<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of inserm-02341820</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-11T21:20:10+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Preliminary results of 68Ga-PSMA PET/CT prospective study in prostate cancer occult recurrence patients : diagnostic performance and impact on therapeutic decision-making</title>
            <author role="aut">
              <persName>
                <forename type="first">Caroline</forename>
                <surname>Rousseau</surname>
              </persName>
              <email type="md5">91b3a047049dcf6ca4e534f97fa33a1c</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="numeric">1041588</idno>
              <idno type="halauthorid" notation="string">586580-1041588</idno>
              <affiliation ref="#struct-499822"/>
              <affiliation ref="#struct-169555"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Maëlle</forename>
                <surname>Le Thiec</surname>
              </persName>
              <email type="md5">bb237ddf309e4554cc338a99e14d2ee8</email>
              <email type="domain">ico.unicancer.fr</email>
              <idno type="idhal" notation="numeric">1041997</idno>
              <idno type="halauthorid" notation="string">1430540-1041997</idno>
              <affiliation ref="#struct-169555"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ludovic</forename>
                <surname>Ferrer</surname>
              </persName>
              <email type="md5">9223f88fd9eedd4f08fedcb570ad9930</email>
              <email type="domain">ico.unicancer.fr</email>
              <idno type="idhal" notation="numeric">938700</idno>
              <idno type="halauthorid" notation="string">700528-938700</idno>
              <idno type="IDREF">https://www.idref.fr/158641728</idno>
              <affiliation ref="#struct-499822"/>
              <affiliation ref="#struct-457830"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">D.</forename>
                <surname>Rusu</surname>
              </persName>
              <idno type="halauthorid">850946-0</idno>
              <affiliation ref="#struct-169555"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">A.</forename>
                <surname>Rauscher</surname>
              </persName>
              <idno type="halauthorid">281802-0</idno>
              <affiliation ref="#struct-551507"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">B.</forename>
                <surname>Maucherat</surname>
              </persName>
              <idno type="halauthorid">1690862-0</idno>
              <affiliation ref="#struct-169555"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mathieu</forename>
                <surname>Frindel</surname>
              </persName>
              <idno type="halauthorid">1130418-0</idno>
              <affiliation ref="#struct-551507"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">P.</forename>
                <surname>Baumgartner</surname>
              </persName>
              <idno type="halauthorid">1691177-0</idno>
              <affiliation ref="#struct-551507"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">V.</forename>
                <surname>Fleury</surname>
              </persName>
              <email type="md5">df72aae63a4a13fef902e6d8420ef0d6</email>
              <email type="domain">gmail.com</email>
              <idno type="idhal" notation="numeric">1037034</idno>
              <idno type="halauthorid" notation="string">301181-1037034</idno>
              <idno type="IDREF">https://www.idref.fr/317200647</idno>
              <affiliation ref="#struct-169555"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">A.</forename>
                <surname>Denis</surname>
              </persName>
              <email type="md5">6a292776814556f281c22d8305997bd2</email>
              <email type="domain">chu-lyon.fr</email>
              <idno type="idhal" notation="string">angelique-denis</idno>
              <idno type="idhal" notation="numeric">745264</idno>
              <idno type="halauthorid" notation="string">53400-745264</idno>
              <affiliation ref="#struct-169555"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">N.</forename>
                <surname>Varmenot</surname>
              </persName>
              <idno type="halauthorid">870050-0</idno>
              <affiliation ref="#struct-457830"/>
              <affiliation ref="#struct-499822"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">E.</forename>
                <surname>Debeaupuis</surname>
              </persName>
              <idno type="halauthorid">1694202-0</idno>
              <affiliation ref="#struct-474972"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Loïc</forename>
                <surname>Campion</surname>
              </persName>
              <email type="md5">cc966b3a9b8153276062b24274f2ef45</email>
              <email type="domain">nantes.fnclcc.fr</email>
              <idno type="idhal" notation="numeric">761946</idno>
