<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of inserm-03261168</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-10T04:37:05+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">TNAP as a therapeutic target for cardiovascular calcification - a discussion of its pleiotropic functions in the body</title>
            <author role="aut">
              <persName>
                <forename type="first">C.</forename>
                <surname>Goettsch</surname>
              </persName>
              <idno type="halauthorid">2229728-0</idno>
              <affiliation ref="#struct-580269"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">A.</forename>
                <surname>Strzelecka-Kiliszek</surname>
              </persName>
              <idno type="halauthorid">373852-0</idno>
              <affiliation ref="#struct-67943"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">L.</forename>
                <surname>Bessueille</surname>
              </persName>
              <email type="md5">aaee9cfcbeefc93b86910c2fde789107</email>
              <email type="domain">univ-lyon1.fr</email>
              <idno type="idhal" notation="string">laurence-bessueille</idno>
              <idno type="idhal" notation="numeric">1504198</idno>
              <idno type="halauthorid" notation="string">200067-1504198</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4692-8077</idno>
              <affiliation ref="#struct-24487"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">T.</forename>
                <surname>Quillard</surname>
              </persName>
              <email type="md5">a9eef25c0666a31f613d5a5cefc625d4</email>
              <email type="domain">gmail.com</email>
              <idno type="idhal" notation="string">thibaut-quillard</idno>
              <idno type="idhal" notation="numeric">1367452</idno>
              <idno type="halauthorid" notation="string">1316576-1367452</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/K-8150-2015</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8096-2597</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/K-8150-2015</idno>
              <affiliation ref="#struct-523373"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">L.</forename>
                <surname>Mechtouff</surname>
              </persName>
              <email type="md5">89cc0e7d0aba197ae83d60497e0c5047</email>
              <email type="domain">chu-lyon.fr</email>
              <idno type="idhal" notation="numeric">1171166</idno>
              <idno type="halauthorid" notation="string">311815-1171166</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9165-5763</idno>
              <idno type="IDREF">https://www.idref.fr/121718751</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=h4c4AlEAAAAJ</idno>
              <idno type="VIAF">https://viaf.org/viaf/22465626</idno>
              <affiliation ref="#struct-300074"/>
              <affiliation ref="#struct-139739"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">S.</forename>
                <surname>Pikula</surname>
              </persName>
              <idno type="halauthorid">150259-0</idno>
              <affiliation ref="#struct-67943"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">E.</forename>
                <surname>Canet-Soulas</surname>
              </persName>
              <email type="md5">76b31f467dd53b24ecf1f775b96929f6</email>
              <email type="domain">univ-lyon1.fr</email>
              <idno type="idhal" notation="string">emmanuelle-canet-soulas</idno>
              <idno type="idhal" notation="numeric">841367</idno>
              <idno type="halauthorid" notation="string">182856-841367</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4742-5570</idno>
              <affiliation ref="#struct-1062221"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">J. L.</forename>
                <surname>Millán</surname>
              </persName>
              <idno type="halauthorid">2229729-0</idno>
              <affiliation ref="#struct-534344"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Caroline</forename>
                <surname>Fonta</surname>
              </persName>
              <email type="md5">fa3d00a6a2b1ff97048ed41577215f91</email>
              <email type="domain">cnrs.fr</email>
              <idno type="idhal" notation="string">caroline-fonta</idno>
              <idno type="idhal" notation="numeric">749915</idno>
              <idno type="halauthorid" notation="string">359072-749915</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/AAJ-2210-2020</idno>
              <idno type="IDREF">https://www.idref.fr/168807386</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6326-4044</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/AAJ-2210-2020</idno>
              <affiliation ref="#struct-1149092"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">D.</forename>
