%0 Journal Article %T Brain Substrates of Time-Based Prospective Memory Decline in Aging: A Voxel-Based Morphometry and Diffusion Tensor Imaging Study %T Neural substrates of prospective memory decline in aging %+ Neuropsychologie et imagerie de la mémoire humaine (NIMH) %+ GIP Cyceron (Cyceron) %A Morand, Alexandrine %A Segobin, Shailendra %A Lecouvey, Grégory %A Gonneaud, Julie %A Eustache, Francis %A Rauchs, Géraldine, Géraldine %A Desgranges, Béatrice %< avec comité de lecture %@ 1047-3211 %J Cerebral Cortex %I Oxford University Press (OUP) %8 2021 %D 2021 %R 10.1093/cercor/bhaa232 %K Aging %K Diffusion tensor imaging %K Episodic memory %K Prospective memory %K Voxel-based morphometry %Z Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]Journal articles %X Time-based prospective memory (TBPM) allows us to remember to perform intended actionsat a specific time in the future. TBPM is sensitive to the effects of age, but the neural substrates of thisdecline are still poorly understood. The aim of the present study was thus to better characterize thebrain substrates of the age-related decline in TBPM, focusing on macrostructural gray-matter andmicrostructural white-matter integrity. We administered a TBPM task to 22 healthy young (26 ± 5.2years) and 23 older (63 ± 5.9 years) participants, who also underwent volumetric magnetic resonanceimaging and diffusion tensor imaging scans. Neuroimaging analyses revealed lower gray-mattervolumes in several brain areas in older participants, but these did not correlate with TBPMperformance. By contrast, an age-related decline in fractional anisotropy in several white-matter tractsconnecting frontal and occipital regions did correlate with TBPM performance, while there was nosignificant correlation in healthy young subjects. According to the literature, these tracts are connectedto the anterior prefrontal cortex and the thalamus, two structures involved in TBPM. These resultsconfirm the view that a disconnection process occurs in aging and contributes to cognitive decline. %G English %2 https://inserm.hal.science/inserm-02933201/document %2 https://inserm.hal.science/inserm-02933201/file/Morand%20et%20al_CerCortex_2020_final.pdf %L inserm-02933201 %U https://inserm.hal.science/inserm-02933201 %~ INSERM %~ CEA %~ EPHE %~ CNRS %~ COMUE-NORMANDIE %~ PSL %~ UNICAEN %~ NIMH %~ TEST-DEV %~ EPHE-PSL