%0 Journal Article %T YAP-Mediated Mechanotransduction in Skeletal Muscle %+ Centre de recherche en myologie %+ Charité - UniversitätsMedizin = Charité - University Hospital [Berlin] %+ Freie Universität Berlin %A Fischer, Martina %A Rikeit, Paul %A Knaus, Petra %A Coirault, Catherine %< avec comité de lecture %@ 1664-042X %J Frontiers in Physiology %I Frontiers %V 7 %8 2016-02-16 %D 2016 %R 10.3389/fphys.2016.00041 %K YAP %K mechanotransduction %K skeletal muscle %K hippo pathway %K muscle homeostasis %Z Life Sciences [q-bio] %Z Life Sciences [q-bio]/Cellular Biology %Z Life Sciences [q-bio]/Biochemistry, Molecular Biology %Z Life Sciences [q-bio]/Development BiologyJournal articles %X Skeletal muscle is not only translating chemical energy into mechanical work, it is also a highly adaptive and regenerative tissue whose architecture and functionality is determined by its mechanical and physical environment. Processing intra-and extracellular mechanical signaling cues contributes to the regulation of cell growth, survival, migration and differentiation. Yes-associated Protein (YAP), a transcriptional coactivator downstream of the Hippo pathway and its paralog, the transcriptional co-activator with PDZ-binding motif (TAZ), were recently found to play a key role in mechanotransduction in various tissues including skeletal muscle. Furthermore, YAP/TAZ modulate myogenesis and muscle regeneration and abnormal YAP activity has been reported in muscular dystrophy and rhabdomyosarcoma. Here, we summarize the current knowledge of mechanosensing and-signaling in striated muscle. We highlight the role of YAP signaling and discuss the different routes and hypotheses of its regulation in the context of mechanotransduction. %G English %2 https://inserm.hal.science/inserm-02426450/document %2 https://inserm.hal.science/inserm-02426450/file/Fischer%20et%20al_YAP_Frontiers-2016.pdf %L inserm-02426450 %U https://inserm.hal.science/inserm-02426450 %~ INSERM %~ UPMC %~ CNRS %~ U974 %~ UPMC_POLE_4 %~ SORBONNE-UNIVERSITE %~ SU-MEDECINE %~ SU-TI %~ ALLIANCE-SU