                <surname>Magne</surname>
              </persName>
              <idno type="halauthorid">344316-0</idno>
              <affiliation ref="#struct-24487"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>laboratoire</forename>
                <surname>CarMeN</surname>
              </persName>
              <email type="md5">ad01ffdd0e4524e1bba80c4bac397845</email>
              <email type="domain">inserm.fr</email>
            </editor>
            <funder ref="#projanr-54486"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2021-06-15 14:56:49</date>
              <date type="whenModified">2026-04-23 14:50:05</date>
              <date type="whenReleased">2021-10-28 17:01:37</date>
              <date type="whenProduced">2022</date>
              <date type="whenEndEmbargoed">2021-06-16</date>
              <ref type="file" target="https://inserm.hal.science/inserm-03261168v1/document">
                <date notBefore="2021-06-16"/>
              </ref>
              <ref type="file" subtype="publisherPaid" n="1" target="https://inserm.hal.science/inserm-03261168v1/file/cvaa299.pdf" id="file-3407475-2987999">
                <date notBefore="2021-06-16"/>
              </ref>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752354"/>
              <fs>
                <f name="inra_etatDocument_local" notation="numeric">
                  <numeric>0</numeric>
                </f>
                <f name="inra_etatDocument_local" notation="string" n="0">
                  <string>inra_etatDocument_local_0</string>
                </f>
                <f name="inra_publicVise_local" notation="string" n="SC">
                  <string>inra_publicVise_local_SC</string>
                </f>
              </fs>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="672787">
                <persName>
                  <forename>laboratoire</forename>
                  <surname>CarMeN</surname>
                </persName>
                <email type="md5">ad01ffdd0e4524e1bba80c4bac397845</email>
                <email type="domain">inserm.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">inserm-03261168</idno>
            <idno type="halUri">https://inserm.hal.science/inserm-03261168</idno>
            <idno type="halBibtex">goettsch:inserm-03261168</idno>
            <idno type="halRefHtml">&lt;i&gt;Cardiovascular Research&lt;/i&gt;, 2022, 118 (1), pp.84-96. &lt;a target="_blank" href="https://dx.doi.org/10.1093/cvr/cvaa299"&gt;&amp;#x27E8;10.1093/cvr/cvaa299&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Cardiovascular Research, 2022, 118 (1), pp.84-96. &amp;#x27E8;10.1093/cvr/cvaa299&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0 - Attribution<ref corresp="#file-3407475-2987999"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="UNIV-ST-ETIENNE">Université Jean Monnet - Saint-Etienne</idno>
            <idno type="stamp" n="HCL">Hospices Civils de Lyon</idno>
            <idno type="stamp" n="UNIV-TLSE2">Université Toulouse 2</idno>
            <idno type="stamp" n="UNIV-TLSE3">Université de Toulouse</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-LYON1">Université Claude Bernard - Lyon I</idno>
            <idno type="stamp" n="INSA-LYON">Institut National des Sciences Appliquées de Lyon</idno>
            <idno type="stamp" n="CERCO">Centre de Recherche Cerveau et Cognition</idno>
            <idno type="stamp" n="CREATIS" corresp="UNIV-LYON1">Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé</idno>
            <idno type="stamp" n="INC-CNRS">Institut de Chimie du CNRS</idno>
            <idno type="stamp" n="PHY-OS">Sarcomes Osseux et Remodelage des Tissus Calcifiés</idno>
            <idno type="stamp" n="CARMEN" corresp="INSERM">Cardiovasculaire, Métabolisme, Diabétologie et Nutrition</idno>
            <idno type="stamp" n="INSA-GROUPE">Groupe INSA</idno>
            <idno type="stamp" n="UDL">UDL</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
            <idno type="stamp" n="TEST-HALCNRS">Collection test HAL CNRS</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="NANTES-UNIVERSITE">Nantes Université</idno>
            <idno type="stamp" n="UNIV-UT3">Université Toulouse 3</idno>
            <idno type="stamp" n="UT3-INP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="UT3-TOULOUSEINP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="RESEAU-EAU">Réseau "Systèmes Agricoles et Eau"</idno>
            <idno type="stamp" n="UFR-MEDECINE-NANTES">UFR de médecine - Nantes Université</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">TNAP as a therapeutic target for cardiovascular calcification - a discussion of its pleiotropic functions in the body</title>
                <author role="aut">
                  <persName>
                    <forename type="first">C.</forename>
