The Free Fatty Acid Receptor G Protein-coupled Receptor 40 (GPR40) Protects from Bone Loss through Inhibition of Osteoclast Differentiation
Résumé
Background: Long chain fatty acids have been shown to activate the membrane-bound receptor GPR40.
Results: GPR40 agonist alters bone-resorbing cell differentiation through inhibition of the NF-B system.
Conclusion: GPR40 exerts protective effects in vivo on bone tissue.
Significance: GPR40 is a nutritional and therapeutic target opening up new avenues for clinical investigations in terms of metabolic and age-related bone disorders.
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