              <idno type="halauthorid" notation="string">428829-761946</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4903-0908</idno>
              <idno type="IDREF">https://www.idref.fr/169128628</idno>
              <affiliation ref="#struct-499820"/>
              <affiliation ref="#struct-544010"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Françoise</forename>
                <surname>Kraeber-Bodéré</surname>
              </persName>
              <email type="md5">9480af72d9b9633f9778af8a03cc9020</email>
              <email type="domain">chu-nantes.fr</email>
              <idno type="idhal" notation="numeric">1335905</idno>
              <idno type="halauthorid" notation="string">492844-1335905</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3417-0759</idno>
              <idno type="IDREF">https://www.idref.fr/073740314</idno>
              <affiliation ref="#struct-499822"/>
              <affiliation ref="#struct-169555"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Elizabeth</forename>
                <surname>Bernardo</surname>
              </persName>
              <email type="md5">373b15f895425e6af21c3cffa325a784</email>
              <email type="domain">univ-nantes.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2019-10-31 15:41:18</date>
              <date type="whenModified">2026-04-24 13:50:03</date>
              <date type="whenReleased">2019-11-04 14:00:54</date>
              <date type="whenProduced">2018</date>
              <date type="whenEndEmbargoed">2019-11-04</date>
              <ref type="file" target="https://inserm.hal.science/inserm-02341820v1/document">
                <date notBefore="2019-11-04"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://inserm.hal.science/inserm-02341820v1/file/OP-042%20EANM2018.pdf" id="file-2341820-2252766">
                <date notBefore="2019-11-04"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="326726">
                <persName>
                  <forename>Elizabeth</forename>
                  <surname>Bernardo</surname>
                </persName>
                <email type="md5">373b15f895425e6af21c3cffa325a784</email>
                <email type="domain">univ-nantes.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">inserm-02341820</idno>
            <idno type="halUri">https://inserm.hal.science/inserm-02341820</idno>
            <idno type="halBibtex">rousseau:inserm-02341820</idno>
            <idno type="halRefHtml">&lt;i&gt;European Journal of Nuclear Medicine and Molecular Imaging&lt;/i&gt;, 2018, 45 (1), pp.S21</idno>
            <idno type="halRef">European Journal of Nuclear Medicine and Molecular Imaging, 2018, 45 (1), pp.S21</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-2341820-2252766"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="UNIV-NANTES">Université de Nantes</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-ANGERS">Université d'Angers</idno>
            <idno type="stamp" n="CRCINA" corresp="INSERM">Centre de Recherche en Cancérologie et Immunologie Nantes Angers</idno>
            <idno type="stamp" n="CRCI2NA">Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers</idno>
            <idno type="stamp" n="NANTES-UNIVERSITE">Nantes Université</idno>
            <idno type="stamp" n="UNIV-NANTES-AV2022">Université de Nantes</idno>
            <idno type="stamp" n="TEST3-HALCNRS">TEST3-HALCNRS</idno>
            <idno type="stamp" n="UFR-MEDECINE-NANTES">UFR de médecine - Nantes Université</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Preliminary results of 68Ga-PSMA PET/CT prospective study in prostate cancer occult recurrence patients : diagnostic performance and impact on therapeutic decision-making</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Caroline</forename>
                    <surname>Rousseau</surname>
                  </persName>
                  <email type="md5">91b3a047049dcf6ca4e534f97fa33a1c</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="numeric">1041588</idno>
                  <idno type="halauthorid" notation="string">586580-1041588</idno>
                  <affiliation ref="#struct-499822"/>
                  <affiliation ref="#struct-169555"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Maëlle</forename>
                    <surname>Le Thiec</surname>
                  </persName>
                  <email type="md5">bb237ddf309e4554cc338a99e14d2ee8</email>
                  <email type="domain">ico.unicancer.fr</email>
                  <idno type="idhal" notation="numeric">1041997</idno>
                  <idno type="halauthorid" notation="string">1430540-1041997</idno>
                  <affiliation ref="#struct-169555"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ludovic</forename>
                    <surname>Ferrer</surname>
                  </persName>
                  <email type="md5">9223f88fd9eedd4f08fedcb570ad9930</email>
                  <email type="domain">ico.unicancer.fr</email>
                  <idno type="idhal" notation="numeric">938700</idno>
