Time-of-flight (TOF) implementation for PET reconstruction in practice - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Physics in Medicine and Biology Year : 2019

Time-of-flight (TOF) implementation for PET reconstruction in practice

Claude Comtat
Simon Stute


The time-of-flight (TOF) feature of PET scanners has been used for a long time in PET reconstruction, but many implementational aspects are still incomplete or ambiguous in the literature. Here we formalize and present theoretical and practical implementation details for the reconstruction of clinical TOF histogram and list-mode data using ML-EM. Relevant aspects include the computation of the TOF component of the system matrix, the processing of TOF bins, the use of estimations of random and scattered coincidences, and differences between histogram and list-mode ML-EM TOF reconstruction. Several approaches and approximations have been implemented in the CASToR platform and compared for OSEM reconstructions of patient data from the GE Signa PET/MR scanner. Differences between implementations are not larger than the typical bias in clinical data reconstruction. The largest difference and contrast loss occur when the processing of histogram TOF bins is simplified, and list-mode reconstruction is most sensitive to the truncation of the Gaussian TOF probability distribution.


Fichier principal
Vignette du fichier
Stute2020Eq13.pdf (806.29 Ko) Télécharger le fichier
Origin : Publication funded by an institution

Dates and versions

inserm-02484572 , version 1 (19-02-2020)



Marina Filipovic, Claude Comtat, Simon Stute. Time-of-flight (TOF) implementation for PET reconstruction in practice. Physics in Medicine and Biology, 2019, 64 (23), pp.23NT01. ⟨10.1088/1361-6560/ab4f0b⟩. ⟨inserm-02484572⟩
146 View
131 Download



Gmail Facebook X LinkedIn More