Regulation of intestinal homeostasis and tumorigenesis by the transcriptional coregulator RIP140
Résumé
Colon cancer frequently results from mutations that constitutively activate the Wnt signaling pathway, a major target being the tumor suppressor gene adenomatous polyposis coli (APC). We recently identified the transcription factor RIP140 as a new inducer of APC gene transcription that inhibits colon cancer cell growth and impedes the Wnt signaling pathway by reducing β-catenin activation.
Domaines
Sciences du Vivant [q-bio]
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Regulation of intestinal homeostasis and tumorigenesis by the transcriptional coregulator RIP140.pdf (1.66 Mo)
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