                  <idno type="halauthorid" notation="string">700528-938700</idno>
                  <idno type="IDREF">https://www.idref.fr/158641728</idno>
                  <affiliation ref="#struct-499822"/>
                  <affiliation ref="#struct-457830"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">D.</forename>
                    <surname>Rusu</surname>
                  </persName>
                  <idno type="halauthorid">850946-0</idno>
                  <affiliation ref="#struct-169555"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">A.</forename>
                    <surname>Rauscher</surname>
                  </persName>
                  <idno type="halauthorid">281802-0</idno>
                  <affiliation ref="#struct-551507"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">B.</forename>
                    <surname>Maucherat</surname>
                  </persName>
                  <idno type="halauthorid">1690862-0</idno>
                  <affiliation ref="#struct-169555"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mathieu</forename>
                    <surname>Frindel</surname>
                  </persName>
                  <idno type="halauthorid">1130418-0</idno>
                  <affiliation ref="#struct-551507"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">P.</forename>
                    <surname>Baumgartner</surname>
                  </persName>
                  <idno type="halauthorid">1691177-0</idno>
                  <affiliation ref="#struct-551507"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">V.</forename>
                    <surname>Fleury</surname>
                  </persName>
                  <email type="md5">df72aae63a4a13fef902e6d8420ef0d6</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="numeric">1037034</idno>
                  <idno type="halauthorid" notation="string">301181-1037034</idno>
                  <idno type="IDREF">https://www.idref.fr/317200647</idno>
                  <affiliation ref="#struct-169555"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">A.</forename>
                    <surname>Denis</surname>
                  </persName>
                  <email type="md5">6a292776814556f281c22d8305997bd2</email>
                  <email type="domain">chu-lyon.fr</email>
                  <idno type="idhal" notation="string">angelique-denis</idno>
                  <idno type="idhal" notation="numeric">745264</idno>
                  <idno type="halauthorid" notation="string">53400-745264</idno>
                  <affiliation ref="#struct-169555"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">N.</forename>
                    <surname>Varmenot</surname>
                  </persName>
                  <idno type="halauthorid">870050-0</idno>
                  <affiliation ref="#struct-457830"/>
                  <affiliation ref="#struct-499822"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">E.</forename>
                    <surname>Debeaupuis</surname>
                  </persName>
                  <idno type="halauthorid">1694202-0</idno>
                  <affiliation ref="#struct-474972"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Loïc</forename>
                    <surname>Campion</surname>
                  </persName>
                  <email type="md5">cc966b3a9b8153276062b24274f2ef45</email>
                  <email type="domain">nantes.fnclcc.fr</email>
                  <idno type="idhal" notation="numeric">761946</idno>
                  <idno type="halauthorid" notation="string">428829-761946</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4903-0908</idno>
                  <idno type="IDREF">https://www.idref.fr/169128628</idno>
                  <affiliation ref="#struct-499820"/>
                  <affiliation ref="#struct-544010"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Françoise</forename>
                    <surname>Kraeber-Bodéré</surname>
                  </persName>
                  <email type="md5">9480af72d9b9633f9778af8a03cc9020</email>
                  <email type="domain">chu-nantes.fr</email>
                  <idno type="idhal" notation="numeric">1335905</idno>
                  <idno type="halauthorid" notation="string">492844-1335905</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3417-0759</idno>
                  <idno type="IDREF">https://www.idref.fr/073740314</idno>
                  <affiliation ref="#struct-499822"/>
                  <affiliation ref="#struct-169555"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">22262</idno>
                <idno type="issn">1619-7070</idno>
                <idno type="eissn">1619-7089</idno>
                <title level="j">European Journal of Nuclear Medicine and Molecular Imaging</title>
                <imprint>
                  <publisher>Springer Verlag (Germany) [1976-....]</publisher>
                  <biblScope unit="volume">45</biblScope>
                  <biblScope unit="issue">1</biblScope>
                  <biblScope unit="pp">S21</biblScope>
