Comparison of high-flow nasal oxygen therapy and non-invasive ventilation in ICU patients with acute respiratory failure and a do-not-intubate orders: a multicentre prospective study OXYPAL - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles BMJ Open Year : 2021

Comparison of high-flow nasal oxygen therapy and non-invasive ventilation in ICU patients with acute respiratory failure and a do-not-intubate orders: a multicentre prospective study OXYPAL

1 CIC 1402 - CIC Poitiers – Centre d'investigation clinique de Poitiers
2 CHU de Poitiers [La Milétrie] - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
3 Université de Poitiers - Faculté de Médecine et de Pharmacie
4 SPHERE - MethodS in Patients-centered outcomes and HEalth ResEarch
5 CHB - Centre Hospitalier de Blois
6 CHU Rouen
7 Centre Hospitalier Le Mans (CH Le Mans)
8 CHU Tenon [AP-HP]
9 CH Roanne - Centre Hospitalier de Roanne
10 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
11 CHRO - Centre Hospitalier Régional d'Orléans
12 UMRS 1158 - Neurophysiologie Respiratoire Expérimentale et Clinique
13 CHU Pitié-Salpêtrière [AP-HP]
14 UNISTRA - Université de Strasbourg
15 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
16 CarMeN - Cardiovasculaire, métabolisme, diabétologie et nutrition
17 Université de Lyon
18 CHRU Brest - Centre Hospitalier Régional Universitaire de Brest
19 LaTIM - Laboratoire de Traitement de l'Information Medicale
20 CIC - Centre d’Investigation Clinique [Tours] CIC 1415
21 PRPA - Pathologies Respiratoires : Protéolyse et Aérosolthérapie
22 Réseau CRICS-TRIGGERSEP - Clinical Research in Intensive Care and Sepsis - TRIal Group for Global Evaluation and Research in SEPsis [CHU Limoges]
23 CH La Rochelle - Hôpital Saint-Louis de La Rochelle
24 CH E.Muller Mulhouse - Centre Hospitalier Emile Muller [Mulhouse]
25 CHU Gabriel Montpied [Clermont-Ferrand]
26 Hôpital Louis Mourier - AP-HP [Colombes]
27 Centre Hospitalier de Lens
28 Centre Hospitalier Victor Dupouy
29 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
30 CIC Lille - Centre d'Investigation Clinique - Innovation Technologique de Lille - CIC 1403 - CIC 9301
31 Groupe Hospitalier Nord Essonne [Longjumeau]
32 CH Béthune Beuvry - Centre Hospitalier de Béthune Beuvry
33 Hôpital Louis Pasteur [Chartres]
34 UCL - Université catholique de Lille
35 Groupe hospitalier Pellegrin
36 CHU Saint-Antoine [AP-HP]
37 Centre Hospitalier Privé Claude Galien - Ramsay Santé
38 Service de Réanimation Médicale (CHU de Dijon)
39 UBFC - Université Bourgogne Franche-Comté [COMUE]
40 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
41 HEGP - Hôpital Européen Georges Pompidou [APHP]
C. Girault
  • Function : Author
M. Djibre
  • Function : Author
N. Terzi
A. Boyer
B. Guidet

Abstract

INTRODUCTION: A palliative approach to intensive care unit (ICU) patients with acute respiratory failure and a do-not-intubate order corresponds to a poorly evaluated target for non-invasive oxygenation treatments. Survival alone should not be the only target; it also matters to avoid discomfort and to restore the patient's quality of life. We aim to conduct a prospective multicentre observational study to analyse clinical practices and their impact on outcomes of palliative high-flow nasal oxygen therapy (HFOT) and non-invasive ventilation (NIV) in ICU patients with do-not-intubate orders. METHODS AND ANALYSIS: This is an investigator-initiated, multicentre prospective observational cohort study comparing the three following strategies of oxygenation: HFOT alone, NIV alternating with HFOT and NIV alternating with standard oxygen in patients admitted in the ICU for acute respiratory failure with a do-not-intubate order. The primary outcome is the hospital survival within 14 days after ICU admission in patients weaned from NIV and HFOT. The sample size was estimated at a minimum of 330 patients divided into three groups according to the oxygenation strategy applied. The analysis takes into account confounding factors by modelling a propensity score. ETHICS AND DISSEMINATION: The study has been approved by the ethics committee and patients will be included after informed consent. The results will be submitted for publication in peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT03673631.
Fichier principal
Vignette du fichier
e045659.full.pdf (331.83 Ko) Télécharger le fichier
Origin Publication funded by an institution

Dates and versions

inserm-03328426 , version 1 (30-08-2021)

Identifiers

Cite

R. Robert, D. Frasca, J. Badin, C. Girault, C. Guitton, et al.. Comparison of high-flow nasal oxygen therapy and non-invasive ventilation in ICU patients with acute respiratory failure and a do-not-intubate orders: a multicentre prospective study OXYPAL. BMJ Open, 2021, 11 (2), pp.e045659. ⟨10.1136/bmjopen-2020-045659⟩. ⟨inserm-03328426⟩
103 View
55 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More