%0 Journal Article %T Segmentierte Fadenförmige Bakterien, Th17 Induktoren und Helfer in einer feindlichen Welt %T Segmented filamentous bacteria, Th17 inducers and helpers in a hostile world %T Les bactéries filamenteuses segmentées, des inducteurs Th17 et des aides dans un monde hostile %+ Imagine - Institut des maladies génétiques (IMAGINE - U1163) %+ MICrobiologie de l'ALImentation au Service de la Santé (MICALIS) %+ Pathogénie Microbienne Moléculaire %+ Collège de France - Chaire Microbiologie et Maladies infectieuses %+ Interactions de l'épithelium intestinal et du système immunitaire (UMR_S 793) %A Schnupf, Pamela %A Gaboriau-Routhiau, Valerie, V. %A Sansonetti, Philippe %A Cerf-Bensussan, Nadine %Z INSERM ; Universite Paris Descartes ; INRA ; Institut Pasteur ; programmes 'Investissement d'Avenir' ANR-10-IAHU-01 ANR-10-LABX-62-01 ; BMGF Grand Challenge grant OPP1141338 ERC-2013-AdG 339407-IMMUNOBIOTA ERC-2014-AdGDECRYPT %< avec comité de lecture %@ 1369-5274 %J Current Opinion in Microbiology %I Elsevier %V 35 %N 35 %P 100-109 %8 2017-04-27 %D 2017 %R 10.1016/j.mib.2017.03.004 %M 28453971 %Z Life Sciences [q-bio] %Z Life Sciences [q-bio]/Human health and pathologyJournal articles %X The Th17 cell composition in the murine gut is strikingly dependent on the presence of the commensal segmented filamentous bacteria (SFB). SFB potently stimulates innate and adaptive immune responses and protects the host from pathogens both in and outside of the gut, partly due to its unique ability to promote a Th17-fostering environment. Recent work has highlighted the role of the tight adherence of SFB to the intestinal surface in mediating the potent immunostimulatory potential of SFB. Progress has also been made in our understanding of how SFB fosters this protective immune environment on the cellular and molecular level. This review focuses on the ability of SFB to specifically stimulate Th17 immunity. %G English %L inserm-01516893 %U https://inserm.hal.science/inserm-01516893 %~ INSERM %~ PASTEUR %~ UNIV-PARIS5 %~ AGROPARISTECH %~ CDF %~ INRA %~ OPENAIRE %~ PSL %~ USPC %~ UNIV-PARIS-SACLAY %~ AGREENIUM %~ AGROPARISTECH-SACLAY %~ INRA-SACLAY %~ INRAE %~ UNIV-PARIS %~ UP-SANTE %~ CDF-PSL %~ ANR %~ GS-BIOSPHERA %~ GS-HEALTH-DRUG-SCIENCES %~ MICALIS