C. H. Phoenix, R. W. Goy, A. A. Gerall, and W. C. Young, Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig, Endocrinology, vol.65, pp.369-382, 1959.

J. A. Morris, C. L. Jordan, and S. M. Breedlove, Sexual differentiation of the vertebrate nervous system, Nature Neurosci, vol.7, pp.1034-1039, 2004.

P. Duarte-guterman, S. Yagi, C. Chow, and L. A. Galea, Hippocampal learning, memory, and neurogenesis: Effects of sex and estrogens across the lifespan in adults, Horm. Behav, vol.74, pp.37-52, 2015.

K. S. Ervin, Estrogen involvement in social behavior in rodents: Rapid and long-term actions, Horm. Behav, vol.74, pp.53-76, 2015.

A. Alexander, A. J. Irving, and J. Harvey, Emerging roles for the novel estrogen-sensing receptor GPER1 in the CNS, Neuropharmacology, vol.113, pp.652-660, 2017.

L. Naulé, Delayed pubertal onset and pre-pubertal Kiss1 expression in female mice lacking central estrogen receptor beta, Hum. Mol. Genet, vol.24, pp.7326-7338, 2015.

L. Naulé, Revisiting the neural role of estrogen receptor beta in male sexual behavior by conditional mutagenesis, Horm. Behav, vol.80, pp.1-9, 2016.

K. Raskin, Conditional inactivation of androgen receptor gene in the nervous system: effects on male behavioral and neuroendocrine responses, J. Neurosci, vol.29, pp.4461-4470, 2009.
URL : https://hal.archives-ouvertes.fr/hal-02527290

F. Tronche, Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety, Nat. Genet, vol.23, pp.99-103, 1999.

S. Ogawa, Survival of reproductive behaviors in estrogen receptor beta gene-deficient (betaERKO) male and female mice, Proc. Natl. Acad. Sci. USA, vol.96, pp.12887-12892, 1999.

M. Nomura, E. Mckenna, K. S. Korach, D. W. Pfaff, and S. Ogawa, Estrogen receptor-beta regulates transcript levels for oxytocin and arginine vasopressin in the hypothalamic paraventricular nucleus of male mice, Brain Res. Mol. Brain Res, vol.109, pp.525-534, 2002.

M. Nomura, Estrogen receptor-beta gene disruption potentiates estrogen-inducible aggression but not sexual behaviour in male mice, Eur. J. Neurosci, vol.23, pp.1860-1868, 2006.

M. Nakata, Effects of prepubertal or adult site-specific knockdown of estrogen receptor ? in the medial preoptic area and medial amygdala on social behaviors in male mice, vol.3, 2016.

M. Nakata, A. Ågmo, S. Sagoshi, and S. Ogawa, The role of estrogen receptor ? (ER?) in the establishment of hierarchical social relationships in male mice, Front. Behav. Neurosci, vol.12, 2018.

G. Sánchez-andrade and K. M. Kendrick, Roles of ?-and ?-estrogen receptors in mouse social recognition memory: effects of gender and the estrous cycle, Horm. Behav, vol.59, pp.114-122, 2011.

W. Krezel, S. Dupont, A. Krust, P. Chambon, and P. Chapman, Increased anxiety and synaptic plasticity in estrogen receptor beta -deficient mice, Proc. Natl. Acad. Sci. USA, vol.98, pp.12278-12282, 2001.

C. A. Frye, C. J. Koonce, K. L. Edinger, D. M. Osborne, and A. A. Walf, Androgens with activity at estrogen receptor beta have anxiolytic and cognitive-enhancing effects in male rats and mice, Horm. Behav, vol.54, pp.726-734, 2008.

A. E. Kudwa, R. F. Mcgivern, and R. J. Handa, Estrogen receptor ? and oxytocin interact to modulate anxiety-like behavior and neuroendocrine stress reactivity in adult male and female rats, Physiol. Behav, vol.129, pp.287-296, 2014.

D. M. Osborne, K. Edinger, and C. A. Frye, Chronic administration of androgens with actions at estrogen receptor beta have antianxiety and cognitive-enhancing effects in male rats, Age (Dordr), vol.31, pp.191-198, 2009.

T. D. Lund, T. Rovis, W. C. Chung, and R. J. Handa, Novel actions of estrogen receptor-beta on anxiety-related behaviors, Endocrinology, vol.146, pp.797-807, 2005.

M. G. Oyola, Anxiolytic effects and neuroanatomical targets of estrogen receptor-? (ER?) activation by a selective ER? agonist in female mice, Endocrinology, vol.153, pp.837-846, 2012.

A. A. Walf, C. J. Koonce, and C. A. Frye, Estradiol or diarylpropionitrile decrease anxiety-like behavior of wildtype, but not estrogen receptor beta knockout, mice, Behav. Neurosci, vol.122, pp.974-981, 2008.

, Scientific RepoRtS |, vol.10, p.6242, 2020.

M. J. Weiser, T. J. Wu, and R. J. Handa, Estrogen receptor-beta agonist diarylpropionitrile: biological activities of R-and S-enantiomers on behavior and hormonal response to stress, Endocrinology, vol.150, pp.1817-1825, 2009.