                    <surname>Goettsch</surname>
                  </persName>
                  <idno type="halauthorid">2229728-0</idno>
                  <affiliation ref="#struct-580269"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">A.</forename>
                    <surname>Strzelecka-Kiliszek</surname>
                  </persName>
                  <idno type="halauthorid">373852-0</idno>
                  <affiliation ref="#struct-67943"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">L.</forename>
                    <surname>Bessueille</surname>
                  </persName>
                  <email type="md5">aaee9cfcbeefc93b86910c2fde789107</email>
                  <email type="domain">univ-lyon1.fr</email>
                  <idno type="idhal" notation="string">laurence-bessueille</idno>
                  <idno type="idhal" notation="numeric">1504198</idno>
                  <idno type="halauthorid" notation="string">200067-1504198</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4692-8077</idno>
                  <affiliation ref="#struct-24487"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">T.</forename>
                    <surname>Quillard</surname>
                  </persName>
                  <email type="md5">a9eef25c0666a31f613d5a5cefc625d4</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="string">thibaut-quillard</idno>
                  <idno type="idhal" notation="numeric">1367452</idno>
                  <idno type="halauthorid" notation="string">1316576-1367452</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/K-8150-2015</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8096-2597</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/K-8150-2015</idno>
                  <affiliation ref="#struct-523373"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">L.</forename>
                    <surname>Mechtouff</surname>
                  </persName>
                  <email type="md5">89cc0e7d0aba197ae83d60497e0c5047</email>
                  <email type="domain">chu-lyon.fr</email>
                  <idno type="idhal" notation="numeric">1171166</idno>
                  <idno type="halauthorid" notation="string">311815-1171166</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9165-5763</idno>
                  <idno type="IDREF">https://www.idref.fr/121718751</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=h4c4AlEAAAAJ</idno>
                  <idno type="VIAF">https://viaf.org/viaf/22465626</idno>
                  <affiliation ref="#struct-300074"/>
                  <affiliation ref="#struct-139739"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">S.</forename>
                    <surname>Pikula</surname>
                  </persName>
                  <idno type="halauthorid">150259-0</idno>
                  <affiliation ref="#struct-67943"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">E.</forename>
                    <surname>Canet-Soulas</surname>
                  </persName>
                  <email type="md5">76b31f467dd53b24ecf1f775b96929f6</email>
                  <email type="domain">univ-lyon1.fr</email>
                  <idno type="idhal" notation="string">emmanuelle-canet-soulas</idno>
                  <idno type="idhal" notation="numeric">841367</idno>
                  <idno type="halauthorid" notation="string">182856-841367</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4742-5570</idno>
                  <affiliation ref="#struct-1062221"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J. L.</forename>
                    <surname>Millán</surname>
                  </persName>
                  <idno type="halauthorid">2229729-0</idno>
                  <affiliation ref="#struct-534344"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Caroline</forename>
                    <surname>Fonta</surname>
                  </persName>
                  <email type="md5">fa3d00a6a2b1ff97048ed41577215f91</email>
                  <email type="domain">cnrs.fr</email>
                  <idno type="idhal" notation="string">caroline-fonta</idno>
                  <idno type="idhal" notation="numeric">749915</idno>
                  <idno type="halauthorid" notation="string">359072-749915</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/AAJ-2210-2020</idno>
                  <idno type="IDREF">https://www.idref.fr/168807386</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6326-4044</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/AAJ-2210-2020</idno>
                  <affiliation ref="#struct-1149092"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">D.</forename>
                    <surname>Magne</surname>
                  </persName>
                  <idno type="halauthorid">344316-0</idno>
