Viral and tumor antigen-specific CD8 T-cell responses in Merkel cell carcinoma - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Cellular Immunology Year : 2019

Viral and tumor antigen-specific CD8 T-cell responses in Merkel cell carcinoma

Abstract

Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous cancer, which is immunogenic, regardless of the presence of MCPyV (80% of cases). The identification of MCC-specific epitopes recognized by CD8 T cells is crucial to expand the arsenal of immunotherapeutic treatments. Until now, most efforts focused on the identification of virus-specific epitopes, whereas immune responses directed against shared cellular tumor-specific antigens have not been evidenced. In this study, we measured T-cell responses against viral (n = 3) and tumor antigens (n = 47) from TILs derived from 21 MCC tumors. Virus-specific CD8 T-cell responses dominated MCC-specific immune responses, and we identified two new HLA-peptide complexes derived from the LT antigen, located in a region encompassing 3 previously identified epitopes. Finally, we show that MAGE-A3 antigen, frequently expressed by MCC tumors, was recognized by CD8 TILs from a virus-negative MCC tumor and thus could be a target for immunotherapy in this setting.
Embargoed file
Embargoed file
Visibility date is undetermined
Loading...

Dates and versions

inserm-02284748 , version 1 (12-09-2019)

Identifiers

Cite

Mahtab Samimi, Houssem Benlalam, Pascal Aumond, Pauline Gaboriaud, Delphine Fradin, et al.. Viral and tumor antigen-specific CD8 T-cell responses in Merkel cell carcinoma. Cellular Immunology, 2019, 344, 8 p. ⟨10.1016/j.cellimm.2019.103961⟩. ⟨inserm-02284748⟩
89 View
3 Download

Altmetric

Share

Gmail Facebook X LinkedIn More