<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of inserm-02941495</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-18T07:07:57+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Localized Intrathecal Delivery of Mesenchymal Stromal Cells Conditioned Medium Improves Functional Recovery in a Rat Model of Spinal Cord Injury</title>
            <author role="aut">
              <persName>
                <forename type="first">Dasa</forename>
                <surname>Cizkova</surname>
              </persName>
              <idno type="halauthorid">1390285-0</idno>
              <affiliation ref="#struct-335170"/>
              <affiliation ref="#struct-1050941"/>
              <affiliation ref="#struct-443423"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Veronika</forename>
                <surname>Cubinkova</surname>
              </persName>
              <idno type="halauthorid">2027477-0</idno>
              <affiliation ref="#struct-335170"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Tomas</forename>
                <surname>Smolek</surname>
              </persName>
              <idno type="halauthorid">2027750-0</idno>
              <affiliation ref="#struct-335170"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Adriana-Natalia</forename>
                <surname>Murgoci</surname>
              </persName>
              <idno type="halauthorid">2026329-0</idno>
              <affiliation ref="#struct-335170"/>
              <affiliation ref="#struct-1050941"/>
              <affiliation ref="#struct-443423"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jan</forename>
                <surname>Danko</surname>
              </persName>
              <idno type="halauthorid">2027751-0</idno>
              <affiliation ref="#struct-1050941"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Katarina</forename>
                <surname>Vdoviakova</surname>
              </persName>
              <idno type="halauthorid">2027752-0</idno>
              <affiliation ref="#struct-1050941"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Filip</forename>
                <surname>Humenik</surname>
              </persName>
              <idno type="halauthorid">2027753-0</idno>
              <affiliation ref="#struct-1050941"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Milan</forename>
                <surname>Cizek</surname>
              </persName>
              <idno type="halauthorid">2026333-0</idno>
              <affiliation ref="#struct-1050941"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jusal</forename>
                <surname>Quanico</surname>
              </persName>
              <idno type="halauthorid">1405659-0</idno>
              <affiliation ref="#struct-443423"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Isabelle</forename>
                <surname>Fournier</surname>
              </persName>
              <email type="md5">c8d6435baa6f79883eb3cebb6e3f80c6</email>
              <email type="domain">univ-lille.fr</email>
              <idno type="idhal" notation="string">isabelle-fournier</idno>
              <idno type="idhal" notation="numeric">173955</idno>
              <idno type="halauthorid" notation="string">44252-173955</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/H-9195-2015</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1096-5044</idno>
              <idno type="IDREF">https://www.idref.fr/137267029</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/H-9195-2015</idno>
              <affiliation ref="#struct-443423"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Michel</forename>
                <surname>Salzet</surname>
              </persName>
              <email type="md5">4ccc1872502c4da909438af3b03398cd</email>
              <email type="domain">univ-lille.fr</email>
              <idno type="idhal" notation="string">michel-salzet</idno>
              <idno type="idhal" notation="numeric">1299890</idno>
              <idno type="halauthorid" notation="string">171781-1299890</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4318-0817</idno>
              <idno type="IDREF">https://www.idref.fr/069436940</idno>
              <affiliation ref="#struct-443423"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Michel</forename>
                <surname>SALZET</surname>
              </persName>
              <email type="md5">4ccc1872502c4da909438af3b03398cd</email>
              <email type="domain">univ-lille.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2020-09-17 09:57:36</date>
              <date type="whenModified">2025-12-16 16:10:02</date>
              <date type="whenReleased">2020-09-21 10:34:41</date>
              <date type="whenProduced">2018-03</date>
              <date type="whenEndEmbargoed">2020-09-21</date>
              <ref type="file" target="https://inserm.hal.science/inserm-02941495v1/document">
                <date notBefore="2020-09-21"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://inserm.hal.science/inserm-02941495v1/file/ijms-19-00870-v2.pdf" id="file-2941495-2591651">
                <date notBefore="2020-09-21"/>
              </ref>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877731"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="456935">
                <persName>
                  <forename>Michel</forename>
                  <surname>SALZET</surname>
                </persName>
                <email type="md5">4ccc1872502c4da909438af3b03398cd</email>
                <email type="domain">univ-lille.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">inserm-02941495</idno>
            <idno type="halUri">https://inserm.hal.science/inserm-02941495</idno>
            <idno type="halBibtex">cizkova:inserm-02941495</idno>
            <idno type="halRefHtml">&lt;i&gt;International Journal of Molecular Sciences&lt;/i&gt;, 2018, 19 (3), pp.870. &lt;a target="_blank" href="https://dx.doi.org/10.3390/ijms19030870"&gt;&amp;#x27E8;10.3390/ijms19030870&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">International Journal of Molecular Sciences, 2018, 19 (3), pp.870. &amp;#x27E8;10.3390/ijms19030870&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-2941495-2591651"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="UNIV-LILLE">Université de Lille</idno>
            <idno type="stamp" n="PRISM-LILLE"> Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Localized Intrathecal Delivery of Mesenchymal Stromal Cells Conditioned Medium Improves Functional Recovery in a Rat Model of Spinal Cord Injury</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Dasa</forename>
                    <surname>Cizkova</surname>
                  </persName>
                  <idno type="halauthorid">1390285-0</idno>
                  <affiliation ref="#struct-335170"/>
                  <affiliation ref="#struct-1050941"/>
                  <affiliation ref="#struct-443423"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Veronika</forename>
                    <surname>Cubinkova</surname>
                  </persName>
                  <idno type="halauthorid">2027477-0</idno>
                  <affiliation ref="#struct-335170"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Tomas</forename>
                    <surname>Smolek</surname>
                  </persName>
                  <idno type="halauthorid">2027750-0</idno>
                  <affiliation ref="#struct-335170"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Adriana-Natalia</forename>
                    <surname>Murgoci</surname>
                  </persName>
                  <idno type="halauthorid">2026329-0</idno>
                  <affiliation ref="#struct-335170"/>
                  <affiliation ref="#struct-1050941"/>
                  <affiliation ref="#struct-443423"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jan</forename>
                    <surname>Danko</surname>
                  </persName>
                  <idno type="halauthorid">2027751-0</idno>
                  <affiliation ref="#struct-1050941"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Katarina</forename>
                    <surname>Vdoviakova</surname>
                  </persName>
                  <idno type="halauthorid">2027752-0</idno>
                  <affiliation ref="#struct-1050941"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Filip</forename>
                    <surname>Humenik</surname>
                  </persName>
                  <idno type="halauthorid">2027753-0</idno>
                  <affiliation ref="#struct-1050941"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Milan</forename>
                    <surname>Cizek</surname>
                  </persName>
                  <idno type="halauthorid">2026333-0</idno>
                  <affiliation ref="#struct-1050941"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jusal</forename>
                    <surname>Quanico</surname>
                  </persName>
                  <idno type="halauthorid">1405659-0</idno>
                  <affiliation ref="#struct-443423"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Isabelle</forename>
                    <surname>Fournier</surname>
                  </persName>
                  <email type="md5">c8d6435baa6f79883eb3cebb6e3f80c6</email>
                  <email type="domain">univ-lille.fr</email>
                  <idno type="idhal" notation="string">isabelle-fournier</idno>
                  <idno type="idhal" notation="numeric">173955</idno>
                  <idno type="halauthorid" notation="string">44252-173955</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/H-9195-2015</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1096-5044</idno>
                  <idno type="IDREF">https://www.idref.fr/137267029</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/H-9195-2015</idno>
                  <affiliation ref="#struct-443423"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Michel</forename>
                    <surname>Salzet</surname>
                  </persName>
                  <email type="md5">4ccc1872502c4da909438af3b03398cd</email>
                  <email type="domain">univ-lille.fr</email>
                  <idno type="idhal" notation="string">michel-salzet</idno>
                  <idno type="idhal" notation="numeric">1299890</idno>
                  <idno type="halauthorid" notation="string">171781-1299890</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4318-0817</idno>
                  <idno type="IDREF">https://www.idref.fr/069436940</idno>
                  <affiliation ref="#struct-443423"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">877092</idno>