                  <affiliation ref="#struct-24487"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">11528</idno>
                <idno type="issn">0008-6363</idno>
                <title level="j">Cardiovascular Research</title>
                <imprint>
                  <publisher>Oxford University Press (OUP)</publisher>
                  <biblScope unit="volume">118</biblScope>
                  <biblScope unit="issue">1</biblScope>
                  <biblScope unit="pp">84-96</biblScope>
                  <date type="datePub">2022</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1093/cvr/cvaa299</idno>
              <idno type="pubmed">33070177</idno>
              <idno type="wos">000743142600017</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Inflammation</term>
                <term xml:lang="en">Inhibition</term>
                <term xml:lang="en">Tissue non-specific alkaline phosphatase</term>
                <term xml:lang="en">Therapeutic target</term>
                <term xml:lang="en">Cardiovascular calcification</term>
                <term xml:lang="en">Inflammation</term>
                <term xml:lang="en">Inflammation</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART.ARTREV">Journal articles - Review article</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Cardiovascular calcification (CVC) is associated with increased morbidity and mortality. It develops in several diseases and locations, such as in the tunica intima in atherosclerosis plaques, in the tunica media in type 2 diabetes and chronic kidney disease, and in aortic valves. In spite of the wide occurrence of CVC and its detrimental effects on cardiovascular diseases (CVD), no treatment is yet available. Most of CVC involve mechanisms similar to those occurring during endochondral and/or intramembranous ossification. Logically, since tissue-nonspecific alkaline phosphatase (TNAP) is the key-enzyme responsible for skeletal/dental mineralization, it is a promising target to limit CVC. Tools have recently been developed to inhibit its activity and preclinical studies conducted in animal models of vascular calcification already provided promising results. Nevertheless, as its name indicates, TNAP is ubiquitous and recent data indicate that it dephosphorylates different substrates in vivo to participate in other important physiological functions besides mineralization. For instance, TNAP is involved in the metabolism of pyridoxal phosphate and the production of neurotransmitters. TNAP has also been described as an anti-inflammatory enzyme able to dephosphorylate adenosine nucleotides and lipopolysaccharide. A better understanding of the full spectrum of TNAP's functions is needed to better characterize the effects of TNAP inhibition in diseases associated with CVC. In this review, after a brief description of the different types of CVC, we describe the newly uncovered additional functions of TNAP and discuss the expected consequences of its systemic inhibition in vivo.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="regrouplaboratory" xml:id="struct-580269" status="VALID">
          <orgName>Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany]</orgName>
          <orgName type="acronym">UKA</orgName>
          <desc>
            <address>
              <addrLine>Universitätsklinikum Aachen, AöR -Pauwelsstraße 30 -52074 Aachen</addrLine>
              <country key="DE"/>
            </address>
            <ref type="url">https://www.rwth-aachen.de/go/id/unk/lidx/1</ref>
          </desc>
          <listRelation>
            <relation active="#struct-303510" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-67943" status="VALID">
          <orgName>Nencki Institute of Experimental Biology</orgName>
          <desc>
            <address>
              <addrLine>WARSAW</addrLine>
              <country key="PL"/>
            </address>
            <ref type="url">http://www.nencki.gov.pl</ref>
          </desc>
          <listRelation>
            <relation active="#struct-303306" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-24487" status="VALID">
          <idno type="IdRef">149115806</idno>
          <idno type="ISNI">0000000122475857</idno>
          <idno type="RNSR">200711911W</idno>
          <idno type="ROR">https://ror.org/00gj33s30</idno>
          <orgName>Institut de Chimie et Biochimie Moléculaires et Supramoléculaires</orgName>
          <orgName type="acronym">ICBMS</orgName>
          <date type="start">2006-01-01</date>
          <desc>
            <address>
              <addrLine>ICBMS UMR 5246 CNRS, Université de Lyon, Université Lyon 1, CNRS, INSA Lyon, CPE Lyon, bâtiment Lederer, 1 rue Victor Grignard, 69622 Villeurbanne Cedex, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.icbms.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-194495" type="direct"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-210962" type="direct"/>
