Adjunct immunotherapies for the management of severely ill COVID-19 patients - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Cell Reports Medicine Year : 2020

Adjunct immunotherapies for the management of severely ill COVID-19 patients

Abstract

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It has infected millions, with more than 275,000 fatal cases as of May 8, 2020. Currently, there are no specific COVID-19 therapies. Most patients depend on mechanical ventilation. Current COVID-19 data clearly highlight that cytokine storm and activated immune cell migration to the lungs characterize the early immune response to COVID-19 that causes severe lung damage and development of acute respiratory distress syndrome. In view of uncertainty associated with immunosuppressive treatments, such as corticosteroids and their possible secondary effects, including risks of secondary infections, we suggest immunotherapies as an adjunct therapy in severe COVID-19 cases. Such immunotherapies based on inflammatory cytokine neutralization, immunomodulation, and passive viral neutralization not only reduce inflammation, inflammation-associated lung damage, or viral load but could also prevent intensive care unit hospitalization and dependency on mechanical ventilation, both of which are limited resources.
Fichier principal
Vignette du fichier
cell_Rep_Med_2020.pdf (1.01 Mo) Télécharger le fichier
Origin : Publication funded by an institution
Loading...

Dates and versions

inserm-02555342 , version 1 (27-04-2020)
inserm-02555342 , version 2 (01-05-2020)
inserm-02555342 , version 3 (26-06-2020)

Licence

Attribution - NonCommercial - NoDerivatives

Identifiers

Cite

Srinivasa Reddy Bonam, Srini V Kaveri, Anavaj Sakuntabhai, Laurent Gilardin, Jagadeesh Bayry. Adjunct immunotherapies for the management of severely ill COVID-19 patients. Cell Reports Medicine, 2020, 1 (2), pp.100016. ⟨10.1016/j.xcrm.2020.100016⟩. ⟨inserm-02555342v3⟩
542 View
244 Download

Altmetric

Share

Gmail Facebook X LinkedIn More