                <idno type="issn">1661-6596</idno>
                <idno type="eissn">1422-0067</idno>
                <title level="j">International Journal of Molecular Sciences</title>
                <imprint>
                  <publisher>MDPI</publisher>
                  <biblScope unit="volume">19</biblScope>
                  <biblScope unit="issue">3</biblScope>
                  <biblScope unit="pp">870</biblScope>
                  <date type="datePub">2018-03</date>
                </imprint>
              </monogr>
              <idno type="doi">10.3390/ijms19030870</idno>
              <idno type="pubmed">29543759</idno>
              <idno type="pubmedcentral">PMC5877731</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">inflammation</term>
                <term xml:lang="en">regeneration</term>
                <term xml:lang="en">spinal cord injury</term>
                <term xml:lang="en">stem cells-derived conditioned media</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>It was recently shown that the conditioned medium (CM) of mesenchymal stem cells can enhance viability of neural and glial cell populations. In the present study, we have investigated a cell-free approach via CM from rat bone marrow stromal cells (MScCM) applied intrathecally (IT) for spinal cord injury (SCI) recovery in adult rats. Functional in vitro test on dorsal root ganglion (DRG) primary cultures confirmed biological properties of collected MScCM for production of neurosphere-like structures and axon outgrowth. Afterwards, rats underwent SCI and were treated with IT delivery of MScCM or vehicle at postsurgical Days 1, 5, 9, and 13, and left to survive 10 weeks. Rats that received MScCM showed significantly higher motor function recovery, increase in spared spinal cord tissue, enhanced GAP-43 expression and attenuated inflammation in comparison with vehicle-treated rats. Spared tissue around the lesion site was infiltrated with GAP-43-labeled axons at four weeks that gradually decreased at 10 weeks. Finally, a cytokine array performed on spinal cord extracts after MScCM treatment revealed decreased levels of IL-2, IL-6 and TNFα when compared to vehicle group. In conclusion, our results suggest that molecular cocktail found in MScCM is favorable for final neuroregeneration after SCI.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-335170" status="VALID">
          <idno type="IdRef">026421569</idno>
          <idno type="ISNI">0000 0001 2180 9405</idno>
          <idno type="ROR">https://ror.org/03h7qq074</idno>
          <idno type="Wikidata">Q1050317</idno>
          <orgName>Slovak Academy of Sciences [Bratislava]</orgName>
          <orgName type="acronym">SAS</orgName>
          <date type="start">1953-01-01</date>
          <desc>
            <address>
              <addrLine>Slovenská akadémia vied, Štefánikova 49, 814 38 Bratislava</addrLine>
              <country key="SK"/>
            </address>
            <ref type="url">https://www.sav.sk/?lang=en</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1050941" status="VALID">
          <orgName>University of Veterinary Medicine and Pharmacy [Košice, Slovakia]</orgName>
          <desc>
            <address>
              <country key="SK"/>
            </address>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-443423" status="VALID">
          <idno type="IdRef">161573533</idno>
          <idno type="RNSR">201119484K</idno>
          <idno type="ROR">https://ror.org/05dm3m993</idno>
          <idno type="Wikidata">Q30262542</idno>
          <orgName>Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192</orgName>
          <orgName type="acronym">PRISM</orgName>
          <date type="start">2015-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lille - Campus Cité Scientifique - Faculté des Sciences et Technologies - Département de Biologie -- Avenue Paul Langevin - Bâtiment SN3 - 1er étage59655 Villeneuve d'Ascq Cedex France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.laboratoire-prism.fr/</ref>
          </desc>
          <listRelation>
            <relation name="U1192" active="#struct-303623" type="direct"/>
            <relation name="U1192" active="#struct-374570" type="direct"/>
            <relation name="U1192" active="#struct-425779" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-374570" status="VALID">
          <idno type="IdRef">223446556</idno>
          <idno type="ISNI">0000 0001 2242 6780</idno>
          <idno type="ROR">https://ror.org/02kzqn938</idno>
          <idno type="Wikidata">Q3551621</idno>
          <orgName>Université de Lille</orgName>
          <desc>
            <address>
              <addrLine>EPE Université de Lille. -- 42 rue Paul Duez, 59000 Lille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-425779" status="VALID">
          <idno type="IdRef">034424636</idno>
          <idno type="ISNI">0000000404718845</idno>
          <idno type="ROR">https://ror.org/02ppyfa04</idno>
          <idno type="Wikidata">Q2945741</idno>
          <orgName>Centre Hospitalier Régional Universitaire [CHU Lille]</orgName>
          <orgName type="acronym">CHRU Lille</orgName>
          <desc>
            <address>
              <addrLine>CHU/CHRU Lille - 2, avenue Oscar Lambret - 59037 Lille Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chru-lille.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>