            <relation active="#struct-219748" type="direct"/>
            <relation active="#struct-301232" type="indirect"/>
            <relation active="#struct-341038" type="direct"/>
            <relation name="UMR5246" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-523373" status="OLD">
          <orgName>Sarcomes osseux et remodelage des tissus calcifiés - Phy-Os [Nantes - INSERM U1238]</orgName>
          <orgName type="acronym">Phy-Os</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>Faculté de médecine - 1 rue Gaston Veil 44035 Nantes Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.umr1238.univ-nantes.fr/</ref>
          </desc>
          <listRelation>
            <relation name="U1238" active="#struct-303623" type="direct"/>
            <relation active="#struct-469973" type="direct"/>
            <relation active="#struct-474972" type="direct"/>
            <relation active="#struct-531638" type="direct"/>
            <relation active="#struct-93263" type="indirect"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-300074" status="VALID">
          <idno type="IdRef">026534657</idno>
          <idno type="ROR">https://ror.org/01502ca60</idno>
          <orgName>Hospices Civils de Lyon</orgName>
          <orgName type="acronym">HCL</orgName>
          <desc>
            <address>
              <addrLine>3 Quai des Célestins69002 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/hospices-civils-de-lyon-hcl</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-139739" status="VALID">
          <idno type="IdRef">19513270X</idno>
          <idno type="ISNI">0000000406380358</idno>
          <idno type="RNSR">200717526Z</idno>
          <idno type="ROR">https://ror.org/03smk3872</idno>
          <orgName>Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé</orgName>
          <orgName type="acronym">CREATIS</orgName>
          <date type="start">2007-01-01</date>
          <desc>
            <address>
              <addrLine>7 avenue Jean Capelle, Bat Blaise Pascal, 69621 Villeurbanne Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.creatis.insa-lyon.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-194495" type="direct"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-219748" type="direct"/>
            <relation active="#struct-301232" type="indirect"/>
            <relation active="#struct-300284" type="direct"/>
            <relation active="#struct-1327915" type="indirect"/>
            <relation name="U1206" active="#struct-303623" type="direct"/>
            <relation name="UMR5220" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1062221" status="VALID">
          <idno type="IdRef">149700210</idno>
          <idno type="ISNI">0000000406205541</idno>
          <idno type="RNSR">201119381Y</idno>
          <orgName>Cardiovasculaire, métabolisme, diabétologie et nutrition</orgName>
          <orgName type="acronym">CarMeN</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de Médecine Lyon Sud - BP 12 - 165 Chemin du Grand Revoyet - 69921 Oullins cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://carmen.univ-lyon1.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UM92" active="#struct-194495" type="direct"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-300074" type="direct"/>
            <relation name="U1060" active="#struct-303623" type="direct"/>
            <relation name="UMR1397" active="#struct-577435" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-534344" status="VALID">
          <idno type="ROR">https://ror.org/03m1g2s55</idno>
          <orgName>Sanford Burnham Prebys Medical Discovery Institute</orgName>
          <desc>
            <address>
              <addrLine>La Jolla, CA, 92037</addrLine>
              <country key="US"/>
            </address>
            <ref type="url">https://www.sbpdiscovery.org/about</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1149092" status="OLD">
          <idno type="IdRef">179351788</idno>
          <idno type="ISNI">0000 0000 8523 0913</idno>
          <idno type="RNSR">199311991U</idno>
          <idno type="ROR">https://ror.org/04fhrs205</idno>
          <orgName>Centre de recherche cerveau et cognition</orgName>
          <orgName type="acronym">CERCO UMR5549</orgName>
          <date type="start">2021-01-01</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>CHU Purpan - Pavillon Baudot BP 25202 31052 Toulouse Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://cerco.cnrs.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-217752" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation name="UMR5549" active="#struct-441569" type="direct"/>
            <relation active="#struct-1149079" type="direct"/>
            <relation active="#struct-116256" type="indirect"/>
