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            <funder>The study was supported in part by ANR-19-CE36-0005-01 NIRVANA, Inserm Aviesan Itmo santé publique, the Scientific committee “AGIR for chronic diseases,” grant F4605 of the Austrian Science Fund (FWF), by a grant from the Country of Lower Austria and by the Megagrant of the Government of the Russian Federation, grant number 14.W03.31.0024 to RV, and by the European Commission's Seventh Framework Program MeDALL under grant agreement no. 261357. Genotyping was supported grant from the European Commission (No. LSHB-CT-2006-018996-GABRIEL).</funder>
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                <title xml:lang="en">Associations between specific IgE sensitization to 26 respiratory allergen molecules and HLA class II alleles in the EGEA cohort</title>
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                    <forename type="first">Valérie</forename>
                    <surname>Siroux</surname>
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                <idno type="issn">0105-4538</idno>
                <idno type="eissn">1398-9995</idno>
                <title level="j">Allergy</title>
                <imprint>
                  <publisher>Wiley</publisher>
                  <biblScope unit="volume">76</biblScope>
                  <biblScope unit="issue">8</biblScope>
                  <biblScope unit="pp">2575-2586</biblScope>
                  <date type="datePub">2021-08</date>
                  <date type="dateEpub">2021-03-19</date>
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              <idno type="doi">10.1111/all.14820</idno>
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              <keywords scheme="author">
                <term xml:lang="en">Respiratory allergen</term>
                <term xml:lang="en">Specific IgE.</term>
                <term xml:lang="en">MeDALL allergen-chip</term>
                <term xml:lang="en">Genetic epidemiology</term>
                <term xml:lang="en">HLA class-II genes</term>
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              <classCode scheme="halDomain" n="sdv.spee">Life Sciences [q-bio]/Santé publique et épidémiologie</classCode>
              <classCode scheme="halDomain" n="sdv.mhep.psr">Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract</classCode>
              <classCode scheme="halDomain" n="sdv.gen">Life Sciences [q-bio]/Genetics</classCode>
              <classCode scheme="halDomain" n="sdv.imm">Life Sciences [q-bio]/Immunology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
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              <p>Background: Allergy, the most frequent immune disorder affecting 30% of the world's population, is the consequence of immunoglobin E (IgE) sensitization to allergens. Among the genetic factors suspected to be involved in allergy, the HLA class-II genomic region is a strong candidate.Objective: To assess the association between HLA class-II alleles and specific IgE (sIgE) sensitization to a large number of respiratory allergen molecules.Methods: The analysis relied on 927 participants of the EGEA cohort, including 497 asthmatics. The study focuses on 26 aeroallergens recognized by sIgE in at least 5% of the study population (determined with the MEDALL chip with sIgE ≥ 0.3 ISU) and 23 imputed HLA class-II alleles. For each sIgE sensitization and HLA class-II allele, we fitted a logistic regression model accounting for familial dependence and adjusted for gender, age, and genetic principal components. p-values were corrected for multiple comparisons (False Discovery Rate).Results: Most of the 19 statistically significant associations observed regard pollen allergens (mugwort Art v 1, olive tree Ole e 1, timothy grass Phl p 2, Phl p 5 and plantain Pla l 1), three were mold allergen (Alternaria Alt a 1), and a single one regards house dust mite allergen (Der p 7). No association was observed with pet allergens. The strongest associations were found with mugwort Art v 1 (OR = 5.42 (95%CI, 3.30; 8.88), 4.14 (2.65; 6.47), 3.16 (1.88; 5.31) with DQB1*05:01, DQA1*01:01 and DRB1*01:01, respectively).Conclusion: Our results support the important role of HLA class-II alleles as immune response genes predisposing their carriers for sensitization to various major pollen allergens.</p>
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