%0 Journal Article %T Fat-soluble vitamin intestinal absorption: Absorption sites in the intestine and interactions for absorption %+ Nutrition, obésité et risque thrombotique (NORT) %+ Lesieur %A Goncalves, Aurélie %A Roi, Stéphanie %A Nowicki, Marion %A Dhaussy, Amélie %A Huertas, Alain %A Amiot, Marie-Josèphe %A Reboul, Emmanuelle %Z CIFRE grants from the ANRT [French national association for research and technology] ; Lesieur company %< avec comité de lecture %@ 0308-8146 %J Food Chemistry %I Elsevier %V 172 %P 155 - 160 %8 2015 %D 2015 %R 10.1016/j.foodchem.2014.09.021 %K Retinol %K Cholecalciferol %K Tocopherol %K Phylloquinone %K Digestion %K rat %K mechanism %K carotenoid %K alpha-tocopherol %K Enterocyte %K I SR-BI %K diet %K transport %K cell %Z Life Sciences [q-bio]/Food and NutritionJournal articles %X The interactions occurring at the intestinal level between the fat-soluble vitamins A, D, E and K (FSVs) are poorly documented. We first determined each FSV absorption profile along the duodenal-colonic axis of mouse intestine to clarify their respective absorption sites. We then investigated the interactions between FSVs during their uptake by Caco-2 cells. Our data show that vitamin A was mostly absorbed in the mouse proximal intestine, while vitamin D was absorbed in the median intestine, and vitamin E and K in the distal intestine. Significant competitive interactions for uptake were then elucidated among vitamin D, E and K, supporting the hypothesis of common absorption pathways. Vitamin A also significantly decreased the uptake of the other FSVs but, conversely, its uptake was not impaired by vitamins D and K and even promoted by vitamin E. These results should be taken into account, especially for supplement formulation, to optimise FSV absorption. %G English %L inserm-01478577 %U https://inserm.hal.science/inserm-01478577 %~ INSERM %~ UNIV-AMU %~ INRA %~ AGREENIUM %~ INRAE