                  <date type="datePub">2018</date>
                </imprint>
              </monogr>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv.can">Life Sciences [q-bio]/Cancer</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Introduction: The aim of this prospective study was to investigate the impact of 68Ga-PSMA-11 PET/CT on current management of prostate cancer patients with occult biochemical recurrence (BCR). Subjects &amp; Methods: 130 hormone-naïve occult BCR (PSA from 0.05 to 1.6 ng/mL) patients were enrolled in a prospective study (NCT03443609). All patients received a radical treatment (prostatectomy +/- radiotherapy) which allowed to an undetectable PSA level. Before PSMA PET/CT, patients were screened by conventional imaging as mpMRI and bone scan (+ trunk SPECT/ CT) and enrolled only if conventional imaging was doubtful or normal. PET images were recorded 1 and 2 hours after injection of 150 MBq of tracer and images interpreted by 2 nuclear physicians. Referring patient physician completed 2 questionnaires to assess PSMA PET imaging influence on therapeutic strategy: one prior and one after PSMA PET/CT indicating treatment plan without and with PSMA PET/CT information respectively. Six months after the end of treatment, a PSA assay was requested to evaluate therapeutic efficacy. Results: Currently, we have complete data analysis of the first 52 patients. After pre-screening, 7 patients were excluded due to positive MRI (5 pts) or bone scan (2 pts). The median time from radical prostatectomy or radiotherapy to BCR was 4.92y (0.6-15.46). Thirty-eight among the 52 patients (73%) had a positive PSMA PET/CT. Ninety-four lesions were detected, 53/94 in lymph nodes (56.4%) predominantly dispatched on pelvic area (75.5%), 25/94 in bone (26.6%) (mostly on axial skeleton) and 12/94 into prostate bed (12.7%). Detection rates were 56 %, 87 % and 74% for patients with PSA value ranging from 0.05 to 0.3, 0.3 to 0.6 and 0.6 to 1.6 ng/ml respectively. Thanks to PSMA PET/CT, therapeutic management changed in 35/52 patients (67.3%). PSMA-positive patients had undetectable PSA level after stereotaxic radiotherapy or focal surgery based on PSMA results in 30.7% (16/52). In this particular hormone naïve patient population, Rauscher’s nomogram (1) was not validate, may be due a too small population. Conclusion: Preliminary results of this prospective study showed, in more than half of patients, a major impact of PSMA PET/CT on treatment management allowing them to benefit very early from focal therapy with the great result for 30% of them of PSA complete response. Reference: (1) Rauscher I., et al: doi:10.1016/j.eururo.2018.01.006</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="researchteam" xml:id="struct-499822" status="OLD">
          <orgName>Nuclear Oncology</orgName>
          <orgName type="acronym">CRCINA-ÉQUIPE 13</orgName>
          <desc>
            <address>
              <addrLine>Institut de Recherche en Santé de l'Université de Nantes - 8 quai Moncousu - BP 70721 - 44007 Nantes cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.crcina.org/recherche/departement-3-nohmad/equipe-13-nuclear-oncology/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-477534" type="direct"/>
            <relation active="#struct-74911" type="indirect"/>
            <relation active="#struct-303623" type="indirect"/>
            <relation active="#struct-441569" type="indirect"/>
            <relation active="#struct-474972" type="indirect"/>
            <relation active="#struct-531638" type="indirect"/>
            <relation active="#struct-93263" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-169555" status="VALID">
          <orgName>Service de médecine nucléaire [Saint-Herblain]</orgName>
          <desc>
            <address>
              <addrLine>Boulevard Jacques Monod. 44805 Saint-Herblain</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.centregauducheau.fr/article.php3?id_article=18</ref>
          </desc>
          <listRelation>
            <relation active="#struct-342769" type="direct"/>
            <relation active="#struct-343015" type="direct"/>
            <relation active="#struct-444080" type="direct"/>
            <relation active="#struct-502406" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-457830" status="INCOMING">
          <orgName>Physique médicale [CRG-ICO, Saint-Herblain]</orgName>
          <desc>
            <address>
              <addrLine>Boulevard Professeur Jacques Monod, 44805 Saint-Herblain</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-444080" type="direct"/>
            <relation active="#struct-502406" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-551507" status="INCOMING">
          <orgName>Unité de Pharmacie [ICO, Saint Herblain]</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-444080" type="direct"/>
            <relation active="#struct-502406" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-474972" status="VALID">
          <idno type="IdRef">034926445</idno>
          <idno type="ROR">https://ror.org/05c1qsg97</idno>
