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Journal Articles Trends in Cancer Year : 2018

The Evolving Landscape of Brain Metastasis


Metastasis, involving the spread of systemic cancer to the brain, results in neurologic disability and death. Current treatments are largely palliative in nature; improved therapeutic approaches represent an unmet clinical need. However, recent experimental and clinical advances challenge the bleak long-term outcome of this disease. Encompassing key recent findings in epidemiology, genetics, microenvironment, leptomeningeal disease, neurocognition, targeted therapy, immunotherapy, and prophylaxis, we review preclinical and clinical studies to provide a comprehensive picture of contemporary research and the management of secondary brain tumors.

Dates and versions

inserm-02940674 , version 1 (16-09-2020)



Manuel Valiente, Manmeet Ahluwalia, Adrienne Boire, Priscilla Brastianos, Sarah Goldberg, et al.. The Evolving Landscape of Brain Metastasis. Trends in Cancer, 2018, 4 (3), pp.176-196. ⟨10.1016/j.trecan.2018.01.003⟩. ⟨inserm-02940674⟩


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