H. Suzuki, Involvement of estrogen receptor ? in maintenance of serotonergic neurons of the dorsal raphe, Mol. Psychiatry, vol.18, pp.674-680, 2013.

C. Marie-luce, Effects of neural androgen receptor disruption on aggressive behavior and arginine vasopressin system in the bed nucleus of stria terminalis, Gen. Comp. Endocrinol, vol.188, pp.218-225, 2013.

R. J. Handa, D. Sharma, and R. Uht, A role for the androgen metabolite, 5alpha androstane 3beta,17beta diol(3?-diol) in the regulation of the hypothalamo-pituitary-adrenal axis, Front. Endocrinol, 2011.

M. A. Lebow and A. Chen, Overshadowed by the amygdala: the bed nucleus of the stria terminalis emerges as key to psychiatric disorders, Mol. Psychiatry, vol.21, pp.450-63, 2016.

G. Murakami, R. G. Hunter, C. Fontaine, A. Ribeiro, and D. Pfaff, Relationships among estrogen receptor, oxytocin and vasopressin gene expression and social interaction in male mice, Eur. J. Neurosci, vol.34, pp.469-477, 2011.

S. Ogawa, D. B. Lubahn, K. S. Korach, and D. W. Pfaff, Behavioral effects of estrogen receptor gene disruption in male mice, Proc. Natl. Acad. Sci. USA, vol.94, pp.1476-1481, 1997.

K. Toda, T. Saibara, T. Okada, S. Onishi, and Y. Shizuta, A loss of aggressive behaviour and its reinstatement by oestrogen in mice lacking the aromatase gene (Cyp19), J. Endocrinol, vol.168, pp.217-220, 2001.

S. E. Daniel and D. G. Rainnie, Stress modulation of opposing circuits in the bed nucleus of the stria terminalis, Neuropsychopharmacology, vol.41, pp.103-125, 2016.

M. G. Oyola, M. K. Thompson, A. Z. Handa, and R. J. Handa, Distribution and chemical composition of estrogen receptor ? neurons in the paraventricular nucleus of the female and male mouse hypothalamus, J. Comp. Neurol, vol.525, pp.3666-3682, 2017.

P. J. Shughrue, T. L. Dellovade, and I. Merchenthaler, Estrogen modulates oxytocin gene expression in regions of the rat supraoptic and paraventricular nuclei that contain estrogen receptor-beta. Prog, Brain Res, vol.139, issue.02, pp.39004-39010, 2002.

S. X. Simonian and A. E. Herbison, Differential expression of estrogen receptor alpha and beta immunoreactivity by oxytocin neurons of rat paraventricular nucleus, J. Neuroendocrinol, vol.9, pp.803-806, 1997.

S. J. Somponpun and C. D. Sladek, Osmotic regulation of estrogen receptor-beta in rat vasopressin and oxytocin neurons, J. Neurosci, vol.23, pp.4261-4269, 2003.

S. J. Somponpun, M. C. Holmes, J. R. Seckl, and J. A. Russell, Modulation of oestrogen receptor-beta mRNA expression in rat paraventricular and supraoptic nucleus neurones following adrenal steroid manipulation and hyperosmotic stimulation, J. Neuroendocrinol, vol.16, pp.472-482, 2004.

N. Duque-wilckens, Inhibition of vasopressin V1a receptors in the medioventral bed nucleus of the stria terminalis has sexand context-specific anxiogenic effects, Neuropharmacology, vol.110, pp.59-68, 2016.

M. Moaddab and J. Dabrowska, Oxytocin receptor neurotransmission in the dorsolateral bed nucleus of the stria terminalis facilitates the acquisition of cued fear in the fear-potentiated startle paradigm in rats, Neuropharmacology, vol.121, pp.130-139, 2017.

N. Rigney, J. Whylings, M. Mieda, G. De-vries, and A. Petrulis, Sexually dimorphic vasopressin cells modulate social investigation and communication in sex-specific ways, vol.6, 2019.

J. Whylings, N. Rigney, N. V. Peters, G. J. De-vries, and A. Petrulis, Sexually dimorphic role of BNST vasopressin cells in sickness and social behavior in male and female mice, Brain Behav. Immun, vol.83, pp.68-77, 2020.

S. Hisasue, M. L. Seney, E. Immerman, and N. Forger, Control of cell number in the bed nucleus of the stria terminalis of mice: role of testosterone metabolites and estrogen receptor subtypes, J. Sex. Med, vol.7, pp.1401-1409, 2010.

C. Dombret, Loss of Maged1 results in obesity, deficits of social interactions, impaired sexual behavior and severe alteration of mature oxytocin production in the hypothalamus, Hum. Mol. Genet, vol.21, pp.4703-4717, 2012.
URL : https://hal.archives-ouvertes.fr/hal-01542831

G. Paxinos and K. B. Franklin, The Mouse Brain in Stereotaxic Coordinates, 2001.

R. St-louis, C. Parmentier, D. Raison, V. Grange-messent, and H. Hardin-pouzet, Reactive oxygen species are required for the hypothalamic osmoregulatory response, Endocrinology, vol.153, pp.1317-1329, 2012.
URL : https://hal.archives-ouvertes.fr/hal-01542829


, Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations