D. Ruzek, A. ?upanc, T. Borde, J. Chrdle, A. Eyer et al., Tick-borne encephalitis in Europe and Russia: review of pathogenesis, clinical features, therapy, and vaccines, Antiviral Res, vol.164, pp.23-51, 2019.

U. Dumpis, D. Crook, and J. Oksi, Tick-borne encephalitis, Clin Infect Dis, vol.28, pp.882-890, 1999.

F. X. Heinz and C. W. Mandl, The molecular-biology of tick-borne encephalitis virus, APMIS, vol.101, pp.735-745, 1993.

D. Ruzek, G. Dobler, and O. D. Mantke, Tick-borne encephalitis: pathogenesis and clinical implications, Travel Med Infect Dis, vol.8, pp.223-232, 2010.

L. Eyer, R. Nencka, E. De-clercq, K. Seley-radtke, and D. R??ek, Nucleoside analogs as a rich source of antiviral agents active against arthropodborne flaviviruses, Antivir Chem Chemother, vol.26, pp.1-28, 2018.

L. Eyer, M. ?mídková, R. Nencka, J. Ne?a, T. Kastl et al., Structure-activity relationships of nucleoside analogues for inhibition of tick-borne encephalitis virus, Antiviral Res, vol.133, pp.119-129, 2016.

L. Eyer, D. Zouharová, J. ?irmarová, M. Fojtíková, M. ?tefánik et al., Antiviral activity of the adenosine analogue BCX4430 against West Nile virus and tick-borne flaviviruses, 2017.

, Antiviral Res, vol.142, pp.63-67

L. Eyer, H. Kondo, D. Zouharova, M. Hirano, J. J. Valdes et al., Escape of tick-borne flavivirus from 2=-C-methylated nucleoside antivirals is mediated by a single conservative mutation in NS5 That has a dramatic effect on viral fitness, J Virol, vol.91, pp.1-20, 2017.

L. Eyer, J. J. Valdés, V. A. Gil, R. Nencka, H. H?ebabecký et al., Nucleoside inhibitors of tickborne encephalitis virus, Antimicrob Agents Chemother, vol.59, pp.5483-5493, 2015.

T. K. Warren, J. Wells, R. G. Panchal, K. S. Stuthman, N. L. Garza et al., Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430, Nature, vol.508, pp.402-405, 2014.

D. Clercq and E. , C-nucleosides to be revisited, J Med Chem, vol.59, pp.2301-2311, 2016.

J. G. Julander, V. Siddharthan, J. Evans, R. Taylor, K. Tolbert et al., Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model, Antiviral Res, vol.137, pp.14-22, 2017.

J. G. Julander, S. Bantia, B. R. Taubenheim, D. M. Minning, P. Kotian et al., BCX4430, a novel nucleoside analog, effectively treats Yellow Fever in a hamster model, Antimicrob Agents Chemother, vol.58, pp.6607-6614, 2014.

R. Taylor, P. Kotian, T. Warren, R. Panchal, S. Bavari et al., BCX4430: a broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease, J Infect Public Health, vol.9, pp.220-226, 2016.

J. B. Westover, A. Mathis, R. Taylor, L. Wandersee, K. W. Bailey et al., Galidesivir limits Rift Valley fever virus infection and disease in Syrian golden hamsters, 2018.

, Antiviral Res, vol.156, pp.38-45

S. Bagaglio, C. Uberti-foppa, and G. Morsica, Resistance mechanisms in hepatitis C virus: implications for direct-acting antiviral use, Drugs, vol.77, pp.1043-1055, 2017.

K. K. Irwin, N. Renzette, T. F. Kowalik, and J. D. Jensen, Antiviral drug resistance as an adaptive process, Virus Evol, vol.2, pp.1-10, 2016.

E. Poveda, D. L. Wyles, A. Mena, J. D. Pedreira, A. Castro-iglesias et al., Update on hepatitis C virus resistance to direct-acting antiviral agents, 2014.

, Antiviral Res, vol.108, pp.181-191

A. S. Lauring, J. Frydman, and R. Andino, The role of mutational robustness in RNA virus evolution, Nat Rev Microbiol, vol.11, pp.327-336, 2013.

L. Eyer, A. Nougairède, M. Uhlí?ová, J. Driouich, D. Zouharová et al., An E460D substitution in the NS5 protein of tick-borne encephalitis virus confers resistance to the inhibitor galidesivir (BCX4430) and also attenuates the virus for mice, 2019.
URL : https://hal.archives-ouvertes.fr/inserm-02315654

F. Aubry, A. Nougairede, L. De-fabritus, G. Querat, E. A. Gould et al., Single-stranded positive-sense RNA viruses generated in days using infectious subgenomic amplicons, J Gen Virol, vol.95, pp.2462-2467, 2014.

J. Driouich, S. M. Ali, A. Amroun, A. F. De-lamballerie, X. Nougairède et al., SuPReMe: a rapid reverse genetics method to generate clonal populations of recombinant RNA viruses, Emerg Microbes Infect, vol.7, pp.1-11, 2018.

J. M. Pawlotsky, Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus, Hepatology, vol.53, pp.1742-1751, 2011.

E. De-clercq and J. Neyts, Antiviral agents acting as DNA or RNA chain terminators, Handb Exp Pharmacol, vol.189, pp.53-84, 2009.

K. Hercik, J. Brynda, R. Nencka, and E. Boura, Structural basis of Zika virus methyltransferase inhibition by sinefungin, Arch Virol, vol.162, pp.2091-2096, 2017.

K. Hercik, J. Kozak, M. Sala, M. Dejmek, H. Hrebabecky et al., Adenosine triphosphate analogs can efficiently inhibit the Zika virus RNA-dependent RNA polymerase, Antiviral Res, vol.137, pp.131-133, 2017.

G. Migliaccio, J. E. Tomassini, S. S. Carroll, L. Tomei, S. Altamura et al., Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro, J Biol Chem, vol.278, pp.49164-49170, 2003.

H. T. Xu, S. A. Hassounah, S. P. Colby-germinario, M. Oliveira, C. Fogarty et al., Purification of Zika virus RNA-dependent RNA polymerase and its use to identify small-molecule Zika inhibitors, J Antimicrob Chemother, vol.72, pp.727-734, 2017.

M. Flint, L. K. Mcmullan, K. A. Dodd, B. H. Bird, M. L. Khristova et al., Inhibitors of the tick-borne, hemorrhagic feverassociated flaviviruses, Antimicrob Agents Chemother, vol.58, pp.3206-3216, 2014.

L. Delang, P. S. Yen, T. Vallet, M. Vazeille, M. Vignuzzi et al., Differential transmission of antiviral drug-resistant chikungunya viruses by Aedes mosquitoes, vol.3, pp.230-248, 2018.
URL : https://hal.archives-ouvertes.fr/pasteur-01865525

A. Khatun, N. Shabir, B. J. Seo, B. S. Kim, K. J. Yoon et al., The attenuation phenotype of a ribavirin-resistant porcine reproductive and respiratory syndrome virus is maintained during sequential passages in pigs, J Virol, vol.90, pp.4454-4468, 2016.

D. B. Gammon, R. Snoeck, P. Fiten, M. Krecmerova, A. Holy et al., Mechanism of antiviral drug resistance of vaccinia virus: identification of residues in the viral DNA polymerase conferring differential resistance to antipoxvirus drugs, J Virol, vol.82, pp.12520-12534, 2008.

J. M. Groarke and D. C. Pevear, Attenuated virulence of pleconaril-resistant coxsackievirus B3 variants, J Infect Dis, vol.179, pp.1538-1541, 1999.

L. Pospisil, L. Jandasek, and J. Pesek, Isolation of new strains of meningoencephalitis virus in the Brno region during the summer of 1953, Lek List, vol.9, pp.3-5, 1954.

O. Kozuch and V. Mayer, Pig kidney epithelial (Ps) cells: perfect tool for study of flaviviruses and some other arboviruses, Acta Virol, vol.19, p.498, 1975.

D. Ruzek, T. S. Gritsun, N. L. Forrester, E. A. Gould, J. Kopecky et al., Mutations in the NS2B and NS3 genes affect mouse neuroinvasiveness of a Western European field strain of tick-borne encephalitis virus, Virology, vol.374, pp.249-255, 2008.

F. Aubry, A. Nougairede, L. De-fabritus, G. Piorkowski, E. A. Gould et al., ISA-Lation of single-stranded positive-sense RNA viruses from non-infectious clinical/animal samples, PLoS One, vol.10, pp.1-10, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01236720

D. Madrid, A. T. Porterfield, and J. S. , A simple micro-culture method for the study of group B arboviruses, Bull World Health Organ, vol.40, pp.113-121, 1969.