            <relation name="FED4171" active="#struct-217752" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-303510" status="VALID">
          <idno type="IdRef">074130323</idno>
          <idno type="ISNI">000000010728696X</idno>
          <idno type="ROR">https://ror.org/04xfq0f34</idno>
          <idno type="Wikidata">Q273263</idno>
          <orgName>RWTH Aachen University = Rheinisch-Westfälische Technische Hochschule Aachen</orgName>
          <orgName type="acronym">RWTH Aachen</orgName>
          <date type="start">1870-01-01</date>
          <desc>
            <address>
              <addrLine>RWTH Aachen –  Templergraben 55 – 52062 Aachen (Hausanschrift) – 52056 Aachen (Postanschrift) – Deutschland</addrLine>
              <country key="DE"/>
            </address>
            <ref type="url">http://www.rwth-aachen.de/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303306" status="VALID">
          <idno type="ROR">https://ror.org/01dr6c206</idno>
          <orgName>Polska Akademia Nauk = Polish Academy of Sciences = Académie polonaise des sciences</orgName>
          <orgName type="acronym">PAN</orgName>
          <date type="start">1951-10-01</date>
          <desc>
            <address>
              <addrLine>Pałac Kultury i Nauki, pl. Defilad 1, 00-901 Warszawa, skrytka pocztowa 24, Polska</addrLine>
              <country key="PL"/>
            </address>
            <ref type="url">https://www.pan.pl</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-194495" status="VALID">
          <idno type="IdRef">026402823</idno>
          <idno type="ISNI">0000000121686185</idno>
          <idno type="ROR">https://ror.org/029brtt94</idno>
          <orgName>Université Claude Bernard Lyon 1</orgName>
          <orgName type="acronym">UCBL</orgName>
          <desc>
            <address>
              <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-lyon1.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301088" status="VALID">
          <idno type="ROR">https://ror.org/01rk35k63</idno>
          <orgName>Université de Lyon</orgName>
          <desc>
            <address>
              <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-lyon.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-210962" status="VALID">
          <orgName>École Supérieure de Chimie Physique Électronique de Lyon</orgName>
          <orgName type="acronym">CPE</orgName>
          <desc>
            <address>
              <addrLine>Domaine Scientifique de la DouaBâtiment Hubert Curien 43 Boulevard du 11 Novembre 191869616 Villeurbanne</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cpe.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-219748" status="VALID">
          <idno type="IdRef">052444724</idno>
          <idno type="ISNI">0000 0001 2292 0228</idno>
          <orgName>Institut National des Sciences Appliquées de Lyon</orgName>
          <orgName type="acronym">INSA Lyon</orgName>
          <date type="start">1957-03-18</date>
          <desc>
            <address>
              <addrLine>20 Avenue Albert Einstein, 69621 Villeurbanne cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.insa-lyon.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
            <relation active="#struct-301232" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301232" status="VALID">
          <idno type="IdRef">162105150</idno>
          <orgName>Institut National des Sciences Appliquées</orgName>
          <orgName type="acronym">INSA</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-341038" status="VALID">
          <idno type="IdRef">232435103</idno>
          <idno type="ISNI">000000010626358X</idno>
          <idno type="ROR">https://ror.org/02cte4b68</idno>
          <orgName>Institut de Chimie - CNRS Chimie</orgName>
          <orgName type="acronym">INC-CNRS</orgName>
          <date type="start">2009-10-01</date>
          <desc>
            <address>
              <addrLine>CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 rue Michel-Ange75794 PARIS CEDEX 16 - France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cnrs.fr/inc</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-469973" status="VALID">
          <idno type="IdRef">191639044</idno>
          <idno type="ROR">https://ror.org/04x1a4s97</idno>
          <orgName>Université Bretagne Loire</orgName>
          <orgName type="acronym">UBL</orgName>
          <date type="start">2016-04-01</date>
          <desc>
            <address>
              <addrLine>Cité Internationale, 1 place Paul Ricoeur - CS 54417 35044 RENNES CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://u-bretagneloire.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-474972" status="VALID">
          <idno type="IdRef">034926445</idno>
          <idno type="ROR">https://ror.org/05c1qsg97</idno>
          <idno type="Wikidata">Q2945767</idno>