          <idno type="Wikidata">Q2945767</idno>
          <orgName>Centre Hospitalier Universitaire de Nantes = Nantes University Hospital</orgName>
          <orgName type="acronym">CHU Nantes</orgName>
          <desc>
            <address>
              <addrLine>1 Place Alexis-Ricordeau, 44000 Nantes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-nantes.fr</ref>
          </desc>
        </org>
        <org type="researchteam" xml:id="struct-499820" status="OLD">
          <orgName>Integrative Oncogenomics of Multiple Myeloma Pathogenesis and Progression</orgName>
          <orgName type="acronym">CRCINA-ÉQUIPE 11</orgName>
          <desc>
            <address>
              <addrLine>CRCINA, INSERM UMR1232,CNRS ERL6001 - IRS-UN 8 Quai Moncousu - BP 70721 - 44007 Nantes Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.crcina.org/recherche/departement-3-nohmad/equipe-11-integrative-oncogenomics-of-multiple-myeloma-pathogenesis-and-progression/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-477534" type="direct"/>
            <relation active="#struct-74911" type="indirect"/>
            <relation active="#struct-303623" type="indirect"/>
            <relation active="#struct-441569" type="indirect"/>
            <relation active="#struct-474972" type="indirect"/>
            <relation active="#struct-531638" type="indirect"/>
            <relation active="#struct-93263" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-544010" status="INCOMING">
          <orgName>Unité de Biométrie [ICO, Saint Herblain]</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-444080" type="direct"/>
            <relation active="#struct-502406" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-477534" status="OLD">
          <idno type="IdRef">189169206</idno>
          <idno type="RNSR">200816529L</idno>
          <orgName>Centre de Recherche en Cancérologie et Immunologie Nantes-Angers</orgName>
          <orgName type="acronym">CRCINA</orgName>
          <date type="start">2017-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.crcina.org/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-74911" type="direct"/>
            <relation active="#struct-303623" type="direct"/>
            <relation active="#struct-441569" type="direct"/>
            <relation active="#struct-474972" type="direct"/>
            <relation active="#struct-531638" type="direct"/>
            <relation active="#struct-93263" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-74911" status="VALID">
          <idno type="IdRef">026402920</idno>
          <idno type="ISNI">0000000122483363</idno>
          <idno type="ROR">https://ror.org/04yrqp957</idno>
          <orgName>Université d'Angers</orgName>
          <orgName type="acronym">UA</orgName>
          <date type="start">1971-10-25</date>
          <desc>
            <address>
              <addrLine>Université d'Angers - 40 Rue de Rennes, BP 73532 - 49035 Angers CEDEX 01</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-angers.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-531638" status="OLD">
          <idno type="IdRef">076954927</idno>
          <orgName>Université de Nantes - UFR de Médecine et des Techniques Médicales</orgName>
          <orgName type="acronym">UFR MEDECINE</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>1 rue Gaston Veil BP 53508 44035 NANTES Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.medecine.univ-nantes.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-93263" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-93263" status="OLD">
          <idno type="IdRef">026403447</idno>
          <idno type="ROR">https://ror.org/03gnr7b55</idno>
          <orgName>Université de Nantes</orgName>
          <orgName type="acronym">UN</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>1, quai de Tourville - BP 13522 - 44035 Nantes cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-nantes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-342769" status="INCOMING">
          <orgName>Centre René Gauducheau</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-343015" status="INCOMING">
          <orgName>Institut Régional du Cancer Nantes-Atlantique (IRCNA)</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-444080" status="VALID">
          <idno type="ROR">https://ror.org/01m6as704</idno>
          <orgName>Institut de Cancérologie de l'Ouest [Angers/Nantes]</orgName>
          <orgName type="acronym">UNICANCER/ICO</orgName>
          <desc>
            <address>
              <addrLine>15, rue André Boquel - 49055 Angers cedex 02</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.institut-cancerologie-ouest.com/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-502406" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-502406" status="VALID">
          <orgName>UNICANCER</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75654 Paris Cedex 13</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.unicancer.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>