          <desc>
            <address>
              <addrLine>60 rue Mazarine 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.psl.eu/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-413221" status="VALID">
          <idno type="IdRef">221333754</idno>
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Sorbonne Université</orgName>
          <orgName type="acronym">SU</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-universite.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-557826" status="VALID">
          <idno type="IdRef">236453505</idno>
          <idno type="ISNI">0000 0004 7885 7602</idno>
          <idno type="ROR">https://ror.org/05f82e368</idno>
          <orgName>Université Paris Cité</orgName>
          <orgName type="acronym">UPCité</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>85 boulevard Saint-Germain75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://u-paris.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-194495" status="VALID">
          <idno type="IdRef">026402823</idno>
          <idno type="ISNI">0000000121686185</idno>
          <idno type="ROR">https://ror.org/029brtt94</idno>
          <orgName>Université Claude Bernard Lyon 1</orgName>
          <orgName type="acronym">UCBL</orgName>
          <desc>
            <address>
              <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-lyon1.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301088" status="VALID">
          <idno type="ROR">https://ror.org/01rk35k63</idno>
          <orgName>Université de Lyon</orgName>
          <desc>
            <address>
              <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-lyon.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300074" status="VALID">
          <idno type="IdRef">026534657</idno>
          <idno type="ROR">https://ror.org/01502ca60</idno>
          <orgName>Hospices Civils de Lyon</orgName>
          <orgName type="acronym">HCL</orgName>
          <desc>
            <address>
              <addrLine>3 Quai des Célestins69002 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/hospices-civils-de-lyon-hcl</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-577435" status="VALID">
          <idno type="ROR">https://ror.org/003vg9w96</idno>
          <orgName>Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement</orgName>
          <orgName type="acronym">INRAE</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300122" status="VALID">
          <idno type="IdRef">028228421</idno>
          <idno type="ROR">https://ror.org/01hq89f96</idno>
          <orgName>Centre Hospitalier Universitaire de Bordeaux</orgName>
          <orgName type="acronym">CHU Bordeaux</orgName>
          <desc>
            <address>
              <addrLine>12 rue Dubernat 33400 Talence</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-bordeaux.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-259761" status="VALID">
          <idno type="IdRef">175206562</idno>
          <idno type="ROR">https://ror.org/057qpr032</idno>
          <orgName>Université de Bordeaux</orgName>
          <orgName type="acronym">UB</orgName>
          <desc>
            <address>
              <addrLine>35, place Pey Berland - 33076 Bordeaux</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.u-bordeaux.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300151" status="VALID">
          <idno type="ROR">https://ror.org/03j6rvb05</idno>
          <orgName>Hôpital Ambroise Paré [AP-HP]</orgName>
          <desc>
            <address>
              <addrLine>9, avenue Charles de Gaulle92104 Boulogne-Billancourt cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
          </listRelation>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-37712" status="VALID">
          <idno type="anr">ANR-10-COHO-0001</idno>
          <idno type="program">Cohortes</idno>
          <orgName>CKD-REIN</orgName>
          <desc>Maladie Rénale Chronique - Réseau Epidémiologie et Information en Néphrologie</desc>
          <date type="start">2010</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>