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Journal Articles Trends in Cancer Year : 2018

The Evolving Landscape of Brain Metastasis

Abstract

Metastasis, involving the spread of systemic cancer to the brain, results in neurologic disability and death. Current treatments are largely palliative in nature; improved therapeutic approaches represent an unmet clinical need. However, recent experimental and clinical advances challenge the bleak long-term outcome of this disease. Encompassing key recent findings in epidemiology, genetics, microenvironment, leptomeningeal disease, neurocognition, targeted therapy, immunotherapy, and prophylaxis, we review preclinical and clinical studies to provide a comprehensive picture of contemporary research and the management of secondary brain tumors.

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inserm-02940674 , version 1 (16-09-2020)

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Manuel Valiente, Manmeet Ahluwalia, Adrienne Boire, Priscilla Brastianos, Sarah Goldberg, et al.. The Evolving Landscape of Brain Metastasis. Trends in Cancer, 2018, 4 (3), pp.176-196. ⟨10.1016/j.trecan.2018.01.003⟩. ⟨inserm-02940674⟩

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