Overview of the Most Promising Radionuclides for Targeted Alpha Therapy: The “Hopeful Eight”
Résumé
Among all existing radionuclides, only a few are of interest for therapeutic applications and
more specifically for targeted alpha therapy (TAT). From this selection, actinium-225, astatine-211,
bismuth-212, bismuth-213, lead-212, radium-223, terbium-149 and thorium-227 are considered as the
most suitable. Despite common general features, they all have their own physical characteristics that
make them singular and so promising for TAT. These radionuclides were largely studied over the
last two decades, leading to a better knowledge of their production process and chemical behavior,
allowing for an increasing number of biological evaluations. The aim of this review is to summarize
the main properties of these eight chosen radionuclides. An overview from their availability to the
resulting clinical studies, by way of chemical design and preclinical studies is discussed.
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