          <orgName>Centre Hospitalier Universitaire de Nantes = Nantes University Hospital</orgName>
          <orgName type="acronym">CHU Nantes</orgName>
          <desc>
            <address>
              <addrLine>1 Place Alexis-Ricordeau, 44000 Nantes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-nantes.fr</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-531638" status="OLD">
          <idno type="IdRef">076954927</idno>
          <orgName>Université de Nantes - UFR de Médecine et des Techniques Médicales</orgName>
          <orgName type="acronym">UFR MEDECINE</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>1 rue Gaston Veil BP 53508 44035 NANTES Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.medecine.univ-nantes.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-93263" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-93263" status="OLD">
          <idno type="IdRef">026403447</idno>
          <idno type="ROR">https://ror.org/03gnr7b55</idno>
          <orgName>Université de Nantes</orgName>
          <orgName type="acronym">UN</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>1, quai de Tourville - BP 13522 - 44035 Nantes cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-nantes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300284" status="VALID">
          <idno type="IdRef">028209966</idno>
          <idno type="ISNI">0000 0001 2158 1682</idno>
          <idno type="ROR">https://ror.org/04yznqr36</idno>
          <idno type="Wikidata">Q623154</idno>
          <orgName>Université Jean Monnet - Saint-Étienne</orgName>
          <orgName type="acronym">UJM</orgName>
          <date type="start">1969-03-27</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>10, Rue Tréfilerie – CS 8230142023 Saint-Étienne Cedex 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-st-etienne.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1327915" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-1327915" status="VALID">
          <idno type="IdRef">285395831</idno>
          <orgName>Université Jean Monnet (EPSCPE)</orgName>
          <orgName type="acronym">UJM EPE</orgName>
          <date type="start">2025-01-01</date>
          <desc>
            <address>
              <addrLine>10 rue Tréfilerie42100 Saint-Etienne</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-st-etienne.fr/fr/index.html</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-577435" status="VALID">
          <idno type="ROR">https://ror.org/003vg9w96</idno>
          <orgName>Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement</orgName>
          <orgName type="acronym">INRAE</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-217752" status="OLD">
          <idno type="IdRef">026404672</idno>
          <idno type="ISNI">0000000121617331</idno>
          <idno type="ROR">https://ror.org/02v6kpv12</idno>
          <idno type="Wikidata">Q1273188</idno>
          <orgName>Université Toulouse III - Paul Sabatier</orgName>
          <orgName type="acronym">UT3</orgName>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-tlse3.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-443875" status="VALID">
          <idno type="ROR">https://ror.org/017tgbk05</idno>
          <orgName>Communauté d'universités et établissements de Toulouse</orgName>
          <orgName type="acronym">Comue de Toulouse</orgName>
          <desc>
            <address>
              <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-toulouse.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-1149079" status="OLD">
          <orgName>Toulouse Mind &amp; Brain Institut</orgName>
          <orgName type="acronym">TMBI</orgName>
          <date type="start">2021-01-01</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>CHU Purpan, Pavillon Baudot, 31059 Toulouse cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.tmbi.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-116256" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation name="FED4171" active="#struct-217752" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-116256" status="VALID">
          <idno type="IdRef">026403994</idno>
          <idno type="ROR">https://ror.org/04ezk3x31</idno>
          <orgName>Université Toulouse - Jean Jaurès</orgName>
          <orgName type="acronym">UT2J</orgName>
          <date type="start">1971-01-01</date>
          <desc>
            <address>
              <addrLine>5 allées Antonio Machado - 31058 Toulouse Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-tlse2.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-54486" status="VALID">
          <idno type="anr">ANR-17-ECVD-0003</idno>
          <orgName>MICROEXPLORATION</orgName>
          <desc>Exploring the effects of microcalcification on plaque vulnerability</desc>
          <date type="start">2017</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>