Article Dans Une Revue PLoS Pathogens Année : 2019

Sensing of cell-associated HTLV by plasmacytoid dendritic cells is regulated by dense β-galactoside glycosylation

Résumé

Human T Lymphotropic virus (HTLV) infection can persist in individuals resulting, at least in part, from viral escape of the innate immunity, including inhibition of type I interferon response in infected T-cells. Plasmacytoid dendritic cells (pDCs) are known to bypass viral escape by their robust type I interferon production. Here, we demonstrated that pDCs produce type I interferons upon physical cell contact with HTLV-infected cells, yet pDC activation inversely correlates with the ability of the HTLV-producing cells to transmit infection. We show that pDCs sense surface associated-HTLV present with glycan-rich structure referred to as biofilm-like structure, which thus represents a newly described viral structure triggering the antiviral response by pDCs. Consistently, heparan sulfate proteoglycans and especially the cell surface pattern of terminal β-galactoside glycosylation, modulate the transmission of the immunostimulatory RNA to pDCs. Altogether, our results uncover a function of virus-containing cell surface-associated glycosylated structures in the activation of innate immunity.
Fichier principal
Vignette du fichier
journal.ppat.1007589.pdf (2.48 Mo) Télécharger le fichier
Origine Publication financée par une institution
Loading...

Dates et versions

inserm-02166085 , version 1 (26-06-2019)

Identifiants

Citer

Sonia Assil, Nicolas Futsch, Elodie Décembre, Sandrine Alais, Antoine Gessain, et al.. Sensing of cell-associated HTLV by plasmacytoid dendritic cells is regulated by dense β-galactoside glycosylation. PLoS Pathogens, 2019, 15 (2), pp.e1007589. ⟨10.1371/journal.ppat.1007589⟩. ⟨inserm-02166085⟩
77 Consultations
193 Téléchargements

Altmetric

Partager

More